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    Article

    Bioactivity‑Guided Isolation of Antioxidant Compounds from Pouzolzia zeylanica (L.) Benn

    Lujun Wang2★, Die Gao2, Qifeng Fu2, Kai Zhou3, Zhining Xia3★★ Corresponding author

    1. 1Department of Pharmaceutical Analysis, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
    2. 2Department of Pharmaceutical Analysis, School of Pharmacy, Chongqing University, Chongqing, China.

    CORRESPONDENCE

    Lujun Wang

    Department of Pharmaceutical Analysis, School of Pharmacy, Chongqing University, Chongqing, China.

    wlj@swmu.edu.cn

    Received: 08-06-2017; Revised: 05-07-2017.

    Volume 14, Issue 56 · pp. 444–450 · PUBLISHED 14 August 2018 · DOI: 10.4103/pm.pm_233_17

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: Pouzolzia zeylanica (L.) Benn. (Family: Urticaceae), which is widely distributed in China, is consumed as food and as a traditional herbal medicine for the treatment of numerous diseases. Objective: The aim of the present study was to explore the antioxidant compounds of P. zeylanica. Materials and Methods: A petroleum ether extract, an ethyl acetate extract (EAE), an n‑butanol extract, and the remaining part were separated by liquid–liquid extraction from a 90% aqueous ethanol extract and a water extract of P. zeylanica and were evaluated using two complementary antioxidant assays, namely 2,2‑diphenyl‑1‑picrylhydrazyl‑free radical scavenging and ferric‑reducing antioxidant power assays. Results: The EAE, which possessed the highest antioxidant activity, contained the highest total phenolic content (263.5 ± 4.8 mg/g) and total flavonoid content (388.3 ± 5.6 mg/g). In addition, three compounds with antioxidant activity, quercetin, kaempferol, and N‑[2‑(3‑hydroxy‑4‑methoxyphenyl)‑2‑hydroxyethyl]‑3‑(4‑methoxyphenyl) prop‑2‑enamide, were isolated from the EAE. Conclusions: These results demonstrate that the flavonoids and phenolic compounds from P. zeylanica could be used as natural antioxidants.

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      Wang, L., Gao, D., Fu, Q., Zhou, K., & Xia, Z. (2018). Bioactivity‑Guided Isolation of Antioxidant Compounds from Pouzolzia zeylanica (L.) Benn. Pharmacognosy Magazine, 14(56), 444–450. https://doi.org/10.4103/pm.pm_233_17