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    Identity‑based High‑performance thin Layer Chromatography Fingerprinting Profile and Tumor Inhibitory Potential of Anisochilus carnosus (L.f.) wall Against Ehrlich Ascites Carcinoma

    Nilesh Gupta1, Richard Lobo1★, Nimmy Kumar1, Jay Kumar Bhagat1, Jessy Elizabeth Mathew2★ Corresponding author

    1. 1Departments of Pharmacognosy, College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India.
    2. 2Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India.

    CORRESPONDENCE

    Richard Lobo

    Departments of Pharmacognosy, College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India.

    richardlobo73@gmail.com

    Volume 11, Issue 44s2 · pp. 474–480 · PUBLISHED 2015 · DOI: 10.4103/0973-1296.168977

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Context: Anisochilus carnosus (L.f.) wall belonging to the family Lamiaceae is a plant that is widely used in folk medicine for treating eczema, cold, cough, and fever. Objective: In the present study, we explored the anticancer potential of A. carnosus leaves against Ehrlich ascites carcinoma (EAC) and estimated the quantity of luteolin present in various extracts and fractions of A. carnosus by high‑performance thin layer chromatography (HPTLC) fingerprinting. Materials and Methods: Various factors such as tumor volume, tumor cell viability, tumor weight, prolongation of lifespan, and hematological parameters were assessed. Result: We observed a significant lowering in tumor volume, tumor weight, and cell viability in EAC‑induced mice following intervention with A. carnosus extracts. Also, there was a considerable prolongation of host lifespan and restoration of hematological parameters to almost normal levels with A. carnosus treatment. HPTLC fingerprinting of various extracts and fractions of A. carnosus along with luteolin as the reference standard revealed the occurrence of luteolin in all tested extracts and fractions of A. carnosus with the highest concentration being reported in the ethanol fraction. Conclusion: A. carnosus exhibits potent anti‑tumor potential which can most likely be attributed to the occurrence of different phytochemicals such as phytosterols, terpenoids, and flavonoids in the plant. Further studies to isolate compounds from A. carnosus and understand the mechanism of anti‑tumor activity would be worthwhile.

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      Gupta, N., Lobo, R., Kumar, N., Bhagat, J. K., & Mathew, J. E. (2015). Identity‑based High‑performance thin Layer Chromatography Fingerprinting Profile and Tumor Inhibitory Potential of Anisochilus carnosus (L.f.) wall Against Ehrlich Ascites Carcinoma. Pharmacognosy Magazine, 11(44s2), 474–480. https://doi.org/10.4103/0973-1296.168977