Volume 10, Issue 38s

Revisiting “Vegetables” to combat modern epidemic of imbalanced glucose homeostasis

Ashok Kumar Tiwari

pp. S207–S208 · DOI: 10.4103/0973-1296.133211 · Published 28 May 2014

Vegetables have been part of human food since prehistoric times and are considered nutritionally necessary and good for health. Vegetables are rich natural resource of biological antioxidants and possess capabilities of …

Aqueous extract from taxus baccata inhibits adenosine deaminase activity significantly in cancerous and noncancerous human gastric and colon tissues

Zahide Esra Durak, Süleyman Büber, Erdinç Devrim, Hilmi Kocaoğlu2, İlker Durak

pp. 214–216 · DOI: 10.4103/0973-1296.133232 · Published 28 May 2014

Objective: To investigate possible effects of aqueous taxus baccata extract on adenosine deaminase (ADA) activity in cancerous and noncancerous human tissues and to clarify mechanism(s) of its anticancer potential. Mater…

Chitosan and blueberry treatment induces arginase activity and inhibits nitric oxide production during acetaminophen‑induced hepatotoxicity

Eda Ozcelik, Sema Uslu, Dilek Burukoglu, Ahmet Musmul

pp. 217–224 · DOI: 10.4103/0973-1296.133234 · Published 28 May 2014

Background: Liver diseases have become a major problem of the worldwide. More than 50% of all cases of liver failure can be attributed to drugs. Among these, acetaminophen is the most common cause. Objective: The aim of …

Efficiency and selectivity of triterpene acid extraction from decoctions and tinctures prepared from apple peels

Antonio C. Siani, Marcos J. Nakamura, Daniel S. dos Santos, José L. Mazzei, Adriana C. do Nascimento, Ligia M. M. Valente

pp. 225–231 · DOI: 10.4103/0973-1296.133236 · Published 28 May 2014

Background: This study assessed the extraction efficiency of ursolic (UA) and oleanolic acids (OA), as well as the total phenols in aqueous and hydroethanolic extracts of dry apple peels at room temperature. Materials an…

Antiproliferative activity of Vallaris glabra Kuntze (Apocynaceae)

Siu Kuin Wong, Yau Yan Lim, Sui Kiong Ling, Eric Wei Chiang Chan

pp. 232–239 · DOI: 10.4103/0973-1296.133238 · Published 28 May 2014

Background: Our earlier study on the antiproliferative (APF) activity of leaf extracts of ten Apocynaceae species showed that leaves of Vallaris glabra possessed strong and broad‑spectrum properties. Materials and Method…

Inhibition of LDL oxidation and oxidized LDL‑induced foam cell formation in RAW 264.7 cells show anti‑atherogenic properties of a foliar methanol extract of Scoparia dulcis

Sinjitha S. Nambiar, Nandini Prasad Shetty, Praveena Bhatt, Bhagyalakshmi Neelwarne

pp. 240–248 · DOI: 10.4103/0973-1296.133241 · Published 28 May 2014

Background: Oxidation of low density lipoproteins and their further uptake by macrophages is known to result in the formation of foam cells, which are critical in the initiation of atherosclerosis through activation of i…

Neuroprotective and cognitive enhancing activity of the fermented Bozhougyiqi‑Tang

Jin Bae Weon, Bohyoung Lee, Bo‑Ra Yun, Jiwoo Lee, Jin Yeul Ma, Choong Je Ma

pp. 249–255 · DOI: 10.4103/0973-1296.133266 · Published 28 May 2014

Background: Alzheimer’s disease is a neurodegenerative disease related to memory impairments and neuronal cell death. Bozhougyiqi‑Tang (BZYQT), a traditional herbal medicine, has been therapeutically used for the treatme…

Simultaneous determination of 11 bioactive compounds in Jaeumganghwa‑tang by high performance liquid chromatography‑diode array detection

Bo‑Ra Yun, Jin Bae Weon, Jiwoo Lee, Min Rye Eom, Choong Je Ma

pp. 256–263 · DOI: 10.4103/0973-1296.133267 · Published 28 May 2014

Background: Jaeumganghwa‑tang (JEGH) is a traditional Korean herbal medicine for the treatment of chronic bronchitis, nephritis and diabetes mellitus. Objective: A high performance liquid chromatography‑diode array detec…

Molecular docking studies of flavonoids for their inhibition pattern against β‑catenin and pharmacophore model generation from experimentally known flavonoids to fabricate more potent inhibitors for Wnt signaling pathway

