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    Phcog.Net JOURNAL OF PHARMACOLOGY AND PHARMACOTHERAPEUTICS Volume 4 · Issue 4 2013 · pp. 227–308
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    Cover: Journal of Pharmacology and Pharmacotherapeutics

    Journal of Pharmacology and Pharmacotherapeutics

    Volume 4, Issue 4

    2013 · pp. 227–308 · 18 articles

    Volume
    4
    Issue
    4
    Published
    2013
    Pages
    227–308
    Articles
    18
    Sections
    7
    ISSN
    ISSN: Print - 0976-500X, Online - 0976-5018
    Journal
    J Pharmacol. Pharmacother.
    EditorialMini ReviewResearch PaperResearch LetterCase ReportEducational ForumWebwise

    In this issue

    Editorial

    1. Forum Article

      Pioglitazone suspension and its aftermath: A wake up call for the Indian drug regulatory authorities

      Arif Hashmi

      pp. 227–229 · DOI: 10.4103/0976-500X.119705 · Published 2013

      Pioglitazone, the commonly used antidiabetic drug was placed under suspension in June (June 18, 2013). The suspension was promulgated in the Government gazette.[1] It was not recommended by the Drug Technical Advisory Bo…

    Mini Review

    1. Article

      Cabazitaxel: A novel taxane for metastatic castration‑resistant prostate cancer‑current implications and future prospects

      Afroz Abidi

      pp. 230–237 · DOI: 10.4103/0976-500X.119704 · Published 2013

      Recent advances in the management of prostate cancer have shown considerable development with time and many novel therapeutic agents have been approved over the past years. For patients with metastatic castration‑resista…

    Research Paper

    1. Article

      Anti-inflammatory activity of calcium channel blocker lercanidipine hydrochloride

      Prathap Vasigar, Mounissamy Batmanabane

      pp. 238–242 · DOI: 10.4103/0976-500X.119707 · Published 2013

      Objective: To evaluate the anti-inflammatory effect of the third-generation CCB, lercanidipine. Materials and Methods: The ability of lercanidipine to reduce inflammation in carrageenan‑induced paw edema in rats was eval…

    2. Article

      Three‑way, three‑period, crossover bioequivalence study of single oral dose of three brands of 300 mg phenytoin sodium tablets marketed in India, on healthy Indian human volunteers

      Maulik S. Doshi, Anuja A. Naik, Mohit R. Mehta, Nithya J. Gogtay, Urmila M. Thatte, Mala D. Menon

      pp. 243–246 · DOI: 10.4103/0976-500X.119709 · Published 2013

      Objective: To compare the bioavailability of two brands of phenytoin sodium tablets available in the Indian market using EptoinTM as the reference. Materials and Methods: A randomized, assessor‑blind, three‑way crossover…

    3. Article

      Evaluation of a new computerized psychometric test battery: Effects of zolpidem and caffeine

      Raveendranadh Pilli, MUR Naidu, Usharani Pingali, JC Shobha

      pp. 247–248 · DOI: 10.4103/0976-500X.119710 · Published 2013

      Objective: To evaluate the effects of centrally active drugs using a new indigenously developed automated psychometric test system and compare the results with that obtained using pencil- and paper-based techniques. Mate…

    4. Article

      Virtual screening studies reveal linarin as a potential natural inhibitor targeting CDK4 in retinoblastoma

      Muthukumaran Sivashanmugam, Chandana Raghunath, Umashankar Vetrivel

      pp. 256–264 · DOI: 10.4103/0976-500X.119711 · Published 2013

      Objective: To find out whether linarin can be used as a potential natural inhibitor to target CDK4 in retinoblastoma using virtual screening studies. Materials and Methods: In this study, molecular modeling and protein s…

    5. Article

      Expression of cFos and brain‑derived neurotrophic factor in cortex and hippocampus of ethanol‑withdrawn male and female rats

      Paul E. Alele, Leslie L. Devaud

      pp. 265–274 · DOI: 10.4103/0976-500X.119712 · Published 2013

      Objective: To map areas of brain activation (cFos) alongside changes in levels of brain-derived neurotrophic factor (BDNF) to provide insights into neuronal mechanisms contributing to previously observed sex differences …

    6. Article

      Apoptosis amelioration through hypothermic reperfusion in heart transplant

      Fadhil G. Al‑Amran

      pp. 275–280 · DOI: 10.4103/0976-500X.119713 · Published 2013

      Objective: To investigate the effects of two different sets of graft temperature during perfusion on myocardial protection in the immediate post transplantation period in rats. Materials and Methods: Rats grouped into: S…

    Research Letter

    1. Article

      Inadequate pain relief for patients with trauma: A cause for concern?

