Volume 13, Issue 49s

Potential Lipid-Lowering Effects of Eleusine indica (L) Gaertn. Extract on High-Fat-Diet-Induced Hyperlipidemic Rats

Siew Ling Ong, Koteswara Rao Nalamolu, How Yee Lai

pp. 1–9 · DOI: 10.4103/0973-1296.203986 · Published 7 April 2017

Background: To date, anti-obesity agents based on natural products are tested for their potential using lipase inhibition assay through the interference of hydrolysis of fat by lipase resulting in reduced fat absorption …

Caffeic Acid Phenethyl Ester (CAPE) Prevents Development of STZ-ICV Induced dementia in Rats

Manish Kumar, Devinder Kaur, Nitin Bansal

pp. 10–5 · DOI: 10.4103/0973-1296.203974 · Published 7 April 2017

Background: Chronic oxidative stress and inflammation severely affect the normal physiology of neurons and lead to neurodegenerative disorders such as Alzheimer’s disease (AD). Polyphenols proved a boon in the prevention…

In vitro Anti-Proliferative Effect of Tephrosia purpurea on Human Hepatocellular Carcinoma Cells

Ramamoorthy Padmapriya, Loganathan Gayathri, Larance Ronsard, Mohammad A. Akbarsha, Ramasamy Raveendran

pp. 16–21 · DOI: 10.4103/0973-1296.203981 · Published 7 April 2017

Background: Tephrosia purpurea is an Indian herb used in traditional medicine to treat various diseases such as jaundice, asthma, liver and urinary disorders. However, the anti-cancer potential of T. purpurea on hepatoce…

Fatty Acid Profiling and In Vitro Antihyperglycemic Effect of Leucas cephalotes (Roth) Spreng via Carbohydrate Hydrolyzing Enzyme Inhibition

Anjali Verma, Anil Kumar, Dalip Kumar Upreti, Veena Pande, Mahesh Pal

pp. 22–5 · DOI: 10.4103/0973-1296.203993 · Published 7 April 2017

Background: Leucas cephalotes has been used by many tribes to treat variety of diseases and known to have many essential secondary metabolites. To the best of our knowledge, it is the first comparative analysis of total …

Influence of Capsaicin on Inflammatory Cytokines Induced by Lipopolysaccharide in Myoblast Cells Under In vitro Environment

Ke Shang, Touseef Amna, Musarat Amina, Nawal M. Al-Musayeib, Salem S. Al-Deyab, Inho Hwang

pp. 26–32 · DOI: 10.4103/0973-1296.203984 · Published 7 April 2017

Background: Cellular damage initiated by reactive oxygen species (ROS) is the main cause of numerous severe diseases and therefore for this reason, the natural antioxidants have note worthy significance in human health. …

Cytotoxic Metabolites from Callyspongia siphonella Display Antiproliferative Activity by Inducing Apoptosis in HCT-116 Cells

Tariq R.A. Sobahi, Seif-Eldin N. Ayyad, Ahmed Abdel-Lateff, Mardi M. Algandaby, Hajer S. Alorfi, Ashraf B. Abdel-Naim

pp. 37–40 · DOI: 10.4103/0973-1296.203970 · Published 7 April 2017

Objectives: To evaluate the antiproliferative effect of the isolated metabolites from Callyspongia siphonella. Methods: Different chromatographic methods have been done on the organic extract of the marine sponge aiming …

Antiproliferative and Proapoptotic Activities of Marine Sponge Hyrtios erectus Extract on Breast Carcinoma Cell Line (MCF-7)

Ramachandran Muthiyan, Balwin Nambikkairaj, Nilkamal Mahanta, Titus Immanuel, Rahul Shubhra Mandal, Kubendiran Kumaran, Arun Kumar De

pp. 41–7 · DOI: 10.4103/0973-1296.203983 · Published 7 April 2017

Background: Marine sponge is a rich natural resource of many pharmacologically important compounds. Objective: Marine sponge Hyrtios erectus, collected from North Bay, South Andaman Sea, India, was screened for potential…

Anti-plasmodial and Chloroquine Resistance Suppressive Effects of Embelin

O.I. O.I., R. Majid, M.S. M.S., M.N. M.N., K. Al-Zihiry, Sattar Rahi, R. R.

pp. 48–55 · DOI: 10.4103/0973-1296.203982 · Published 7 April 2017

Background: Emergence of chloroquine (CQ) resistance among different strains of Plasmodium falciparum is the worst catastrophe that has ever perplexed the dedicated efforts to eradicate malaria. This urged the scientists…