Hira Iftikhar, Sajid Rashid

pp. 264–271 · DOI: 10.4103/0973-1296.133269 · Published 28 May 2014

Background: Canonical Wnt signaling plays a key role in tumor cell proliferation, which correlates with the accumulation of β‑catenin in cell due to inactivation of glycogen synthetase kinase‑3 β. However, uncontrolled e…

Inhibitory effects of ginseng seed on melanin biosynthesis

Yeonmi Lee, Kyoung‑Tack Kim, Sung Soo Kim, Jinyoung Hur, Sang Keun Ha, Chang‑Won Cho

pp. 272–275 · DOI: 10.4103/0973-1296.133271 · Published 28 May 2014

Background: Ginseng root has been traditionally used for the treatment of many diseases in Korea. However, so far ginseng seed has been mostly unused and discarded. As part of our ongoing research on the ginseng seeds, t…

Anti‑cholinesterase activity of the standardized extract of Syzygium aromaticum L.

Manoj K. Dalai, Santanu Bhadra, Sushil K. Chaudhary, Arun Bandyopadhyay, Pulok K. Mukherjee

pp. 276–282 · DOI: 10.4103/0973-1296.133275 · Published 28 May 2014

Background: Clove (Syzygium aromaticum) is a well‑known culinary spice with strong aroma; contains a high amount of oil known as clove oil. The major phyto‑constituent of the clove oil is eugenol. Clove and its oil posse…

Pharmacodynamic studies on the isolated active fraction of Acacia farnesiana (L.) willd

Bino Kingsley, Saminathan Kayarohanam, Pemaiah Brindha, Appian Subramoniam

pp. 283–287 · DOI: 10.4103/0973-1296.133277 · Published 28 May 2014

Background: Acacia farnesiana is a medicinal plant that grows throughout tropical parts of Indian subcontinent, particularly in sandy soils of river beds in Northern India. The objective of the present study was to evalu…

Quantification of allicin by high performance liquid chromatography‑ultraviolet analysis with effect of post‑ultrasonic sound and microwave radiation on fresh garlic cloves

Sankhadip Bose, Bibek Laha, Subhasis Banerjee

pp. 288–293 · DOI: 10.4103/0973-1296.133279 · Published 28 May 2014

Background: Garlic (Allium sativum L.) has been accepted universally to be applied in food, spice and traditional medicine. The medicinal and other beneficial properties of garlic are attributed to organosulfur compounds…

Screening of siddha medicinal plants for its in‑vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity

Madhuri Kadiyala, Sivasankaran Ponnusankar, Kannan Elango

pp. 294–298 · DOI: 10.4103/0973-1296.133281 · Published 28 May 2014

Background: The plants selected for the study were traditionally used in siddha system of medicine in neurological disorders. Aim: The aim of the following study isto screen the plant species for both acetylcholinesteras…

Efficacy of Acorus calamus on collagen maturation on full thickness cutaneous wounds in rats

Thangavel Ponrasu, Karuppanan Natarajan Madhukumar, Moorthy Ganeshkumar, Kuttalam Iyappan, Vilvanathan Sangeethapriya, Vinaya Subramani Gayathri, Lonchin Suguna

pp. 299–305 · DOI: 10.4103/0973-1296.133283 · Published 2014

Background: The rhizomes of Acorus calamus and their essential oil are widely used in the flavoring industry and production of alcoholic beverages in Europe. Recent reports have confirmed the presence of several pharmaco…

Luteolin, a biofl avonoid inhibits azoxymethane-induced colon carcinogenesis: Involvement of iNOS and COX-2

Ashok Kumar Pandurangan, Suresh Kumar Ananda Sadagopan, Prakash Dharmalingam

pp. 306–310 · DOI: 10.4103/0973-1296.133285 · Published 28 May 2014

An attempt to stabilize tanshinone IIA solid dispersion by the use of ternary systems with nano‑CaCO3 and poloxamer 188

Hong‑mei Yan, Zhen‑hai Zhang, Yan‑rong Jiang, Dong‑mei Ding, E. Sun, Xiao‑bin Jia

pp. 311–317 · DOI: 10.4103/0973-1296.133286 · Published 28 May 2014

Background: Tanshinone IIA (TSIIA) on solid dispersions (SDs) has thermodynamical instability of amorphous drug. Ternary solid dispersions (tSDs) can extend the stability of the amorphous form of drug. Poloxamer 188 was …

Optimization of Ultrasound-assisted extraction of polyphenols, tannins and epigallocatechin gallate from barks of Stryphnodendron adstringens (Mart.) Coville bark extracts

Jordana N. Sousa, Nathália B. Pedroso, Leonardo L. Borges, Gerlon A. R. Oliveira, José R. Paula

pp. 318–323 · DOI: 10.4103/0973-1296.133287 · Published 2014

Background: Stryphnodendron adstringens (Mar.) Coville is a native plant from Brazil, rich in phenolic compounds and used on popular medicine as a wound healing agent, in the treatment of gastric lesions and as antimicro…

Isolation and identification of cytotoxic compounds from the rhizomes of Paris quadrifolia L.

