Volume 8, Issue 1

2017 · pp. 1–43 · 10 articles

Volume: 8
Issue: 1
Published: 2017
Pages: 1–43
Articles: 10
Sections: 4
ISSN: ISSN: Print - 0976-500X, Online - 0976-5018
Journal: J Pharmacol. Pharmacother.

Editorial Research Paper Research Letter Case Report

In this issue

Editorial

Forum Article
Eminence or Evidence? The Volatility, Uncertainty, Complexity, and Ambiguity in Healthcare
M. K. Unnikrishnan
pp. 1–2 · DOI: 10.4103/jpp.JPP_12_17 · Published 2017
Today’s digital revolution is forcing the healthcare practitioner to read too much, but learn very little. Contemporary knowledge systems have disintegrated into minutiae, focusing more and more on intricacies devoid of …

Research Paper

Article
Indocyanine Green-001 (ICG-001) Attenuates Wnt/β-catenininduces Myocardial Injury Following Sepsis
Nasser Ghaly Yousif, Najah R. Hadi, Alaa Manea Hassan
pp. 14–20 · DOI: 10.4103/jpp.JPP_153_16 · Published 2017
Objective: To investigate the mechanistic pathway of both indocyanine green (ICG)‑001 in attenuated endotoxemia‑induced cardiac depression through downregulation cardiac Wnt/ β‑catenin cell signaling. Materials and Metho…
Article
Antianginal Efficacy and Tolerability of Ranolazine as an Add‑on Drug to Concomitant Medications Primarily Metoprolol in Chronic Stable Angina Patients: A Prospective, Open‑Label Study
Anant Mahaveer Khot, H. V. Anuradha, V. S. Prakash, M. C. Shivamurathy
pp. 21–27 · DOI: 10.4103/jpp.JPP_168_16 · Published 2017
Objective: To evaluate the efficacy and tolerability of ranolazine as an add‑on drug in chronic stable angina patients and the impact of ranolazine on the quality of life in chronic stable angina patients receiving other…
Article
Risperidone-Induced Adverse Drug Reactions and Role of DRD2 (−141 C Ins/Del) and 5HTR2C (−759 C>T) Genetic Polymorphisms in Patients with Schizophrenia
Charanraj Goud Alladi, Anbarasan Mohan, Deepak Gopal Shewade, Ravi Philip Rajkumar, Surendiran Adithan, Karthick Subramanian
pp. 28–32 · DOI: 10.4103/jpp.JPP_197_16 · Published 2017
Objective: To determine the adverse drug reaction (ADR) profile of risperidone and their association with dopamine (DRD2 − 141 C Ins/ Del/rs1799732) and serotonin receptor (5HTR2C −759 C>T/rs3813929) gene polymorphisms i…
Article
Effect of Addition of Fentanyl and Clonidine to Local Anesthetic Solution in Peribulbar Block
Poonam Nehra, Vrinda Oza, Vandana Parmar, Pooja Fumakiya
pp. 3–7 · DOI: 10.4103/jpp.JPP_109_16 · Published 2017
Objective: To compare the effect of addition of fentanyl and clonidine as adjuvants to bupivacaine and lignocaine in peribulbar block. Methods: The study was conducted on 105 adult patients of either sex, of ASA grade I …
Article
Mechanism Underlying Linezolid‑induced Thrombocytopenia in a Chronic Kidney Failure Mouse Model
Nao Nishijo, Yasuhiro Tsuji, Kazuhisa Matsunaga, Masahiko Kutsukake, Fumiyasu Okazaki, Shiro Fukumori, Hidefumi Kasai, Yoichi Hiraki, Ippei Sakamaki, Yoshihiro Yamamoto, Yoshiharu Karube, Hideto To
pp. 8–13 · DOI: 10.4103/jpp.JPP_167_16 · Published 2017
Objective: To investigate the relationship between renal function and linezolid (LZD)‑induced thrombocytopenia and elucidate the underlying mechanism using a chronic renal disease (CRD) mouse model. Materials and Methods…

Research Letter

Article
Methylcobalamin in Vitamin B12 Deficiency: To Give or not to Give?
Ashwin Kamath, Sudhakar Pemminati
pp. 33–34 · DOI: 10.4103/jpp.JPP_173_16 · Published 2017
Sir, Vitamin B12 deficiency is a common nutritional disorder characterized by hematological and neurological manifestations. Cyanocobalamin (CNCbl) or hydroxocobalamin (OHCbl) have been the traditional B12 formulations r…

Case Report

Article
Severe Bone Marrow Suppression Accompanying Pulmonary Infection and Hemorrhage of the Digestive Tract Associated with Leflunomide and Low-dose Methotrexate Combination Therapy
Caihong Qu, Ying Lu, Weimin Liu
pp. 35–37 · DOI: 10.4103/jpp.JPP_93_16 · Published 2017
A 60-year-old male patient developed hyperpyrexia, cough, expectoration with blood-stained sputum, mouth ulcers, and suppurative tonsillitis after receiving 35 days of combination treatment with leflunomide (LEF) and low…
Article
Ifosfamide-induced Encephalopathy Precipitated by Aprepitant: A Rarely Manifested Side Effect of Drug Interaction
Pritam Sureshchandra Kataria, Pradip Piraji Kendre, Apurva A. Patel
pp. 38–40 · DOI: 10.4103/jpp.JPP_182_16 · Published 2017
Central nervous system (CNS) toxicity has been reported in approximately 10%–30% of patients receiving intravenous infusions of ifosfamide. Encephalopathy is a rare but serious CNS adverse reaction in these patients, and…
Article
Pleural Tuberculosis following Infliximab Therapy for Ankylosing Spondylitis
V. S. Gokul Krishnan, Sharath Madhyastha, Kusugodlu Ramamoorthi, Raviraj V. Acharya, Vinaya Gopalaswamy
pp. 41–43 · DOI: 10.4103/jpp.JPP_174_16 · Published 2017
We present a case of pleural tuberculosis (TB) in a patient on infliximab for ankylosing spondylitis. A 36-year-old male presented to our hospital with low back ache of inflammatory type along with multiple symmetric inf…