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    S201 Intrathecal Injection of Resveratrol Attenuates Burn Injury Pain by Activating Spinal Sirtuin 1

    Wei Cheng1★, Jin‑Feng Wang1★, Cong‑Xian Yang1★, Liang Wu3, Qin Yin3, He Liu2, Zhi‑Jian Fu2★★ Corresponding author

    1. 1Department of Pain Management, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong 250000.
    2. 2Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical College, Jiangsu Province Key Laboratory of Anesthesiology and Center for Pain Research and Treatment.
    3. 3Department of Anesthesiology, Xuzhou Central Hospital, Jiangsu 221002, PR China Pharmacogn. Mag. A multifaceted peer reviewed journal in the field of Pharmacognosy and Natural Products.

    CORRESPONDENCE

    Wei Cheng

    Department of Pain Management, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong 250000.

    zhijian_fu@126.com

    Received: 29-08-2015; Revised: 16-10-2015.

    Volume 12, Issue 46s · pp. S201–S205 · PUBLISHED 11 May 2016 · DOI: 10.4103/0973-1296.182167

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: The present study sought to detect spinal sirtuin 1 (SIRT1) and acetylation of histone H3 (Ac‑H3) expression in rats with burn injury pain (BIP model). Procedures and Results: A BIP model was first established. BIP rats showed lower paw withdrawal threshold (PWT) from day 1, which persisted for 21 days following the burn injury. Spinal SIRT1/Ac‑H3 expression increased following burn injury. The intrathecal use of resveratrol increased PWT and SIRT1 expression but induced down‑regulation of Ac‑H3 expression. We first demonstrated that the inhibition of SIRT1 significantly induced mechanical allodynia in naïve rats. The preinjection of SIRT1 inhibitor partly antagonized the analgesic effects of resveratrol in BIP rats. Conclusion: Inhibition of SIRT1 produces pain facilitation in the naïve rats. The expression of spinal SIRT1 increased after burn injury in the BIP model. The activation of spinal SIRT1 might mediate the resveratrol‑induced analgesic effects.

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      Cheng, W., Wang, J., Yang, C., Wu, L., Yin, Q., Liu, H., & Fu, Z. (2016). S201 Intrathecal Injection of Resveratrol Attenuates Burn Injury Pain by Activating Spinal Sirtuin 1. Pharmacognosy Magazine, 12(46s), S201–S205. https://doi.org/10.4103/0973-1296.182167