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    Review

    Biosynthesis pathways of ginkgolides

    Zihan Zeng1, Jianhua Zhu2, Lili Chen1, Wei Wen1, Rongming Yu1,2★★ Corresponding author

    1. 1Biotechnological Institute of Chinese Materia Medica.
    2. 2College of Pharmacy, Jinan University, Guangzhou, CHINA.

    CORRESPONDENCE

    Rongming Yu

    Biotechnological Institute of Chinese Materia Medica.

    tyrm@jnu.edu.cn

    Received: 17-10-2012; Revised: 28-12-2012; Accepted: 06-05-2013.

    Volume 7, Issue 13 · pp. 47–52 · PUBLISHED 1 June 2013 · DOI: 10.4103/0973-7847.112848

    View on Pharmacogn. Rev. original site ↗

    ABSTRACT

    The ginkgolides, acting as anti‑platelet‑activating factors, have been studied for many years. The biosynthetic pathway of ginkgolides is still far away from unveiling at the level of molecular genetics and biochemistry. There are at least 11 kinds of enzymes having been cloned from Ginkgo biloba L., which catalyze the formation of ginkgolides via a series of reactions. Some researchers have indicated that the addition of precursors and elicitors can influence the accumulation of ginkgolides in the suspension cell cultures of G. biloba. There are also other factors that can influence the production of ginkgolides. This review focuses on the aforementioned aspects to discuss the biosynthetic pathways of the ginkgolides.

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      Zeng, Z., Zhu, J., Chen, L., Wen, W., & Yu, R. (2013). Biosynthesis pathways of ginkgolides. Pharmacognosy Reviews, 7(13), 47–52. https://doi.org/10.4103/0973-7847.112848