Enhanced dissolution and stability of Tanshinone IIA base by solid dispersion system with nano‑hydroxyapatite

ABSTRACT

Background: Tanshinone IIA (TSIIA) exhibits a variety of cardiovascular effects; however, it has low solubility in water. The preparation of poorly soluble drugs for oral delivery is one of the greatest challenges in the field of formulation research. Among the approaches available, solid dispersion (SD) technique has proven to be one of the most commonly used these methods for improving dissolution and bioavailability of drugs, because of its relative simplicity and economy in terms of both preparation and evaluation. Objective: This study was aimed at investigating the dissolution behavior and physical stability of SDs of TSIIA by employing nano‑hydroxyapatite (n‑HAp). Materials and Methods: The TSIIA SDs was prepared to use a spray‑drying method. First, an in vitro dissolution test was performed to assess dissolution characteristics. Next, a set of complementary techniques (differential scanning calorimetry, scanning electron microscopy, X‑ray powder diffraction, and Fourier transform infrared spectroscopy) was used to monitor the physicochemical properties of the SDs. The SDs was stored at 40°C/75% relative humidity for 6 months, after which their stability was assessed. Results: TSIIA dissolution remarkably improved because of the formulation of the SDs with n‑HAp particles. Comparisons with the corresponding physical mixtures revealed changes in the SDs and explained the formation of the amorphous phase. In the stability test, virtually no time‑dependent decrease was observed in either in vitro drug dissolution or drug content. Conclusion: SD formulation with n‑HAp may be a promising approach for enhancing the dissolution and stability of TSIIA.

KEYWORDS

• Dissolution
• nano‑hydroxyapatite
• solid dispersion
• stability
• Tanshinone IIA

Showing references and in-text citations exactly as published.

• DOI10.4103/0973-1296.137375Copy

RELATED ARTICLES

Matched on section and article type within this issue of Pharmacogn. Mag..

• Article · VOLUME 10, ISSUE 39Direct proof by 13C‑nuclear magnetic resonance of semi‑purified extract and isolation of ent‑Catechin from leaves of Eucalyptus cinereaSayonara Mendes Silva, Simone Yae Abe, Fernanda Giacomini Bueno, Norberto Peporine Lopes, João Carlos Palazzo de Mello, Tomoe Nakashima · pp. 191–194Original ArticleSame type: Article
• Article · VOLUME 10, ISSUE 39Simultaneous determination of four neuroprotective compounds of Tilia amurensis by high performance liquid chromatography coupled with diode array detectorBohyung Lee, Jin Bae Weon, Bo‑Ra Yun, Jiwoo Lee, Min Rye Eom, Choong Je Ma · pp. 195–199Original ArticleSame type: Article
• Article · VOLUME 10, ISSUE 39Comparison of toad skins Bufo bufo gargarizans Cantor from different regions for their active constituents content and cytotoxic activity on lung carcinoma cell linesCongyan Liu, Wei Cao, Yan Chen, Ding Qu, Jing Zhou · pp. 207–212Original ArticleSame type: Article
• Article · VOLUME 10, ISSUE 39New Sesquiterpene and Polymethoxy‑Flavonoids from Artemisia annua LYang Chu, Hongbo Wang, Jing Chen, Yue Hou · pp. 213–216Original ArticleSame type: Article