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    Article

    Peroxisome Proliferator‑Activated Receptor‑γ Agonistic Effect of Chrysanthemum indicum Capitulum and Its Active Ingredients

    Fuzi Zhang1, Anna Iwaki2, Kan’ichiro Ishiuchi1, Akinori Sugiyama3, Masahiro Ohsawa2, Toshiaki Makino1★★ Corresponding author

    1. 1Department of Pharmacognosy, School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467‑8603, Japan.
    2. 2Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467‑8603, Japan.
    3. 3Department of Health Chemistry, School of Pharmacy, Iwate Medical University, Morioka 020‑0023, Japan.

    CORRESPONDENCE

    Toshiaki Makino

    Department of Pharmacognosy, School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467‑8603, Japan.

    makino@phar.nagoya‑cu.ac.jp

    Received: 20-12-2017; Revised: 10-01-2018.

    Volume 14, Issue 56 · pp. 461–464 · PUBLISHED 14 August 2018 · DOI: 10.4103/pm.pm_607_17

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: The capitulum of Chrysanthemum indicum (Compositae) is the source of a crude drug used in Japanese traditional Kampo and traditional Chinese medicine. Previous research showed that C. indicum flowers promote adipocyte differentiation through the activation of peroxisome proliferator‑activated receptor (PPAR)‑γ that may be an important mechanism for controlling systemic insulin resistance or other biological functions. Materials and Methods: The capitulum of C. indicum was extracted with methanol, and its PPAR‑γ agonistic activity was measured using luciferase assay. The active ingredients were isolated by the activity‑guided fractionations. Results: We isolated (Z)‑tonghaosu and (E)‑tonghaosu, and (E)‑tonghaosu had PPAR‑γ agonistic constituents by the activity‑guided fractionation from the capitulum of C. indicum. The isomer (Z)‑tonghaosu did not show PPAR‑γ‑agonistic activity. Conclusion: (E)‑tonghaosu is one of the active ingredients as PPAR‑γ agonist in the capitulum of C. indicum.

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      Zhang, F., Iwaki, A., Ishiuchi, K., Sugiyama, A., Ohsawa, M., & Makino, T. (2018). Peroxisome Proliferator‑Activated Receptor‑γ Agonistic Effect of Chrysanthemum indicum Capitulum and Its Active Ingredients. Pharmacognosy Magazine, 14(56), 461–464. https://doi.org/10.4103/pm.pm_607_17