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    Bioactivities of Ethanolic Extract and its Fractions of Cistus laurifolius L. (Cistaceae) and Salvia wiedemannii Boiss. (Lamiaceae) Species

    Osman Ustun1, Berrin-Ozcelik Berrin-Ozcelik1★, Turhan Baykal1★ Corresponding author

    1. 1Departments of Pharmacognosy and Pharmaceutical Microbiology, Gazi University, 06330 Ankara, Turkey.

    CORRESPONDENCE

    Berrin-Ozcelik Berrin-Ozcelik

    Berrin-Ozcelik,Departments of Pharmacognosy and Pharmaceutical Microbiology, Gazi University, 06330 Ankara, Turkey.

    microberr@yahoo.com

    Volume 12, Issue 45s · pp. S82–S5 · PUBLISHED 2016 · DOI: 10.4103/0973-1296.176125

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Cistus laurifolius L. (Cistaceae) and Salvia wiedemannii Boiss. (Lamiaceae) have been used for treatment of some illnesses in Turkish folk medicine. In the present study, the ethanolic extract and its fractions obtained using re-extraction by hexane (Hx), chloroform (CHCl3), butanol, and remaining-water (r-H2O) of C. laurifolius were screened for their in vitro bioactivities. Materials and Methods: Activities were determined against both standard and the isolated strains of Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, as well as yeasts such as Candida albicans and Candida parapsilosis by microdilution method. Also, antiviral activity of C. laurifolius and S. wiedemannii extracts were tested on herpes simplex virus-1 (HSV-1) and parainfluenza-3 (PI-3) using Madin-Darby bovine kidney and vero cell lines. Results: Tested extracts of C. laurifolius (minimum inhibitory concentration 32 μg/mL) exerted a strong antimicrobial activity against Gram-negative bacteria of E. coli, P. mirabilis, K. pneumoniae, and A. baumannii. Conclusion: The Hx extract of C. laurifolius (cytopathogenic effect of 32–8 μg/mL) had antiviral activity on PI-3. Also, the r-H2O, CHCl3, and ethanol extracts (16–<0.25 μg/mL) of S. wiedemannii had significant antiviral activity on HSV-1, same as control.

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      Ustun, O., Berrin-Ozcelik, B., & Baykal, T. (2016). Bioactivities of Ethanolic Extract and its Fractions of Cistus laurifolius L. (Cistaceae) and Salvia wiedemannii Boiss. (Lamiaceae) Species. Pharmacognosy Magazine, 12(45s), S82–S5. https://doi.org/10.4103/0973-1296.176125