Volume 7, Issue 4

Review Article

1. Review

   Lesinurad: A significant advancement or just another addition to existing therapies of gout?

   Ajay Gupta, Pramod Kumar Sharma, Arup Kumar Misra, Surjit Singh

   pp. 155–158 · DOI: 10.4103/0976-500X.195897 · Published 2016

   Gout is a metabolic disorder that usually presents as recurrent episodes of acute arthritis due to deposition of crystals in joints and cartilages. Despite the availability of several drugs for gout, its management is st…

Research Paper

1. Article

   Hypertension influences the exponential progression of inflammation and oxidative stress in streptozotocin‑induced diabetic kidney

   Rupadevi Muthaian, Rajaa Muthu Pakirisamy, Subramani Parasuraman, Ramasamy Raveendran

   pp. 159–164 · DOI: 10.4103/0976-500X.195898 · Published 2016

   Objective: To investigate the association of hypertension coexisting with diabetes mellitus with oxidative stress and inflammation in the kidneys of streptozotocin (STZ)‑induced diabetic rats. Materials and Methods: Male…

2. Article

   QTc interval in young Gujarati hypertensives: Effect of disease, antihypertensive monotherapy, and coexisting risk factors

   Jayesh Dalpatbhai Solanki, Bhakti P. Gadhavi, Amit H. Makwana, Hemant B. Mehta, Chinmay J. Shah

   pp. 165–170 · DOI: 10.4103/0976-500X.195900 · Published 2016

   Objectives: To study the effect of disease duration, treatment and risk factors on QTc interval among young hypertensives. Materials and Methods: A case–control study was conducted on 142 hypertensives (60 males, 82 fema…

3. Article

   Comparison of efficacy, safety, and cost‑effectiveness of rupatadine and olopatadine in patients of allergic rhinitis: A prospective, randomized, double‑blind, parallel group study

   Ganesh Dakhale, Yogesh Tathod, Seema Patel, Sonali Pimpalkhute, Latesh Raghute, Ajita Khamkar

   pp. 171–176 · DOI: 10.4103/0976-500X.195901 · Published 2016

   Objective: To compare the efficacy, safety, and cost‑effectiveness of rupatadine and olopatadine in patients of allergic rhinitis (AR). Materials and Methods: A 2‑week, single‑centered, randomized, double‑blind, parallel…

4. Article

   Inhibition by tadalafil of contractility of isolated nonpregnant human myometrium

   Sumalya Sen, Anitha Thomas, Saibal Das, Jayanta Kumar Dey, Abraham Peedicayil, Vinotha Thomas

   pp. 177–181 · DOI: 10.4103/0976-500X.195902 · Published 2016

   Objective: To investigate the inhibitory effect of tadalafil on the contractility of isolated nonpregnant human myometrium. Materials and Methods: The ability of tadalafil (25, 40, and 63 µM) to inhibit 55 mM KCl‑induced…

Case Report

1. Article

   Clozapine‑induced cataract in a young female

   Md. Shahid Alam, K. V. Praveen Kumar

   pp. 184–186 · DOI: 10.4103/0976-500X.195904 · Published 2016

   A variety of systemic drugs including corticosteroids, amiodarone and antipsychotics have been known to cause cataract formation. Typical antipsychotics such as chlorpromazine have been reported to cause cataract formati…

2. Article

   Presumed isotretinoin-induced extraocular myopathy

   Md. Shahid Alam, Swati Agarwal

   pp. 187–9 · DOI: 10.4103/0976-500X.195905 · Published 2016

   Isotretinoin a synthetic analogue of vitamin A is primarily used for cystic acne not responding to conventional treatment. Several ocular side effects including blurring of vision, decreased dark adaptation, corneal opac…

Molecules of Millennium

1. Article

   Proprotein convertase subtilisin/kexin type 9 enzyme inhibitors: An emerging new therapeutic option for the treatment of dyslipidemia

   Faizan Mazhar, Nafis Haider

   pp. 190–3 · DOI: 10.4103/0976-500X.195906 · Published 2016

   The treatment of hypercholesterolemia entered in a new phase of development with the introduction of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in the market. The Food and Drug Administration and Eu…

1. Article

   Lifitegrast: A novel drug for treatment of dry eye disease

   Afroz Abidi, Pooja Shukla, Ali Ahmad

   pp. 194–198 · DOI: 10.4103/0976-500X.195920 · Published 2016

   Dry eye disease (DED) is an inflammatory disorder of ocular surfaces leading to severe disability, especially in the elderly age group. The mainstay of therapy includes artificial tears, punctual plugs, topical anti- inf…

Research Letter

1. Article

   Analgesics self-medication among undergraduate students of a Rural Medical College

   Amit Kumar, Vandana Vandana, Ahmad Nadeem Aslami

   pp. 182–3 · DOI: 10.4103/0976-500X.195903 · Published 26 October 2016

   The data were analyzed by descriptive and inferential statistics. Odds ratio and Chi-square test were applied. The sum of percentages is not always 100% as some questions contained multiple responses. A total of 308 comp…