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    Article

    Optimization of quercitrin and total flavonoids extraction from Herba Polygoni Capitati by response surface methodology

    Fengwei Ma1,2, Yang Zhao1,2, Xiaojian Gong1,2, Yu Xie3, Xin Zhou1,2★★ Corresponding author

    1. 1The Research Center for Quality Control of Nature Medicine, Guizhou Nomal University, Guiyang, Guizhou, P.R. China, China.
    2. 2Key Laboratory for Information System of Mountainous Area and Protection of Ecological Environment of Guizhou province, Guizhou Nomal University, Guiyang, Guizhou, P.R. China, China.
    3. 3Guizhou Warmen Pharmaceutical Co., Ltd., Guiyang, Guizhou, P.R. China, China.

    CORRESPONDENCE

    Xin Zhou

    The Research Center for Quality Control of Nature Medicine, Guizhou Nomal University, Guiyang, Guizhou, P.R. China, China.

    alice9800@sina.com

    Received: 11-04-2013; Revised: 08-06-2013; Accepted: 08-06-2013.

    Volume 10, Issue 37s · pp. S57–S58 · PUBLISHED 21 February 2014 · DOI: 10.4103/0973-1296.127343

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: To optimize the conditions for extraction of quercitrin and total flavonoids (TF) from Herba Polygoni Capitati (Touhualiao in Chinese) by using response surface methodology (RSM). Materials and Methods: A central composite design (CCD) was adopted to investigate the effects of three independent variables including solvent composition (%), solvent-material ratio (ml/g) and extraction time (min) on the responses, quercitrin and TF yields. Results: The optimized conditions of the extraction are as follows: Ethanol concentration, 65.63%; solvent-material ratio, 10.55:1 (ml/g); extraction time, 54.33 min. The established mathematical model described the factors of experimental parameters well and provided a statistically accurate prediction of the optimum yields of quercitrin and TF. Conclusion: The experimental values agreed with those predicted by the established mathematical model, thus indicating the suitability of the model employed and the success of RSM in optimizing the extraction conditions.

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      Ma, F., Zhao, Y., Gong, X., Xie, Y., & Zhou, X. (2014). Optimization of quercitrin and total flavonoids extraction from Herba Polygoni Capitati by response surface methodology. Pharmacognosy Magazine, 10(37s), S57–S58. https://doi.org/10.4103/0973-1296.127343