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    Antifatigue Effects of Ethanol Extracts and Polysaccharides Isolated from Abelmoschus esculentus

    Yu-Xian Li1★, Zhong-Han Yang2, Yin Lin3, Wei Han4, Shan-Shan Jia4, Ke Yuan4★ Corresponding author

    1. 1College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450008, P. R. China, China.
    2. 2College of Chemical Industry and Environment Engineering, Jiaozuo University, Jiaozuo 454000, P. R. China, China.
    3. 3School of Pharmacy, East China University of Science and Technology, Shanghai 200237, P. R. China, China.
    4. 4Zhejiang Agriculture and Forestry University, Lin’an 311300, P. R. China, China.

    CORRESPONDENCE

    Yu-Xian Li

    College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450008, P. R. China, China.

    liyuxian1963@126.com

    Received: 24-05-2015; Revised: 27-06-2015; Accepted: 27-06-2015.

    Volume 12, Issue 47 · pp. 219–24 · PUBLISHED 14 July 2016 · DOI: 10.4103/0973-1296.186341

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The aim of this study is to determine the antifatigue active fraction from Abelmoschus esculentus. The in vivo antifatigue effects of ethanol extracts and polysaccharides from A. esculentus fruit have been determined. The polysaccharides of A. esculentus were determined as the best effective fractions of antifatigue effects. Materials and Methods: About 360 Kunming male mice were randomly divided into nine subgroups: normal control subgroup, model subgroup, positive subgroup and the ethanol extracts of A. esculentus with high dose (3.2 g/kg) subgroup, medium dose (1.6 g/kg) subgroup and low dose (0.8 g/kg) subgroup, the polysaccharides of high dose (3.2 g/kg) subgroup, medium dose (1.6 g/kg) subgroup, and the low dose (0.8 g/kg) subgroup. The antifatigue effects of ethanol extracts and polysaccharides form A. esculentus were measured by comparing body weight, food intake, swimming time, liver glycogen, serum urea, blood lactic acid as well as visceral parameter in mice. Results: Compared with the model subgroup, other subgroups significantly prolonged swimming time, and high dose polysaccharides administration was the most effective (P < 0.01). High dose polysaccharides significantly increased liver glycogen, serum lactic acid, and serum urea (P < 0.01) in mice. In contrast with model group, the high dose polysaccharides administration could also significantly elevated the parameters of testicles and epididymis (P < 0.01). The study established that the ethanol extracts and polysaccharides of A. esculentus both have antifatigue effects. Conclusions: The results demonstrated that both the ethanol extracts and polysaccharides of A. esculentus have antifatigue effects. The high dosage polysaccharides have significant antifatigue properties. The results will provide the basis for further development and utilization of this plant.

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      Li, Y., Yang, Z., Lin, Y., Han, W., Jia, S., & Yuan, K. (2016). Antifatigue Effects of Ethanol Extracts and Polysaccharides Isolated from Abelmoschus esculentus. Pharmacognosy Magazine, 12(47), 219–24. https://doi.org/10.4103/0973-1296.186341