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    Article

    Phytochemicals from Tradescantia albiflora Kunth Extracts Reduce Serum Uric Acid Levels in Oxonate-induced Rats

    Wen-Ling Wang2,3, Shi-Yuan Sheu4,5,6, Wen-Dar Huang7, Ya-Ling Chuang8, Han-Chun Tseng9, Tzann-Shun Hwang10, Yuan-Tsung Fu11,12, Yueh-Hsiung Kuo13,14★, Chun-Hsu Yao2,15,16★, Tzong-Fu Kuo8,17★★ Corresponding author

    1. 1School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taiwan.
    2. 2Department of Chinese Internal Medicine, China Medical University Hospital, Taiwan.
    3. 3School of Medicine, Chung Shan Medical University, Taiwan.
    4. 4Department of Integrated Chinese and Western Medicine, Chung Shan Medical University Hospital, Departments of, Taiwan.
    5. 5Occupational Therapy, Taiwan.
    6. 6Agronomy and, Taiwan.
    7. 7School of Veterinary Medicine, National Taiwan University, Taiwan.
    8. 8Chemistry, National Taiwan University, Taiwan.
    9. 9Graduate Institute of Biotechnology, Chinese Culture University, Taipei, Taiwan.
    10. 10Department of Chinese Medicine, Buddhist Tzu Chi General Hospital, Taichung Branch, Departments of, Taiwan.
    11. 11School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Departments of, Taiwan.
    12. 12Chinese Pharmaceutical Sciences and Chinese Medicine Resources and, Taiwan.
    13. 13Biotechnology, Taiwan.
    14. 14Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.
    15. 15Biomedical Informatics and, Taiwan.
    16. 16Post-Baccalaureate Veterinary Medicine, Asia University, Taiwan.

    CORRESPONDENCE

    Yueh-Hsiung Kuo

    Biotechnology, Taiwan.

    Kuoyh@mail.cmu.edu.tw

    Received: 11-10-2015; Revised: 10-12-2015.

    Volume 12, Issue 46s · pp. S223–S227 · PUBLISHED 11 May 2016 · DOI: 10.4103/0973-1296.182171

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Tradescantia albiflora (TA) Kunth (Commelinaceae) has been used for treating gout and hyperuricemia as folklore remedies in Taiwan. Therefore, it is worthwhile to study the effect of TA extracts on lowering uric acid activity. The hypouricemic effects of TA extracts on potassium oxonate (PO)‑induced acute hyperuricemia were investigated for the first time. Materials and Methods: All treatments at the same volume (1 ml) were orally administered to the abdominal cavity of PO‑induced hyperuricemic rats. One milliliter of TA extract in n-hexane (HE), ethyl acetate (EA), n-butanol (BuOH), and water fractions has 0.28, 0.21, 0.28, and 1.03 mg TA, respectively; and the plasma uric acid (PUA) level was measured for a consecutive 4 h after administration. Results: All four fractions’ extracts derived from TA were observed to significantly reduce PUA compared with the PO group. The EA‑soluble fraction (TA‑EA) exhibited the best xanthine oxidase (XO) inhibitory activity. Following column chromatography, 12 phytochemicals were isolated and identified from the EA fraction. The IC50 values of isolated phytochemicals indicated that bracteanolide A (AR11) showed the remarkable XO inhibitory effect (IC50 value of 76.4 µg/ml). These findings showed that the in vivo hypouricemic effect in hyperuricemic rats was consistent with in vitro XO inhibitory activity, indicating that TA extracts and derived phytochemicals could be potential candidates as hypouricemic agents.

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      Wang, W., Sheu, S., Huang, W., Chuang, Y., Tseng, H., Hwang, T., Fu, Y., Kuo, Y., Yao, C., & Kuo, T. (2016). Phytochemicals from Tradescantia albiflora Kunth Extracts Reduce Serum Uric Acid Levels in Oxonate-induced Rats. Pharmacognosy Magazine, 12(46s), S223–S227. https://doi.org/10.4103/0973-1296.182171