Jerzy Gajdus, Zbigniew Kaczyński, Anna Kawiak, Ewa Łojkowska, Justyna Stefanowicz-Hajduk, J. Renata Ochocka, Piotr Stepnowski

pp. 324–333 · DOI: 10.4103/0973-1296.133289 · Published 28 May 2014

Background: Paris quadrifolia L. is a medicinal plant which contains steroidal saponins. The present study reports isolation and structural identification of six pennogenyl saponins obtained from P. quadrifolia rhizomes.…

Cytotoxic neviotane triterpene‑type from the red sea sponge Siphonochalina siphonella

Rihab F. Angawi, Esraa Saqer, Ahmed Abdel‑Lateff, Farid A. Badria, Seif‑Eldin N. Ayyad

pp. 334–341 · DOI: 10.4103/0973-1296.133292 · Published 28 May 2014

Background: Siphonochalina siphonella is a marine sponge collected from saudi Red Sea water and scare study from this region. Objective: To isolate the anticancer triterpenes with potent cytotoxicity from marine sponge, …

Two novel antifungals, acornine 1 and acornine 2, from the bark of mangrove plant Aegiceras corniculatum (Linn.) Blanco from Sundarban Estuary

Vinod K. Gupta, Kalishankar Mukherjee, Amit Roy

pp. 342–349 · DOI: 10.4103/0973-1296.133293 · Published 28 May 2014

Background: Microbes have been implicated in a wide variety of human diseases many of which are of life‑threatening nature. New antimicrobials are urgently needed not only for combating these organisms but also to counte…

Dietary supplementation of chloroquine with nigella sativa seed and oil extracts in the treatment of malaria induced in mice with plasmodium berghei

Promise Madu Emeka, Lorina Ineta Badger‑Emeka, Chiamaka Maryann Eneh, Tahir Mahmood Khan

pp. 357–362 · DOI: 10.4103/0973-1296.133282 · Published 2014

Background: The aim of the study was to investigate the effects of dietary combination of Nigella sativa seed and oil extracts with chloroquine (CQ), and how these combinations enhance CQ efficacy in mice infected with P…

Pyrostegia venusta heptane extract containing saturated aliphatic hydrocarbons induces apoptosis on B16F10‑Nex2 melanoma cells and displays antitumor activity in vivo

Carlos R. Figueiredo, Alisson L. Matsuo, Felipe V. Pereira, Aline N. Rabaça, Camyla F. Farias, Natália Girola, Mariana H. Massaoka, Ricardo A. Azevedo, Jorge A.B. Scutti, Denise C. Arruda, Luciana P. Silva, Elaine G. Rodrigues, João Henrique G. Lago, Luiz R. Travassos, Regildo M.G. Silva

pp. 363–376 · DOI: 10.4103/0973-1296.133284 · Published 28 May 2014

Background: Pyrostegia venusta (Ker. Gawl.) Miers (Bignoniacea) is a medicinal plant from the Brazilian Cerrado used to treat leucoderma and common diseases of the respiratory system. Objective: To investigate the antitu…

Anti‑inflammatory effects of Cryptotympana atrata Fabricius slough shed on contact dermatitis induced by dinitrofluorobenzene in mice

Miyoung Kim, Hanna Kim, Jeonghyun Ryu, Suzy Jo, Guemsan Lee, Mi Heon Ryu, Hyungwoo Kim

pp. 377–382 · DOI: 10.4103/0973-1296.133288 · Published 28 May 2014

Background: The slough shed of Cryptotympana atrata Fabricius is widely used to treat skin diseases in China, Japan, and Korea. Objective: To investigate the anti‑inflammatory effects of C. atrata on contact dermatitis. …

Vegetables’ juice influences polyol pathway by multiple mechanisms in favour of reducing development of oxidative stress and resultant diabetic complications

