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    Optimization of Ultrasound‑assisted Extraction of Phenolic Compounds from Myrcia amazonica DC. (Myrtaceae) Leaves

    Mariana Cristina de Morais Rodrigues1★, Leonardo Luiz Borges1, Frederico Severino Martins2, Rosa Helena V. Mourão1★ Corresponding author

    1. 1Edemilson Cardoso da Conceição Laboratory of PD&I of Bioproducts, School of Pharmacy, Federal University of Goiás, Jataí.
    2. 2Department of Pharmaceutical Sciences, Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto.
    3. 3Laboratory of Bioprospecting and experimental Biology, Department of Natural Resources of Amazônia, Federal University of Oeste do Pará, Santarém - PA, Brazil ORIGINAL ARTICLE Pharmacogn. Mag. A multifaceted peer reviewed journal in the field of Pharmacognosy and Natural Products.

    CORRESPONDENCE

    Mariana Cristina de Morais Rodrigues

    Edemilson Cardoso da Conceição Laboratory of PD&I of Bioproducts, School of Pharmacy, Federal University of Goiás, Jataí.

    marianacmfarma@gmail.com

    Volume 12, Issue 45 · pp. 9–12 · PUBLISHED 2016 · DOI: 10.4103/0973-1296.175997

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Myrcia amazonica. DC is a species predominantly found in northern Brazil, and belongs to the Myrtaceae family, which possess various species used in folk medicine to treat gastrointestinal disorders, infectious diseases, and hemorrhagic conditions and are known for their essential oil contents. Materials and Methods: This study aimed applied the Box–Behnken design combined with response surface methodology to optimize ultrasound‑assisted extraction of total polyphenols, total tannins (TT), and total flavonoids (TF) from M. amazonica DC. Results: The results indicated that the best conditions to obtain highest yields of TT were in lower levels of alcohol degree (65%), time (15 min), and also solid: Liquid ratio (solid to liquid ratio; 20 mg: 5 mL). The TF could be extracted with high amounts with higher extraction times (45 min), lower values of solid: Liquid ratio (20 mg: mL), and intermediate alcohol degree level. Conclusion: The exploitation of the natural plant resources present very important impact for the economic development, and also the valorization of great Brazilian biodiversity. The knowledge obtained from this work should be useful to further exploit and apply this raw material.

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      Rodrigues, M. C. D. M., Borges, L. L., Martins, F. S., & Mourão, R. H. V. (2016). Optimization of Ultrasound‑assisted Extraction of Phenolic Compounds from Myrcia amazonica DC. (Myrtaceae) Leaves. Pharmacognosy Magazine, 12(45), 9–12. https://doi.org/10.4103/0973-1296.175997