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    Article

    Effects of Pogostemon cablin Blanco extract on hypoxia induced rabbit cardiomyocyte injury

    Chi‑Yeon Lim1, Bu‑Yeo Kim2, Se‑Hyun Lim3, Su‑In Cho4★★ Corresponding author

    1. 1Department of Medicine, College of Medicine, Dongguk University, Ilsan 305‑701.
    2. 2Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 305‑701.
    3. 3Department of Nursing, School of Public Health, Far East University, Chungbuk 369‑700.
    4. 4Department of Korean Medicine, School of Korean Medicine, Pusan National University, Yangsan, Gyeongnam 626‑870, Republic of Korea.

    CORRESPONDENCE

    Su‑In Cho

    Department of Korean Medicine, School of Korean Medicine, Pusan National University, Yangsan, Gyeongnam 626‑870, Republic of Korea.

    sicho@pusan.ac.kr

    Received: 03-06-2014; Revised: 18-07-2014.

    Volume 11, Issue 42 · pp. 311–319 · PUBLISHED 12 March 2015 · DOI: 10.4103/0973-1296.153084

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Pogostemonis Herba, the dried aerial part of Pogostemon cablin Blanco, is a well‑known materia medica in Asia that is widely used for syndrome of gastrointestinal dysfunctions. Objective: This study was undertaken to examine whether Pogostemon cablin extract (PCe) might have any beneficial effect on hypoxia induced rabbit cardiomyocyte injury. Materials and Methods: Isolated cardiomyocytes were divided into three groups and the changes of cell viability in cardiomyocytes of hypoxic and hypoxia/reoxygenation group were determined. The effect of PCe on reactive oxygen species (ROS) generation, intracellular formation of ROS was also measured by monitoring the 2’,7’‑dichlorofluorescein fluorescence. Results: PCe effectively protected the cells against both the hypoxia and reoxygenation induced injury, and the protective effect of PCe is not mediated by interaction with adenosine triphosphate‑sensitive K+ channels. In the presence of PCe, production of ROS under chemical hypoxia was remarkably reduced which suggests that PCe might exert its effect as a ROS scavenger. Conclusion: The present study provides clear evidence for the beneficial effect of PCe on cardiomyocyte injury during hypoxia or reoxygenation following prolonged hypoxia.

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      Lim, C., Kim, B., Lim, S., & Cho, S. (2015). Effects of Pogostemon cablin Blanco extract on hypoxia induced rabbit cardiomyocyte injury. Pharmacognosy Magazine, 11(42), 311–319. https://doi.org/10.4103/0973-1296.153084