Chemical Components from Aloe and their Inhibition of Indoleamine 2, 3-dioxygenase
Ya Nan Sun1, Lin Ying Li1, Wei Li2, Jong Seong Kang1, Inkyu Hwang1, Young Ho Kim1★★ Corresponding author
- 1College of Pharmacy, Chungnam National University, Daejeon, Korea.
- 2School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, Korea.
CORRESPONDENCE
Young Ho Kim
College of Pharmacy, Chungnam National University, Daejeon, Korea.
Received: 03-09-2016; Revised: 11-07-2016; Accepted: 07-11-2016.
Volume 13, Issue 49 · pp. 58–63 · PUBLISHED 1 June 2017 · DOI: 10.4103/0973-1296.197633
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ABSTRACT
Background: In Korea, Aloe is routinely ingested as a traditional medicine or as a component of health beverages. Objective: To research the inhibition of indoleamine 2, 3-dioxygenase (IDO) activities of components from Aloe. Materials and Methods: the compounds were isolated by a combination of silica gel and YMC Rp-18 column chromatography, and their structures were identified by analysis of spectroscopic data (1D, 2D-NMR, and MS). All of the isolated compounds were examined for their ability to inhibit IDO, which actively suppresses immune functions by catalyzing the rate limiting reaction in the conversion of tryptophan to kynurenine. Results: In this phytochemical study, 18 known compounds were isolated from aqueous dissolved Aloe exudates. All of the isolated compounds were examined for their ability to inhibit IDO activities for a series of anthraquinone derivatives (1-7) isolated from the Aloe extract; the IC50 values of these compounds ranged from 39.41 to 53.93 µM. Enzyme kinetic studies of their modes of inhibition indicated that all of the compounds were uncompetitive inhibitors. Conclusion: The aqueous dissolved Aloe exudate can be used as a source of novel natural IDO inhibitors and merit testing as therapeutic agents in the treatments of cancer and immunopathologic diseases, such as autoimmune, inflammatory, and allergic disorders.
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Sun, Y. N., Li, L. Y., Li, W., Kang, J. S., Hwang, I., & Kim, Y. H. (2017). Chemical Components from Aloe and their Inhibition of Indoleamine 2, 3-dioxygenase. Pharmacognosy Magazine, 13(49), 58–63. https://doi.org/10.4103/0973-1296.197633