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    Composition of The Essential Oil From Danggui-zhiqiao Herb-Pair and Its Analgesic Activity and Effect on Hemorheology in Rats With Blood Stasis Syndrome

    Yuanqing Wang1, Jianye Yan2, Shunxiang Li3★, Wei Wang4, Xiong Cai5, Dan Huang5, Limin Gong5, Xin Li5★ Corresponding author

    1. 1Department of biotechnology, Lab of Biotechnology and Engineering, School of Life Science and Technology, Central South University of Forestry and Technology, Changsha, China.
    2. 2Department of Chemistry, Hunan Province Engineering Research Center of Bioactive Substance Discovery of Traditional Chinese Medicine, Changsha, China.
    3. 3Department of Chemistry, TCM and Ethnomedicine Innovation and Development Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
    4. 4Department of diagnosis, Diagnostic Institute of Traditional Chinese Medicine, Changsha, China.
    5. 5Department of Chemistry, Province & State Key Laboratory Breeding Base of Chinese medicine powder and Medicine Innovation in Hunan, Hunan University of Chinese Medicine, Changsha, China.

    CORRESPONDENCE

    Shunxiang Li

    Department of Chemistry, TCM and Ethnomedicine Innovation and Development Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.

    lishunxiang@hotmail.com

    Received: 26-05-2015; Revised: 27-06-2015; Accepted: 27-06-2016.

    Volume 12, Issue 48 · pp. 271–5 · PUBLISHED 13 October 2016 · DOI: 10.4103/0973-1296.192195

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Angelica sinensis and Aurantii fructu used in a pair, named Danggui-Zhiqiao herb-pair (DZHP), which was rich in essential oil and has been adopted to promote blood circulation, dispel blood stasis, and relieve pain in traditional Chinese medicine (TCM) Objective: To analyze the composition and pharmacological effects of essential oil from DZHP Materials and Methods: The composition of the essential oil from DZHP was analyzed by gas chromatography/mass spectrometry (GC/MS). Its analgesic activity was evaluated by acetic acid-induced writhing test and hot plate test. The hemorheology test was carried out to evaluate the effect on hemorheology in rats with blood stasis syndrome Results: Twenty-eight components were identified and the main components were α-pinene (3.07%), β-pinene (2.0%), β-myrcene (3.71%), D-limonene (49.28%), γ-terpinen (9.53%), α-terpinolene (1.80%), α-terpineol (2.02%), β-bisabolene (1.13%), butylidenephthalide (1.43%), and Z-ligustilide (16.08%). The pharmacology test showed that the essential oil significantly inhibited the number of writhes induced by acetic acid with inhibition rate of 44.64% and significantly increased hot-plate latency compared with control group from 30 to 90 min after oral administration of drugs in mice. It could significantly decrease plasma viscosity, whole blood relative index at high and low shear rate, whole blood reduced viscosity at high and low shear rate, and erythrocyte rigidity index in hemorheology test Conclusion: The composition of the essential oil of DZHP was determined successfully and it had analgesic and promoting blood circulation activities.

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      Wang, Y., Yan, J., Li, S., Wang, W., Cai, X., Huang, D., Gong, L., & Li, X. (2016). Composition of The Essential Oil From Danggui-zhiqiao Herb-Pair and Its Analgesic Activity and Effect on Hemorheology in Rats With Blood Stasis Syndrome. Pharmacognosy Magazine, 12(48), 271–5. https://doi.org/10.4103/0973-1296.192195