Ashok K. Tiwari, D. Anand Kumar, Pisupati S. R. Sweeya, H. Anusha Chauhan, V. Lavanya, K. Sireesha, K. Pavithra, Amtul Zehra

pp. 383–391 · DOI: 10.4103/0973-1296.133290 · Published 28 May 2014

Objective: Hyperglycemia induced generation of free radicals and consequent development of oxidative stress by polyol pathway is one of the crucial mechanisms stirring up development of diabetic complications. We evaluat…

In Vivo skin hydration and anti‑erythema effects of Aloe vera, Aloe ferox and Aloe marlothii gel materials after single and multiple applications

Lizelle T. Fox, Jeanetta du Plessis, Minja Gerber, Sterna van Zyl, Banie Boneschans, Josias H. Hamman

pp. 392–403 · DOI: 10.4103/0973-1296.133291 · Published 28 May 2014

Objective: To investigate the skin hydrating and anti‑erythema activity of gel materials from Aloe marlothii A. Berger and A. ferox Mill. in comparison to that of Aloe barbadensis Miller (Aloe vera) in healthy human volu…

Evaluation of antidiabetic, antioxidant and antiglycating activities of the Eysenhardtia polystachya

Rosa Martha Perez Gutierrez, Efren Garcia Baez

pp. 404–418 · DOI: 10.4103/0973-1296.133295 · Published 28 May 2014

Background: Many diseases are associated with oxidative stress caused by free radicals. The aim of the present study was to evaluate the antidiabetic, antioxidant and antiglycation properties of Eysenhardtia polystachya …

Anti-tumor activity of safranal against neuroblastoma cells

Saeed Samarghandian, Mohammad Ebrahim Shoshtari, Javad Sargolzaei, Hosna Hossinimoghadam, Jabbari Azad Farahzad

pp. 419–424 · DOI: 10.4103/0973-1296.133296 · Published 28 May 2014

Objective: Safranal (2,6,6-trimethyl-1,3-cyclohexadiene-1-carboxaldehyde, C10H14O) is an active ingredient in the saffron, which is used in traditional medicine, and also, the biological activity of saffron in anti-cance…

Effect of ultrasound on the isoflavonoid production in Genista tinctoria L. suspension cultures

Lenka Tůmová, Jiří Tůma, Helena Hendrychová

pp. 425–429 · DOI: 10.4103/0973-1296.133297 · Published 28 May 2014

Background: Application of ultrasound (US) to biotechnology is relatively new but several processes that take place in the presence of cells or enzymes are activated by ultrasonic waves. Genista tinctoria L. (Fabaceae) i…

Cytotoxicity of gypsogenic acid isolated from Gypsophila trichotoma

Ilina Krasteva, Maya Yotova, Deyan Yosifov, Niko Benbassat, Kristina Jenett‑Siems, Spiro Konstantinov

pp. 430–433 · DOI: 10.4103/0973-1296.133299 · Published 28 May 2014

Background: Gypsophila trichotoma Wend. (Caryophyllaceae) is a medicinal plant which is protected in Bulgaria by the Biodiversity Law. Previous studies have showed the presence of triterpene saponins, sterols, flavonoids…

Phytochemical and anti‑staphylococcal biofilm assessment of Dracaena draco L. Spp. draco resin

V. Di Stefano, R. Pitonzo, D. Schillaci

pp. 434–440 · DOI: 10.4103/0973-1296.133300 · Published 28 May 2014

Background: Dracaena draco L. ssp. draco is known as the “dragon’s blood tree” and it is endemic from the Canary Islands and Morocco. Objective: Carry out phytochemical investigation of acetonic extracts of red resin obt…

Hemostatic, milk clotting and blood stain removal potential of cysteine proteases from Calotropis gigantea (L.) R. Br. Latex

Omana Sukumaran Bindhu, Maheshwari Kumari Singh

pp. S350–S351 · DOI: 10.4103/0973-1296.133294 · Published 28 May 2014

Introduction: Plant latex is a natural source of biologically active compounds and several hydrolytic enzymes responsible for their diverse health benefits. Recent past has witnessed substantial progress in understanding…

The evolution of pharmacognosy in Iran, challenges, and developments

Soodabeh Saeidnia

pp. S441–S442 · DOI: 10.4103/0973-1296.133298 · Published 2014

Pharmacognosy is delineated as an area of pharmacy involved with the medicinal plants, natural pharmaceutical products, extraction and purification of natural drugs, and rational application of traditional medicines. Pha…