Exploratory Studies of (-)-Epicatechin, a Bioactive Compound of Phyllanthus niruri, on the Antioxidant Enzymes and Oxidative Stress Markers in D-galactosamine-induced Hepatitis in Rats: A Study with Reference to Clinical Prospective

Bhasha Shanmugam, Kondeti Ramudu Shanmugam, Sahukari Ravi, Ganjikunta Venkata Subbaiah, Chilakala Ramakrishana, Korivi Mallikarjuna, Kesireddy Sathyavelu Reddy

pp. 56–62 · DOI: 10.4103/0973-1296.203973 · Published 7 April 2017

Background: Hepatitis is a health problem affecting millions of people worldwide and it is the major risk factor for liver cirrhosis. In India, many plants are used to treat hepatitis. But little is known about the effec…

Ginger Treatment Ameliorates Alcohol-induced Myocardial Damage by Suppression of Hyperlipidemia and Cardiac Biomarkers in Rats

Ganjikunta Venkata Subbaiah, Korivi Mallikarjuna, Bhasha Shanmugam, Sahukari Ravi, Patan Usnan Taj, Kesireddy Sathyavelu Reddy

pp. 69–75 · DOI: 10.4103/0973-1296.203891 · Published 7 April 2017

Background: Alcohol-induced hyperlipidemia is positively correlated with cardiovascular diseases. Several herbal extracts have been reported to protect the cardiac injury and suppress the hyperlipidemia. However, the eff…

Anti-hepatocarcinogenic and Anti-oxidant Effects of Mangrove Plant Scyphiphora hydrophyllacea

Sameera R. Samarakoon, Chanthirika Shanmuganathan, Meran K. Ediriweera, Poorna Piyathilaka, Kamani H. Tennekoon, Ira Thabrew, Prasanna Galhena, E Dilip Silva

pp. 76–83 · DOI: 10.4103/0973-1296.203989 · Published 7 April 2017

Context:Scyphiphora hydrophyllacea is a shrub mangrove plant of the family Rubiaceae and not yet been studied for anti-hepatocarcinogenic effects. Objectives: We investigated possible in vitro anti-hepatocarcinogenic and…

Medicinal Plants Used by Traditional Healers in Jordan, the Tafila Region

Abeer Abdelhalim, Talal Aburjai, Jane Hanrahan, Heba Abdel-Halim

pp. 95–101 · DOI: 10.4103/0973-1296.203975 · Published 7 April 2017

Background: The reporting of the medicinal plants and their traditional uses is important in order to prevent this knowledge from being lost. The aims of this study were to collect information concerning the traditional …

The Inhibition of Hepatic and Renal Glucuronidation of p-Nitrophenol and 4-Methylumbelliferone by Oil Palm Empty Fruit Bunch Lignin and Its Main Oxidation Compounds

Norliyana Mohamad Salleh, Sabariah Ismail, Mohamad Nasir Mohamad Ibrahim

pp. 102–114 · DOI: 10.4103/0973-1296.203990 · Published 7 April 2017

Background: In order to develop oil palm empty fruit bunch (EFB) lignin as a nutraceutical and health supplement, the investigation of its potential in interacting with other drugs via inhibition of drug-metabolizing enz…

Cucurbitane-Type Triterpenoids from the Blood Glucose-Lowering Extracts of Coccinia indica and Momordica balsamina Fruits

Ujjwal Kaushik, Vidhu Aeri, Mir Showkat R., Mohammad Ali

pp. 115–121 · DOI: 10.4103/0973-1296.203991 · Published 7 April 2017

Context: Few vegetables that are commonly consumed in India as part of diet have been claimed for their antidiabetic potential. Objective: The present study was aimed at evaluating preventive effects of cucurbit vegetabl…

In-vitro Wound Healing Effect of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor from Plant

Sandeep Karna

pp. 122–6 · DOI: 10.4103/0973-1296.203971 · Published 7 April 2017

Background: Prostaglandins (PGs) have short existence in vivo because they are rapidly metabolized by NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) to 15-ketoprostaglandins. Inhibition of 15-PGDH causes …

Flavonoids from whole Plant of Euphorbia hirta and their Evaluation against Experimentally induced Gastroesophageal Reflux Disease in Rats

