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    Strophanthus hispidus attenuates the Ischemia‑Reperfusion induced myocardial Infarction and reduces mean arterial pressure in renal artery occlusion

    Rohit Gundamaraju2,3★, Ravi Chandra Vemuri2, Rajeev K Singla4, Rishya Manikam5, Ranga Rao A6, Shamala Devi Sekaran7★ Corresponding author

    1. 1Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
    2. 2Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhullapally (Post via Hakinpet), Secunderabad, AP.
    3. 3Department of Biotechnology, Netaji Subhas Institute of Technology, Azad Hind Fauz Marg, Sector-3, Dwarka, New Delhi, India.
    4. 4Department of Trauma and Emergency, University Malaya Medical Center, 59100 Kuala Lumpur.
    5. 5Institute of Ocean and Earth Sciences, University of Malaya.
    6. 6Department of Medical Microbiology, Faculty if Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

    CORRESPONDENCE

    Rohit Gundamaraju

    Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dhullapally (Post via Hakinpet), Secunderabad, AP.

    Received: 06-05-2014; Revised: 19-06-2014.

    Volume 10, Issue 39 · pp. 557–562 · PUBLISHED 2014 · DOI: 10.4103/0973-1296.139782

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The myocardium is generally injured in the case of reperfusion injury and arterial damage is caused by hypertension. In reference to these statements, the present study was focused. Cardiac glycosides were said to have protective effects against myocardial infarction and hypertension. Strophanthus hispidus was thus incorporated in the study. Objective: The prime objective of the study was to investigate the protective effects of Strophanthus hispidus against ischemia‑reperfusion myocardial Infarction and renal artery occluded hypertension in rats. Materials and Methods: The animal model adopted was surgically‑induced myocardial ischemia, performed by means of left anterior descending coronary artery occlusion (LAD) for 30 min followed by reperfusion for another 4 h. Infarct size was assessed by using the staining agent TTC (2,3,5‑triphenyl tetrazolium chloride). Hypertension was induced by clamping the renal artery with renal bulldog clamp for 4 h. Results: The study was fruitful by the effect of Strophanthus hispidus on infarction size, which got reduced to 27.2 ± 0.5and 20.0 ± 0.2 by 500 mg/Kg and 1000 mg/Kg ethanolic extracts which was remarkably significant when compared with that of the control group 52.8 ± 4.6. The plant extract did reduce heart rate at various time intervals. There was also a protective effect in the case of mean arterial blood pressure were the 500 mg/Kg and 1000 mg/Kg of the plant extract did reduce the hypertension after 60 minutes was 60.0 ± 4.80 and 50.50 ± 6.80. Conclusion: The results suggest that 500 mg/Kg and 100 mg/Kg ethanolic extract of Strophanthus hispidus was found to possess significant cardiac protective and anti‑hypertensive activity.

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      Gundamaraju, R., Vemuri, R. C., Singla, R. K., Manikam, R., A, R. R., & Sekaran, S. D. (2014). Strophanthus hispidus attenuates the Ischemia‑Reperfusion induced myocardial Infarction and reduces mean arterial pressure in renal artery occlusion. Pharmacognosy Magazine, 10(39), 557–562. https://doi.org/10.4103/0973-1296.139782