Volume 15, Issue 61

Original Article

1. Article

   Quality Assessment of Pollen Typhae by High‑performance Liquid Chromatography Fingerprint, Hierarchical Cluster Analysis, and Principal Component Analysis

   Xin Ma, Haimiao Zou, Yibin Pan, Jing Su, Yujiao Qiu, Mingfeng Qiu

   pp. 177–182 · DOI: 10.4103/pm.pm_469_18 · Published 6 March 2019

   Aim: This study aims to establish the quality assessment methods of Pollen Typhae. Materials and Methods: High performance liquid chromatography (HPLC) fingerprint analysis, hierarchical cluster analysis (HCA), and princ…

2. Article

   Chamuangone‑Enriched Garcinia cowa Leaf Extract with Rice Bran Oil: Extraction and Cytotoxic Activity against Cancer Cells

   Pirunrat Sae‑Lim, Supreeya Yuenyongsawad, Pharkphoom Panichayupakaranant

   pp. 183–188 · DOI: 10.4103/pm.pm_472_18 · Published 6 March 2019

   Objectives: Some vegetable oils were determined as an alternative green solvent for extraction of an anticancer compound, chamuangone from G. cowa leaf. The chamuangone‑enriched extract was standardized and evaluated for…

3. Article

   Impact of Ginsenoside‑Rg3 on Catecholamine Secretion in the Perfused Model of the Rat Adrenal Medullae

   Ki‑Hwan Kim, Hyo‑Jeong Lim, Young‑Jae Ki, Dong‑Yoon Lim

   pp. 189–198 · DOI: 10.4103/pm.pm_200_18 · Published 6 March 2019

   Background: The present study was the first attempt to explore the characteristics of ginsenoside-Rg3 (Rg3) on release of catecholamines (CA) in the perfused rat adrenal medullae and also to verify the underlying action …

4. Article

   New Bioactive C15 Acetogenins from the Red Alga Laurencia obtusa

   Mohamed A. Ghandourah, Walied M. Alarif, Nahed O. Bawakid

   pp. 199–203 · DOI: 10.4103/pm.pm_298_18 · Published 6 March 2019

   Objective: With regard to the uniqueness of the red algae of the genus Laurencia as the source of C15‑acetogenins, along with the diversity of biological applications; the acetogenin content of the Red Sea Laurencia obtu…

5. Article

   Phytochemical analysis and in vitro antioxidant activity of the leaves of Cinnamomum tamala (Buch.-Ham.) Nees & Eberm.

   sulfoxide ‑d MHz)

   pp. 204–207 · DOI: 10.4103/pm.pm_476_18 · Published 6 March 2019

   Objective: The main goal of the study is to separate and identify the bioactive constituents from the endophytic fungus Fusarium sp. as well as to evaluate the antimicrobial of the new metabolites. Materials and Methods:…

6. Article

   Optimization of Infrared‑assisted Extraction of Bioactive Lactones from Saussurea lappa L. and their Effects against Gestational Diabetes

   Karim Raafat, Nada El-Darra, Fatima A. Saleh, Hiba N. Rajha, Nicolas Louka

   pp. 208–218 · DOI: 10.4103/pm.pm_380_18 · Published 6 March 2019

   Objectives: The aim of the current study is to optimize an infrared‑assisted extraction (IR‑AE) method for S. lappa bioactive constituents, phytochemically investigate its content, isolate its most active constituent, an…

7. Article

   Dictamnus dasycarpus Turcz., Root Bark Alleviates Oxazolone‑Induced Atopy‑Like Dermatitis in Mice

   Beodeul Yang, Ji Hyo Lyu, Sura Kim, Young Chul Park, Koanhoi Kim, Hyungwoo Kim

   pp. 219–225 · DOI: 10.4103/pm.pm_110_18 · Published 6 March 2019

   Objective: We investigated the anti‑inflammatory effects of D. dasycarpus extract (DDE) using a mouse model with atopic dermatitis (AD)‑like dermatitis. Materials and Methods: The therapeutic effects of DDE on skin lesio…

8. Article

   Antidepressant‑Like Effects of Methanol Extract and Fractions of Hypericum juniperinum Kunth in the Forced Swimming Test

   Laura A. Mejía-Agudelo, Maritza A. Rojas, Mario F. Guerrero-Pabón, Freddy A. Ramos, Leonardo Castellanos

   pp. 226–231 · DOI: 10.4103/pm.pm_341_18 · Published 6 March 2019

   Objective: The aim of this study was to evaluate the antidepressant‑like effects of a methanol extract, as well as ethyl acetate and butanol fractions, obtained from aerial parts of Hypericum juniperinum K. Materials and…

9. Article

   Biological Evaluation and Molecular Docking Study of Metabolites from Salvadora persica L. Growing in Egypt

   Mohammed M. Ghoneim, Wael M. Afifi, Mohamed Ibrahim, Mohamed Elagawany, Maan T. Khayat, Mohamed H. Aboutaleb, Ahmed M. Metwaly

   pp. 232–237 · DOI: 10.4103/pm.pm_361_18 · Published 6 March 2019

   Objective: Exploring the anti-MRSA activity of S. persica L. metabolites and its mechanism of action on a molecular level. Materials and Methods: Structure elucidation of the isolated metabolites was carried out by spect…

10. Article

    Ameliorative Effects of Tannic Acid on Lipopolysaccharide‑induced Sepsis and Acute Lung Injury in Mice

    Ruirui Zhang, Minyan Dang, Shoutian Qiu, Hongyan Gu, Pingping He, Gang Guo, Tao Zhang

    pp. 238–243 · DOI: 10.4103/pm.pm_364_18 · Published 6 March 2019

    Background: Acute lung injury (ALI) caused by endotoxins is a severe complication causing lethal conditions. Prevention of the inflammatory response is necessary to overcome this condition. Tannic acid is a polyphenol kn…

