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    Article

    Comparison of pharmacokinetic behavior of two iridoid glycosides in rat plasma after oral administration of crude Cornus officinals and its jiuzhipin by high performance liquid chromatography triple quadrupole mass spectrometry combined with multiple reactions monitoring mode

    Xiaocheng Chen1, Gang Cao2★, Jianping Jiang2★ Corresponding author

    1. 1The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
    2. 2Research Center of TCM Processing Technology, The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, P. R. China, China.

    CORRESPONDENCE

    Gang Cao

    Research Center of TCM Processing Technology, The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, P. R. China, China.

    caogang33@163.com

    Received: 17-06-2013; Revised: 21-07-2013; Accepted: 21-02-2014.

    Volume 10, Issue 37s · pp. S115–S116 · PUBLISHED 21 February 2014 · DOI: 10.4103/0973-1296.127358

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: The present study examined the pharmacokinetic profiles of two iridoid glycosides named morroniside and loganin in rat plasma after oral administration of crude and processed Cornus officinals. Materials and Methods: A rapid, selective and specific high-performance liquid chromatography/electrospray ionization tandem mass spectrometry with multiple reactions monitoring mode was developed to simultaneously investigate the pharmacokinetic profiles of morroniside and loganin in rat plasma after oral administration of crude C. officinals and its jiuzhipin. Results: The morroniside and loganin in crude and processed C. officinals could be simultaneously determined within 7.4 min. Linear calibration curves were obtained over the concentration ranges of 45.45-4800 ng/mL for all the analytes. The intra-and inter-day precisions relative standard deviation was lesser than 2.84% and 4.12%, respectively. Conclusion: The pharmacokinetic parameters of two iridoid glucosides were also compared systematically between crude and processed C. officinals. This paper provides the theoretical proofs for further explaining the processing mechanism of Traditional Chinese Medicines.

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      Chen, X., Cao, G., & Jiang, J. (2014). Comparison of pharmacokinetic behavior of two iridoid glycosides in rat plasma after oral administration of crude Cornus officinals and its jiuzhipin by high performance liquid chromatography triple quadrupole mass spectrometry combined with multiple reactions monitoring mode. Pharmacognosy Magazine, 10(37s), S115–S116. https://doi.org/10.4103/0973-1296.127358