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    Antioxidant Effect of Royal Jelly on Immune Status of Hyperglycemic Rats

    Abdullah G. Al-Kushi2★, Eslam A. Header3,4, Naser A. ElSawy5,6, Reham A. Moustafa3, Nehal A. A. Alfky3★ Corresponding author

    1. 1Department of Anatomy, Faculty of Medicine, Departments of.
    2. 2Clinical Nutrition and.
    3. 3Department of Nutrition and Food Science, Faculty of Home Economics, Menofia University, Egypt.
    4. 4Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al Qura University, Makkah, KSA.
    5. 5Department of Anatomy and Embryology, Faculty of Medicine Zagazig University.

    CORRESPONDENCE

    Abdullah G. Al-Kushi

    Clinical Nutrition and.

    dr.alkushi@gmail.com

    Received: 28-02-2018; Revised: 06-04-2018.

    Volume 14, Issue 58 · pp. 528–533 · PUBLISHED 21 November 2018 · DOI: 10.4103/pm.pm_87_18

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Context: Diabetes mellitus and its increasing effect on endocrine functionality have been widely observed. Aims: The present study aims at investigating the histopathological changes of splenic cells in diabetic rats. Subjects and Methods: The experiment was conducted on adult male albino rats. They were categorized into four groups: Group I (negative control; fed with standard basal diet [SBD]), Group II (positive control; fed with SBD), Group III (fed on SBD + dose of 50 mg/kg of body weight royal jelly [RJ]) and Group IV were given orally RJ 100 mg/kg of b.wt. The food intake ratio and body weight gain were monitored on a weekly basis. The blood sample and organ tissue samples were collected at the end of feeding and biochemical and immunological analysis was performed for determining the blood glucose level and immune status of the investigated rats. Superoxide dismutase activity was also determined. Results: The results showed increased antioxidant enzymes and lowered glucose levels in diabetic rats fed with RJ. Conclusion: Histopathology tissues indicated moderate to extreme cellular transformations upon treated rats. The histopathological variations in treated rat cells were found to be evident. For this reason, there is likelihood that RJ may have an effect on splenic tissue repair in diabetic rats.

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      Al-Kushi, A. G., Header, E. A., ElSawy, N. A., Moustafa, R. A., & Alfky, N. A. A. (2018). Antioxidant Effect of Royal Jelly on Immune Status of Hyperglycemic Rats. Pharmacognosy Magazine, 14(58), 528–533. https://doi.org/10.4103/pm.pm_87_18