Shyam Sundar Gupta, Lubna Azmi, P. K. Mohapatra, Ch. V. Rao

pp. 127–34 · DOI: 10.4103/0973-1296.203987 · Published 7 April 2017

Background: Euphorbia hirta possesses antibacterial, anti-inflammatory, galactogenic, antidiarrheal, antioxidant, hypoglycemic, antiasthmatic, antiamebic, antifungal, and antimalarial activities. Objective: The overall o…

Prenatal Developmental Toxicity Study of Glycosides-based Standardized Fenugreek Seed Extract in Rats

Pallavi O. Deshpande, Vishwaraman Mohan, Mukul P. Pore, Shailesh Gumaste, Prasad A. Thakurdesai

pp. 135–41 · DOI: 10.4103/0973-1296.203978 · Published 7 April 2017

Context: Glycoside-based standardized fenugreek seed extract (SFSE-G) demonstrated promising efficacy in animal models of immune-inflammatory conditions. Aim: The present study was aimed at embryo-fetal development toxic…

Preparation of Ginseng Extract with Enhanced Levels of Ginsenosides Rg1 and Rb1 Using High Hydrostatic Pressure and Polysaccharide Hydrolases

Sasikumar Arunachalam Palaniyandi, Joo-Won Suh, Seung Hwan Yang

pp. 142–7 · DOI: 10.4103/0973-1296.203992 · Published 7 April 2017

Background: Ginsenosides are the principal components responsible for the pharmacological activities of ginseng. Ginsenosides Rg1 and Rb1 are the major compounds recognized as marker substances for quality control of gin…

Effect of Shankhpushpi on Alcohol Addiction in Mice

Mahi Heba, Sana Faraz, Sugato Banerjee

pp. 148–53 · DOI: 10.4103/0973-1296.203976 · Published 7 April 2017

Alcohol addiction is a worldwide problem. It has mainly two components: dependence and withdrawal. Characteristic properties of most anti-addictive compounds include anti-anxiety, anticonvulsant, antidepressant, and noot…

Effect of Naringenin (A naturally occurring flavanone) Against Pilocarpine-induced Status Epilepticus and Oxidative Stress in Mice

Sheeba Shakeel, Muneeb U. Rehman, Nahida Tabassum, Umar Amin, Manzoor ur Rahman Mir

pp. 154–60 · DOI: 10.4103/0973-1296.203977 · Published 7 April 2017

Background: Epilepsy is a disorder of the central nervous system characterized by recurrent seizures. It is a very common disease in which approximately 30% of patients do not respond favourably to treatment with anticon…

Biosynthesis, Characterization, and Biological Activities of Iron Nanoparticles using Sesamum indicum Seeds Extract

Farah Bano, Muhammad Baber, Amjad Ali, Ziaullah Shah, Syed Aun Muhammad

pp. 33–36 · DOI: 10.4103/0973-1296.203985 · Published 7 April 2017

Background: Iron nanoparticles (FeNPs) have got many biomedical and health applications because of biocompatible and nontoxic nature to humans. Objective: To synthesize the FeNPs using natural sources. Materials and Meth…

In vitro Toxicity and Genotoxic Activity of Aqueous Leaf Extracts From Four Varieties of Olea europea (L)

Luc Verschaeve, Hayet Edziri, Roel Anthonissen, Dalenda Boujnah, Fethia Skhiri, Hechmi Chehab, Mahjoub Aouni, Maha Mastouri

pp. 63–68 · DOI: 10.4103/0973-1296.203980 · Published 7 April 2017

Aim: Despite its therapeutic value almost nothing is known about potential adverse health effects of Olea europea L. We therefore investigated the in vitro toxicity and genotoxicity of leaf extracts of this plant. Materi…

Simultaneous Determination of Multiple Ginsenosides in Panax ginseng Herbal Medicines with One Single Reference Standard

Chunwei Wu, Qingxiao Guan, Shumei Wang, Yueying Rong

pp. 84–89 · DOI: 10.4103/pm.pm_274_16 · Published 7 April 2017

Background: Root of Panax ginseng C. A. Mey (Renseng in Chinese) is a famous Traditional Chinese Medicine. Ginsenosides are the major bioactive components. However, the shortage and high cost of some ginsenoside referenc…

Nutraceutical Value of Pure Curcumin

Biji T Kurien, Hiroyuki Matsumoto, R Hal Scofield

pp. 161–3 · DOI: 10.4103/0973-1296.203988 · Published 2017