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    Expression of Hepatic Cytochrome P450s in Rats Administered with Guibi-tang, a Traditional Herbal Formula

    Seong Eun Jin2, Hyekyung Ha2, Chang‑Seob Seo2, Hyeun‑Kyoo Shin2, Soo‑Jin Jeong3,4★★ Corresponding author

    1. 1K‑herb Research Center, Korea Institute of Oriental Medicine.
    2. 2KM Convergence Research Division, Korea Institute of Oriental Medicine.
    3. 3Korean Medicine Life Science, University of Science and Technology, Daejeon, Republic of Korea.

    CORRESPONDENCE

    Soo‑Jin Jeong

    Korean Medicine Life Science, University of Science and Technology, Daejeon, Republic of Korea.

    sjijeong@kiom.re.kr

    Received: 17-03-2017; Revised: 13-06-2017.

    Volume 13, Issue 52s · pp. S822–S827 · PUBLISHED 31 January 2018 · DOI: 10.4103/pm.pm_107_17

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: The aim of this study was to investigate the possible herb-drug interactions between the traditional herbal formula Guibi‑tang (GBT; Guipi‑tang, Kihi‑to) and conventional drugs. Materials and Methods: GBT was orally administered to either male or female Sprague Dawley (SD) rats once daily at doses of 1000, 2000, or 5000 mg/kg/day for 13 weeks. The messenger ribonucleic acid (mRNA) expression of drug‑metabolizing enzyme cytochrome P450 isozymes (cytochrome P450s; CYP1A1, 1A2, 2B1/2, 2C11, 2E1, 3A1, 3A2, and 4A1) was analyzed in hepatic tissues by reverse transcription‑polymerase chain reaction. Results: Repeated oral administration of GBT did not significantly influence the mRNA expression of hepatic CYP1A1, 1A2, 2B1/2, 2C11, 2E1, 3A1, 3A2, and 4A1 in male rats. By contrast, in female rats, the mRNA expression of hepatic CYP1A2 and 2B1/2 was significantly increased by repeated GBT treatment. Conclusion: Our findings indicate that caution is required in females when GBT is taken concomitantly with conventional drugs metabolized by CYP1A2 or 2B1/2. Our results provide information regarding the safety and effectiveness of GBT for clinical use.

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      Jin, S. E., Ha, H., Seo, C., Shin, H., & Jeong, S. (2018). Expression of Hepatic Cytochrome P450s in Rats Administered with Guibi-tang, a Traditional Herbal Formula. Pharmacognosy Magazine, 13(52s), S822–S827. https://doi.org/10.4103/pm.pm_107_17