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    Review

    Silymarin: A Historical and Scientific Exploration of its Medicinal Properties

    Hebbani Nagarajappa Shivaprasad1, Vinaya Gharabude1, Sravani Thimmannagari1★, Madhu Krishnamani1, Gaurav Soni1★ Corresponding author

    1. 1Research and Development Centre, Botanic Healthcare Pvt. Ltd., TSIIC Industrial Development Area, Nacharam, Uppal, Hyderabad, Telangana, INDIA.

    CORRESPONDENCE

    Sravani Thimmannagari

    Research and Development Centre, Botanic Healthcare Pvt. Ltd., TSIIC Industrial Development Area, Nacharam, Uppal, Hyderabad, Telangana, INDIA.

    research1@botanichealthcare.net

    Received: 17-11-2024; Revised: 05-01-2025; Accepted: 29-04-2025.

    Volume 19, Issue 37 · pp. 102–108 · PUBLISHED · DOI: 10.5530/phrev.20250002

    View on Pharmacogn. Rev. original site ↗

    ABSTRACT

    Silybum marianum, or milk thistle, has been used medicinally for over 2,000 years, mainly to treat liver conditions. Silymarin, a complex mixture of flavonolignans, is present in the plant, which contributes to its pharmacological properties. Silymarin, especially its active compound silybin used particularly for liver health. This review compiles information from databases such as Google Scholar, PubMed, ScienceDirect, and ResearchGate. It is used in traditional medicine to treat liver conditions like cirrhosis and hepatitis, promoting regeneration, reducing oxidative stress, and enhancing detoxification. It also boosts glutathione levels, lowers liver fibrosis, and has been shown to protect the liver from a number of toxins, including alcohol and environmental pollutants. Various research studies confirm its safety with no serious side effects and it has been proven fairly low in toxicity. Further validating its role as a promising therapeutic agent for liver diseases.

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      Shivaprasad, H. N., Gharabude, V., Thimmannagari, S., Krishnamani, M., & Soni, G. (). Silymarin: A Historical and Scientific Exploration of its Medicinal Properties. Pharmacognosy Reviews, 19(37), 102–108. https://doi.org/10.5530/phrev.20250002