      Sadasivam Balakrishnan, Ratinder Jhaj, Vishnu Raj

      pp. 281–281 · DOI: 10.4103/0976-500X.119714 · Published 2013

      Pain relief is the major reason why patients come to a hospital.[1] Trauma is a chief cause of pain and suffering.[2] Road traffic accidents (RTA) are on the increase due to a variety of factors. Crush injuries and fract…

    2. Article

      Modulation of conditioned avoidance response and quetiapine‑induced metabolic syndrome by rosuvastatin and CDP‑choline in rats

      Ahmad Shafique, K. K. Pillai, Abdi Sayed Aliul Hasan, A. K. Najmi

      pp. 283–285 · DOI: 10.4103/0976-500X.119716 · Published 2013

      The rats (Wistar rat) were divided into nine groups, each group containing eight rats. In this study, psychotic symptoms were induced in rats through Conditioned Avoidance Response (CAR) using Cook’s pole climbing appara…

    3. Article

      Cardiovascular medications among the critically ill patients of a tertiary care hospital: A drug utilization study

      Lisha Jenny John, Padmini Devi, Shoba Guido

      pp. 285–287 · DOI: 10.4103/0976-500X.119717 · Published 2013

      Cardiovascular disorders are one of the leading causes of mortality and morbidity. The patients admitted to the medical intensive care unit (MICU) represent a diverse patient population with variable demographic characte…

    Case Report

    1. Article

      Paroxetine in the treatment of recurrent brief depressive disorder

      Sathya Prakash, Piyali Mandal, Rajesh Sagar

      pp. 288–290 · DOI: 10.4103/0976-500X.119718 · Published 2013

      Recurrent brief depressive disorder is now a well‑recognized type of depressive disorder. However, there is still no clear evidence base for its treatment. The efficacy of several drugs including antidepressants and mood…

    2. Article

      Phenytoin induced Stevens-Johnson syndrome exacerbated by cefepime

      Varsha A. Prabhu, Sahiti Doddapaneni, Girish Thunga, Rajakannan Thiyagu, M. Mukyaprana Prabhu, Kushal Naha

      pp. 291–293 · DOI: 10.4103/0976-500X.119719 · Published 2013

      Steven Johnson syndrome (SJS) is a rare drug induced mucocutaneous reaction. Here, we present an elaborate report of a 28‑year‑old female patient who developed Phenytoin induced SJS, which was exacerbated by cefepime.

    3. Article

      Elevation of blood ciclosporin levels by voriconazole leading to leukoencephalopathy

      Qu Caihong, Liu Weimin, Zhu Jieming

      pp. 294–297 · DOI: 10.4103/0976-500X.119721 · Published 2013

      We report that one 18‑year‑old female patient with no epilepsia history developed severe epileptiform seizures while she was receiving “ciclosporin A (CsA)-mycophenolate-methylprednisolone” antirejection therapy after co…

    4. Article

      Idiopathic intracranial hypertension secondary to ingestion of Morinda coreia and Azadirachta indica leaves extract in infant

      Thirunavukkarasu Arun Babu, Shanthi Ananthakrishnan

      pp. 298–299 · DOI: 10.4103/0976-500X.119722 · Published 2013

      We report a case of idiopathic intracranial hypertension (IIH) secondary to ingestion of Morinda coreia (Nonan) and Azadirachta indica (Neem) leaves extract in a nine months old child. This herbal extract is believed to …

    5. Article

      A rare case of ethambutol induced pulmonary eosinophilia

      Kaushik Saha, Ankan Bandyopadhyay, Amitabha Sengupta, Debraj Jash

      pp. 300–302 · DOI: 10.4103/0976-500X.119724 · Published 2013

      Antitubercular drug (ATD) induced eosinophilic lung disease is a rare phenomenon. It usually occurs due to isoniazid and para amino salicylic acid. A 34-year-male of sputum positive pulmonary tuberculosis, on antitubercu…

    Educational Forum

    1. Article

      How to calculate sample size in animal studies?

      Jaykaran Charan, N. D. Kantharia

      pp. 303–304 · DOI: 10.4103/0976-500X.119726 · Published 2013

      Calculation of sample size is one of the important component of design of any research including animal studies. If a researcher select less number of animals it may lead to missing of any significant difference even if …

    Webwise

    1. Article

      The pharmacovigilance toolkit

      P. Ravi Shankar

      pp. 307–308 · DOI: · Published 2013

      Pharmacovigilance (PV), a key intervention for promoting the safe and rational use of medicines is especially important in developing countries where there is often no legal requirement for medicines to be tested in indi…