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    Potential Antidepressant Constituents of Nigella sativa Seeds

    Ehab S. Elkhayat1★, Mohammad S. Alorainy2, Ibrahim M. El-Ashmawy3,5, Shawkat Fat’hi3,4★ Corresponding author

    1. 1Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.
    2. 2Department of Pharmacology, College of Medicine, Qassim University, Saudi Arabia.
    3. 3Department of Pharmacology, Faculty of Veterinary Medicine, Alexandria University, Egypt.
    4. 4Department of Veterinary Medicine, College of Agricultural and Veterinary Medicine, Qassim University, Buraidah, AL-Qassim, Saudi Arabia.
    5. 5Department of Food Hygiene, Faculty of Veterinary Medicine, Assiut University, Assiut 71526, Egypt.

    CORRESPONDENCE

    Ehab S. Elkhayat

    Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.

    khayat71@yahoo.com

    Volume 12, Issue 45s · pp. S27–S31 · PUBLISHED 2016 · DOI: 10.4103/0973-1296.176118

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Nigella sativa Linn. is well known seed in the Middle East, Asia, and the Far East as a natural remedy for many ailments and as a flavoring agent proclaimed medicinal usage dating back to the ancient Egyptians, Greeks, and Romans. An authentic saying of the Prophet Muhammad (Peace Be Upon Him) about black seed is also quoted in Al-Bukhari. Objective: This study was carried out to evaluate the antidepressant effect and isolate the potential antidepressant constituents of the polar extract of N. sativa seeds. Materials and Methods: The antidepressant effect was evaluated through the immobility duration in tail suspension and forced swim tests (FSTs). Albino mice were orally treated with N. sativa polar extract and its RP-18 column chromatography fractions (50 and 100 mg/kg,). Results: The polar extract and two of its sub-fractions were significantly able to decrease the immobility time of mice when subjected to both tail suspension and FSTs, the effects are comparable to standard drug (Sertraline, 5 mg/kg). However, these treatments did not affect the number of crossings and rearing in the open field test. Phytochemical investigation of the two active fractions led to the isolation of quercetin-3-O-α-L-rhamnopyranoside 1, quercetin-7-O-β-D-gluco- pyranoside 2, tauroside E 3, and sapindoside B as the potential antidepressant constituents.

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      Elkhayat, E. S., Alorainy, M. S., El-Ashmawy, I. M., & Fat’hi, S. (2016). Potential Antidepressant Constituents of Nigella sativa Seeds. Pharmacognosy Magazine, 12(45s), S27–S31. https://doi.org/10.4103/0973-1296.176118