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    Article

    Aliphatic and eudesmalolide esters extracted from the roots of Inula racemosa Hook

    Maria Khan1, S.R. Mir1, Abuzar Ali1, Mohammad Yusuf2, Mohammed Ali1★★ Corresponding author

    1. 1Department of Pharmacognosy and Phytochemistry, Phytochemistry Research Laboratory, India.
    2. 2Department of Pharmaceutical Chemistry, Jamia Hamdard, New Delhi, India.

    CORRESPONDENCE

    Mohammed Ali

    Department of Pharmacognosy and Phytochemistry, Phytochemistry Research Laboratory, India.

    maliphyto@gmail.com

    Received: 26-05-2013; Revised: 15-06-2013.

    Volume 10, Issue 37 · pp. 40–46 · PUBLISHED 7 February 2014 · DOI: 10.4103/0973-1296.126657

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Phytochemical investigation of hydroalcoholic extract of the root of Inula racemosa Hook. Materials and Methods: Open silica gel column chromatographic techniques with different solvent systems was used for isolation of aliphatic and eudesmalolide esters from hydroalcoholic extract of the root of Inula racemosa. The structure elucidation of the compounds was done on the basis of spectral data analysis, chemical reactions and comparision with literature data. Results: Phytochemical investigation of the hydroalcoholic extract of the root of Inula racemosa Hook. f. led to the isolation of (5z, 13z)-n-decanyl-n-docos-5, 13-dienoate, a new fatty acid ester, two new sesquiterpenic ester identifi ed as 15-[(13z, 18’z, 20’z)-n-tricos-13, 18, 20-trienyl]-eudesmal-4 (11), 6, 12 (13)-trien-8,14-olide-15-oate and 15- [(16’z), (21’z)-n- tetracos-16’, 21’-dienyl]-eudesmal-4 (11) 6, 12 (13)-trien-8, 14-olide-15-oate, two new eudesmanolide ester i.e. 15-[(16z)-n-monadec-16’-enyl]-eudesmal-4 (11) 6, 12 (13)-trien-8,14-olide-15-oate and 15-[(16’z)-n-tetracos-16’-enyl]-endesmal-4 (11), 6, 12 (13)-trien-8,14-olide-15-oate along with the known compound n-Hexadecanyl n-docosanoate. Conclusion: Five new phytoconstituents were identifi ed along with one known compound as aliphatic and eudesmalolide esters from the hydroalcoholic extract of the root of Inula racemosa, as mentioned above.

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      Khan, M., Mir, S., Ali, A., Yusuf, M., & Ali, M. (2014). Aliphatic and eudesmalolide esters extracted from the roots of Inula racemosa Hook. Pharmacognosy Magazine, 10(37), 40–46. https://doi.org/10.4103/0973-1296.126657