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    Article

    Anti‑inflammatory effects of Cryptotympana atrata Fabricius slough shed on contact dermatitis induced by dinitrofluorobenzene in mice

    Miyoung Kim1★, Hanna Kim1★, Jeonghyun Ryu1, Suzy Jo1, Guemsan Lee2, Mi Heon Ryu3, Hyungwoo Kim1★ Corresponding author

    1. 1Su In Cho Division of Pharmacology, School of Korean Medicine, Pusan National University, Gyeongnam.
    2. 2Department of Herbology, College of Korean Medicine, Wonkwang University, Jeonbuk.
    3. 3Department of Oral Pathology, School of Dentistry, Pusan National University, Gyeongnam, South Korea.

    CORRESPONDENCE

    Miyoung Kim

    Su In Cho Division of Pharmacology, School of Korean Medicine, Pusan National University, Gyeongnam.

    kronos7@pusan.ac.kr

    Received: 20-10-2013; Revised: 16-12-2013.

    Volume 10, Issue 38s · pp. 377–382 · PUBLISHED 28 May 2014 · DOI: 10.4103/0973-1296.133288

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The slough shed of Cryptotympana atrata Fabricius is widely used to treat skin diseases in China, Japan, and Korea. Objective: To investigate the anti‑inflammatory effects of C. atrata on contact dermatitis. Materials and Methods: We investigated the effects of C. atrata methanol extract (MECA) on ear swelling, histophathological changes and cytokine production in 1‑fluoro‑2,4‑dinitrofluorobenzene (DNFB)‑induced contact dermatitis (CD) mice. Results: Topical application of MECA effectively inhibited enlargement of ear swelling (30 and 100 m/ear, P < 0.05; 300 mg/ear, P < 0.01). MECA treatment also inhibited hyperplasia, spongiosis (100 and 300 mg/ear, P < 0.001), and immune cell infiltration (30 mg/ear, P < 0.05; 100 and 300 mg/ear, P < 0.001) induced by DNFB. In addition, treatment with MECA suppressed the increase in the levels of TNF‑a (P < 0.05), IFN‑g (3, 100 mg/ear, P < 0.05; 300 mg/ear, P < 0.01), and IL‑6 (100 mg/ear, P < 0.05; 300 mg/ear, P < 0.01) production. Conclusion: These data suggest that MECA has the potential for use in the treatment of inflammatory skin diseases, including CD. Moreover, the results presented herein indicate that anti‑inflammatory actions of MECA are mediated by decreasing production of TNF‑α, IFN‑g, and IL‑6 in inflamed tissues.

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      Kim, M., Kim, H., Ryu, J., Jo, S., Lee, G., Ryu, M. H., & Kim, H. (2014). Anti‑inflammatory effects of Cryptotympana atrata Fabricius slough shed on contact dermatitis induced by dinitrofluorobenzene in mice. Pharmacognosy Magazine, 10(38s), 377–382. https://doi.org/10.4103/0973-1296.133288