Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    In Vivo skin hydration and anti‑erythema effects of Aloe vera, Aloe ferox and Aloe marlothii gel materials after single and multiple applications

    Lizelle T. Fox1, Jeanetta du Plessis1, Minja Gerber1, Sterna van Zyl2, Banie Boneschans2, Josias H. Hamman1★★ Corresponding author

    1. 1Centre of Excellence for Pharmaceutical Sciences, South Africa.
    2. 2Centre for Pharmaceutical and Biomedical Services, Faculty of Health Sciences, North‑West University, Private Bag X6001, Potchefstroom, 2520, South Africa.

    CORRESPONDENCE

    Josias H. Hamman

    Centre of Excellence for Pharmaceutical Sciences, South Africa.

    Sias.Hamman@nwu.ac.za

    Received: 30-09-2013; Revised: 28-10-2013.

    Volume 10, Issue 38s · pp. 392–403 · PUBLISHED 28 May 2014 · DOI: 10.4103/0973-1296.133291

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: To investigate the skin hydrating and anti‑erythema activity of gel materials from Aloe marlothii A. Berger and A. ferox Mill. in comparison to that of Aloe barbadensis Miller (Aloe vera) in healthy human volunteers. Materials and Methods: Aqueous solutions of the polisaccharidic fractions of the selected aloe leaf gel materials were applied to the volar forearm skin of female subjects. The hydration effect of the aloe gel materials were measured with a Corneometer® CM 825, Visioscan® VC 98 and Cutometer® dual MPA 580 after single and multiple applications. The Mexameter® MX 18 was used to determine the anti‑erythema effects of the aloe material solutions on irritated skin areas. Results: The A. vera and A. marlothii gel materials hydrated the skin after a single application, whereas the A. ferox gel material showed dehydration effects compared to the placebo. After multiple applications all the aloe materials exhibited dehydration effects on the skin. Mexameter® readings showed that A. vera and A. ferox have anti‑erythema activity similar to that of the positive control group (i.e. hydrocortisone gel) after 6 days of treatment. Conclusion: The polysaccharide component of the gel materials from selected aloe species has a dehydrating effect on the skin after multiple applications. Both A. vera and A. ferox gel materials showed potential to reduce erythema on the skin similar to that of hydrocortisone gel.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Fox, L. T., Plessis, J. D., Gerber, M., Zyl, S. V., Boneschans, B., & Hamman, J. H. (2014). In Vivo skin hydration and anti‑erythema effects of Aloe vera, Aloe ferox and Aloe marlothii gel materials after single and multiple applications. Pharmacognosy Magazine, 10(38s), 392–403. https://doi.org/10.4103/0973-1296.133291