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    Neuropharmacological Effects of Methanolic Extract of Clerodendrum viscosum Leaves on Wistar Albino Rats

    Meera Rath1★, Ayon Bhattacharya1★, Soumya Santra1, Karmajeet Rath1, Goutam Ghosh3, Bijaya B. Nanda4★ Corresponding author

    1. 1Department of Pharmacology, Institute of Medical Sciences, Siksha ‘O’ Anusandhan University, India.
    2. 2Department of Pharmacology, KPC Medical College, WBUHS, Kolkata, West Bengal, India.
    3. 3Department of Pharmacognosy, School of Pharmaceutical Sciences, S‘O’A University, India.
    4. 4Regional Institute of Planning Applied Economics and Statistics, Government of Odisha, Bhubaneswar, Odisha, India.

    CORRESPONDENCE

    Meera Rath

    Department of Pharmacology, Institute of Medical Sciences, Siksha ‘O’ Anusandhan University, India.

    ayon.bhattacharya23@gmail.com

    Received: 20-05-2018; Revised: 05-09-2018.

    Volume 14, Issue 59s · pp. S507–S514 · PUBLISHED 17 January 2019 · DOI: 10.4103/pm.pm_267_18

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The aim is to study the central nervous system (CNS) depressant, anxiolytic, and antiepileptic activities of methanolic extract of Clerodendrum viscosum (MECV) leaves. Materials and Methods: The study comprised five groups each with 6 Wistar albino rats. The Group 1 or the positive control (phenytoin 30 mg/kg for the epilepsy model, and diazepam 1 mg/kg for the other models), Group 2 or negative control (0.9% NaCl at 10 ml/kg), and Groups 3–5 or the test drug group (MECV at 200, 400, and 800 mg/kg). Actophotometer test, staircase test, maximal electroshock seizure (MES) test, and the thiopentone sodium‑induced sleep test, were used to study the various parameters. Results: The actophotometer test, MES, and staircase test (steps climbed) were analyzed using parametric tests. The sleep induction and staircase test (number of rears) were evaluated using nonparametric tests. A dose‑dependent significant (P < 0.05) response was observed in the actophotometer test, sleep induction, and MES tests in comparison to control. In the staircase test at 200 and 400 mg/kg, increase in the number of steps climbed, and at 800 mg/kg decrease in both the number of steps climbed and rears were observed in comparison to control. Conclusion: MECV showed a dose‑dependent CNS depressant action in the sleep induction and antiepileptic tests. A CNS stimulant action was observed at low dose (200 mg/kg) and depressant action at a higher dose (800 mg/kg) in the staircase test in comparison to control.

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      Rath, M., Bhattacharya, A., Santra, S., Rath, K., Ghosh, G., & Nanda, B. B. (2019). Neuropharmacological Effects of Methanolic Extract of Clerodendrum viscosum Leaves on Wistar Albino Rats. Pharmacognosy Magazine, 14(59s), S507–S514. https://doi.org/10.4103/pm.pm_267_18