Caffeic Acid Phenethyl Ester (CAPE) Prevents Development of STZ-ICV Induced dementia in Rats
Manish Kumar1, Devinder Kaur1, Nitin Bansal1★★ Corresponding author
- 1Department of Pharmacology, ASBASJSM College of Pharmacy, Bela, Ropar, India.
CORRESPONDENCE
Nitin Bansal
Department of Pharmacology, ASBASJSM College of Pharmacy, Bela, Ropar, India.
Received: 25-06-2016; Revised: 08-11-2016; Accepted: 08-11-2016.
Volume 13, Issue 49s · pp. 10–5 · PUBLISHED 7 April 2017 · DOI: 10.4103/0973-1296.203974
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ABSTRACT
Background: Chronic oxidative stress and inflammation severely affect the normal physiology of neurons and lead to neurodegenerative disorders such as Alzheimer’s disease (AD). Polyphenols proved a boon in the prevention of dementia due to their antioxidant and neuroprotective potential. Caffeic acid phenethyl ester (CAPE) is a natural polyphenolic compound attributed with antioxidant, immunomodulatory, and neuroprotective properties. Objective: The present study investigates the effect of CAPE on experimental dementia in rats. Methods: Intracerebroventricle (ICV) injection of streptozotocin (STZ; 3 mg/kg) was given to Wistar rats (200 g, either sex) on days 1 and 3 to induce dementia of AD type. CAPE (3 and 6 mg/kg, i.p.) was administered to separate groups of rats for 28 successive days daily. Morris water maze and elevated plus maze served as exteroceptive behavioral models to measure the memory of the rats. Results: The present study illustrated that CAPE treatment for 28 consecutive days arrested the development of cognitive deficits in STZ-ICV-treated rats, that is, a significant (P < 0.05) reduction in the mean escape latency during acquisition trial and increased (P < 0.05) time spent in target quadrant during retrieval trial in Morris water maze test and reduction (P < 0.05) in transfer latency in elevated plus maze test. Furthermore, both the doses of CAPE when administered to rats that were previously treated with STZ-ICV prevented the rise of brain thiobarbituric acid reactive substance as well as TNF-α and simultaneously enhanced the GSH content. Conclusion: CAPE administration ameliorated STZ-ICV-induced dementia through the attenuation of oxidative stress and inflammation.
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Kumar, M., Kaur, D., & Bansal, N. (2017). Caffeic Acid Phenethyl Ester (CAPE) Prevents Development of STZ-ICV Induced dementia in Rats. Pharmacognosy Magazine, 13(49s), 10–5. https://doi.org/10.4103/0973-1296.203974