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    Article

    Secondary Metabolites from Leaves of Manilkara subsericea (Mart.) Dubard

    Fernanda Borges de Almeida1, Caio Pinho Fernandes1,2★, Wanderson Romao3,4, Gabriela Vanini3, Helber Barcelos Costa3, Hildegardo Seibert França4, Marcelo Guerra Santos5, José Carlos Tavares Carvalho6, Deborah Quintanilha Falcão7, Leandro Rocha2,8★ Corresponding author

    1. 1Laboratório de Nanobiotecnologia Fitofarmacêutica, Colegiado de Farmácia, Universidade Federal do Amapá, Campus Universitário Marco Zero do Equador, Rodovia Juscelino Kubitschek de Oliveira, KM, 02 Bairro Zerão, CEP: 68902-280, Macapá, AP.
    2. 2Programa de Pós, Graduação em Biotecnologia Vegetal, Centro de Ciências da Saúde, Bloco K, 2º Andar, Sala 032, Universidade Federal do Rio de Janeiro, UFRJ, Av. Brigadeiro Trompowski s/n, CEP: 21941-590, Ilha do Fundão, RJ.
    3. 3Laboratório de Petroleômica e Forense, Departamento de Química, Universidade Federal do Espírito Santo, CEP: 29075-910, Vitória, ES.
    4. 4Instituto Federal de Educação, Ciência e Tecnologia do Espírito Santo, CEP: 29106-010, Vila Velha, ES.
    5. 5Faculdade de Formação de Professores, UERJ, Rua: Dr. Francisco Portela, 1470, Patronato, CEP: 24435-005, São Gonçalo, Rio de Janeiro.
    6. 6Laboratório de Pesquisa em Fármacos, Colegiado de Farmácia, Universidade Federal do Amapá, Campus Universitário Marco Zero do Equador, Rod. Juscelino Kubitschek de Oliveira, KM-02, Bairro Zerão, CEP 68902-280 Macapá, AP.
    7. 7Laboratório de Tecnologia Farmacêutica, Departamento e Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, UFF Rua: Mario Viana, 523, CEP: 24241-000, Santa Rosa, Niterói.
    8. 8Laboratório de Tecnologia de Produtos Naturais, LTPN, Departamento e Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, UFF Rua: Mario Viana, 523, CEP: 24241-000, Santa Rosa, Niterói, RJ, Brazil.

    CORRESPONDENCE

    Caio Pinho Fernandes

    Laboratório de Nanobiotecnologia Fitofarmacêutica, Colegiado de Farmácia, Universidade Federal do Amapá, Campus Universitário Marco Zero do Equador, Rodovia Juscelino Kubitschek de Oliveira, KM, 02 Bairro Zerão, CEP: 68902-280, Macapá, AP.

    caiofernandes@unifap.br

    Volume 11, Issue 44s3 · pp. 533–7 · PUBLISHED 2015 · DOI: 10.4103/0973-1296.172957

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Manilkara subsericea (Sapotaceae) is a species widely spread in the sandbanks of Restinga de Jurubatiba National Park (Rio de Janeiro, Brazil). It is commonly known as “maçaranduba”, “maçarandubinha” and “guracica,” being used in this locality as food, and timber. However, M. subsericea remains almost unexplored regarding its chemical constituents, including secondary metabolites from the leaves. Objective: Identify the chemical constituents from the leaves of M. subsericea. Materials and Methods: Leaves were macerated with ethanol (96% v/v), and dried crude ethanolic extract was sequentially washed with the organic solvents in order to obtain an ethyl acetate fraction. Substances from this fraction were identified by different techniques, such as negative-ion electrospray ionization Fourier and 1H and 13C nuclear magnetic resonance (NMR). Fresh leaves from M. subsericea were also submitted to hydrodistillation in order to obtain volatile substances, which were identified by gas chromatograph coupled to mass spectrometer. Results: NMR1H and 13C spectra allowed for the identification of the compounds myricetin, quercetin, and kaempferol from the ethyl acetate fraction. The negative-ion electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry mass spectrum also revealed the presence in this fraction of a polyhydroxytriterpene acid (pomolic acid), and some flavonoids, such as quercitrin, and myricitrin. In all 34 volatile compounds were identified by gas chromatography-mass spectrometry, including monoterpenes, sesquiterpenes, and long chain hydrocarbons. Conclusion: This study describes the first reports concerning the phytochemical information about leaves from M. subsericea.

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      Almeida, F. B. D., Fernandes, C. P., Romao, W., Vanini, G., Costa, H. B., França, H. S., Santos, M. G., Carvalho, J. C. T., Falcão, D. Q., & Rocha, L. (2015). Secondary Metabolites from Leaves of Manilkara subsericea (Mart.) Dubard. Pharmacognosy Magazine, 11(44s3), 533–7. https://doi.org/10.4103/0973-1296.172957