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    Article

    Phytochemical analysis and in vitro antioxidant activity of the leaves of Cinnamomum tamala (Buch.-Ham.) Nees & Eberm.

    sulfoxide ‑d MHz)1★★ Corresponding author

    1. 1Number δH (mult., J [Hz]) δC (mult.) HMBC 1 ‑ 120.9 C ‑ 2 8.55 dd (8.5, 1.7) 119.9 CH 4, 6, 7 3 7.46 dt (8.5, 1.7) 131.9 CH 2, 5, 6 4 7.10 dt (8.5, 1.7) 122.4 CH 1, 5, 6 5 7.73 dd (8.5, 1.7) 128.5 CH 1, 3, 6 6 ‑ 138.7 C ‑ 7 ‑ 170.3 C ‑ 8 8.15 brs 7.58 brs ‑ 1, 7 9 9.86 s ‑ 5, 6, 10 10 ‑ 174.2 C ‑ 11 5.97 brd (2.6) 91.1 CH 10, 13 11‑OH 11.97 s ‑ 10 12 4.08 dq (2.6, 6.8) ‑ 10, 11, 13 13 3.28 d (6.8) 31.7 CH3 11 HMBC: Heteronuclear multiple bond correlation experiment.

    CORRESPONDENCE

    sulfoxide ‑d MHz)

    sulfoxide ‑d6, 850 , 214 MHz),Number δH (mult., J [Hz]) δC (mult.) HMBC 1 ‑ 120.9 C ‑ 2 8.55 dd (8.5, 1.7) 119.9 CH 4, 6, 7 3 7.46 dt (8.5, 1.7) 131.9 CH 2, 5, 6 4 7.10 dt (8.5, 1.7) 122.4 CH 1, 5, 6 5 7.73 dd (8.5, 1.7) 128.5 CH 1, 3, 6 6 ‑ 138.7 C ‑ 7 ‑ 170.3 C ‑ 8 8.15 brs 7.58 brs ‑ 1, 7 9 9.86 s ‑ 5, 6, 10 10 ‑ 174.2 C ‑ 11 5.97 brd (2.6) 91.1 CH 10, 13 11‑OH 11.97 s ‑ 10 12 4.08 dq (2.6, 6.8) ‑ 10, 11, 13 13 3.28 d (6.8) 31.7 CH3 11 HMBC: Heteronuclear multiple bond correlation experiment.

    sabrinshaur@gmail.com

    Received: 17-09-2018; Revised: 29-10-2018.

    Volume 15, Issue 61 · pp. 204–207 · PUBLISHED 6 March 2019 · DOI: 10.4103/pm.pm_476_18

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: The main goal of the study is to separate and identify the bioactive constituents from the endophytic fungus Fusarium sp. as well as to evaluate the antimicrobial of the new metabolites. Materials and Methods: The fungus was cultured on a rice medium, and then, the cultures were extracted with ethyl acetate (EtOAc). The EtOAc extract was chromatographed utilizing different chromatographic methods to give five metabolites. The structural determination of these metabolites was carried out by the analyses of various spectroscopic data, in addition to comparison with the formerly reported data. The antifungal and antibacterial potentials were evaluated toward various microbial strains using disc diffusion assay. Results: A new aminobenzamide derivative, namely fusaribenzamide A (2), and four known metabolites: (22E,24R)- stigmasta-5,7,22-trien-3-β-ol (1), adenosine (3), p-hydroxyacetophenone (4), and tyrosol (5) were isolated. Fusaribenzamide A (2) possessed significant antifungal activity toward Candida albicans with minimum inhibitory concentration (MIC) value 11.9 μg/disc compared to nystatin (MIC 4.9 μg/disc). Conclusion: The endophytic fungus Fusarium sp. could be considered as a wealthy pool for the isolation of aminobenzamide derivatives. Fusaribenzamide A may be a candidate for the discovery of a promising antifungal agent.

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      MHz), S. D. (2019). Phytochemical analysis and in vitro antioxidant activity of the leaves of Cinnamomum tamala (Buch.-Ham.) Nees & Eberm.. Pharmacognosy Magazine, 15(61), 204–207. https://doi.org/10.4103/pm.pm_476_18