11. Article

    Ameliorative Effect of Sargassum fusiforme Polysaccharides on Oxidative Stress and Inflammation in Ethanol‑induced Gastric Ulcer

    Gangwu Sun, Tao Lian, Bin Yang, Yi Gu, Xiaojia Li

    pp. 244–252 · DOI: 10.4103/pm.pm_457_18 · Published 6 March 2019

    Background: Gastric ulcer is also known as stomach ulcer which is complex with multifactor‑associated disease and shows high prevalent worldwide. It affects most of the people around the world, and the initiation and pro…

12. Article

    Antioxidant and Anti‑caspase‑3 Activity of Chitosan‑Pinus merkusii Extract Nanoparticle on Lead Acetate‑induced Hepatotoxicity

    Sri Agus Sudjarwo, Giftania Wardani, Koerniasari Eraiko, Koerniasari Koerniasari

    pp. 253–258 · DOI: 10.4103/pm.pm_393_18 · Published 6 March 2019

    Objective: In the present study, we investigated the impact of Chitosan‑P. merkusii extract nanoparticle against lead acetate‑induced hepatotoxicity in rats. Materials and Methods: Chitosan‑P. merkusii extract nanopartic…

13. Article

    Gracilaria foliifera (Forssk.) Børgesen Ethanolic Extract Triggers

    Apoptosis via Activation of p53 Expression in HepG2 Cells Sasikumar Shebi, Devaraj Ezhilarasan, John Thomas, Natarajan Chandrasekaran, Amitava Mukherjee

    pp. 259–263 · DOI: 10.4103/pm.pm_379_18 · Published 6 March 2019

    Objective: To investigate the cytotoxic potentials of G. foliifera in HepG2 cells. Materials and Methods: HepG2 cells were fed with culture medium supplemented with different concentrations of ethanolic extract of G. fol…

14. Article

    Pharmacokinetic Study of Hepatoprotective Coumarinolignoids from Cleome viscosa in Mice Using Validated High‑Performance Liquid Chromatography‑Photodiode Array Method

    Kuldeep Singh Yadav, Ranjana Ranjana, Sudeep Tandon, Narayan Prasad Yadav, Karuna Shanker

    pp. 270–276 · DOI: 10.4103/pm.pm_508_18 · Published 6 March 2019

    Objectives: However, the bioavailability and pharmacokinetics of Cliv‑92 are still not clear. The present study is the first validated method which deals with the assay of Cliv‑92 in mouse plasma. Methods: Single‑step sa…

15. Article

    Antiproliferative and Antiangiogenic Effects of Zerumbone from Zingiber zerumbet L. Smith in Sprague Dawley Rat Model of Hepatocellular Carcinoma

    Nozlena Abdul Samad, Ahmad Bustamam Abdul, Heshu Sulaiman Rahman, Rasedee Abdullah, Tengku Azmi Tengku Ibrahim, Hemn Hassan Othman

    pp. 277–282 · DOI: 10.4103/pm.pm_118_18 · Published 6 March 2019

    Aims: This study aimed to investigate the in vivo antiproliferative and antiangiogenesis effects of ZER using rats with diethylnitrosamine‑induced hepatocellular carcinoma (HCC). Materials and Methods: The antiproliferat…

16. Article

    Hepatoprotective and Antioxidant Potential of Radish Seed Aqueous Extract on Cadmium‑induced Hepatotoxicity and Oxidative Stress in Mice

    Qingfeng He, Yunjing Luo, Pingping Zhang, Chengsong An, Ailin Zhang, Xiaodan Li, Lingling You, Cuicui Liu

    pp. 283–289 · DOI: 10.4103/pm.pm_365_18 · Published 6 March 2019

    Objective: The research aimed to investigate the mitigation effect of RSE against Cd‑induced hepatotoxicity in experimental animals. Materials and Methods: The mice were administered intraperitoneally with Cd Chloride (C…

17. Article

    Ameliorating Effects of Geranium koreanum Kom on Esophageal Damage in Reflux Esophagitis via Nuclear Factor‑κB Signaling‑Mediated Anti‑Inflammatory Activities

    Hyeon Hwa Nam, Li Nan, Byung Kil Choo

    pp. 290–297 · DOI: 10.4103/pm.pm_367_18 · Published 6 March 2019

    Objective: In the present study, we wanted to demonstrate the anti‑inflammatory effects of G. koreanum extracts on esophagus damage in acute reflux esophagitis (RE)‑induced rats. Materials and Methods: The anti‑inflammat…

18. Article

    Effect of Gardenia/Acanthopanax‑Medicated Serum on High Level Corticosterone‑induced Pheochromocytoma Cell Apoptosis and Calcium Ion Concentration

    Xiang‑Dong Xu, Xiang‑Qing Xu, Hong Yun Wu, Zhi Jun Li

    pp. 298–303 · DOI: 10.4103/pm.pm_273_18 · Published 6 March 2019

    Objective: This study aims to investigate the effect of gardenia/ acanthopanax‑medicated serum on pheochromocytoma (PC12) cell apoptosis and calcium ion concentration, and explore the antidepression mechanism of gardenia…

19. Article

    Drug interaction between Shoseiryuto Extract or Catechins and Fexofenadine through Organic‑Anion‑transporting Polypeptide 1A2 In vitro

    Katsuhiko Masumoto, Zhiyang Quan, Kan’ichiro Ishiuchi, Takashi Matsumoto, Junko Watanabe, Toshiaki Makino

    pp. 304–308 · DOI: 10.4103/pm.pm_386_18 · Published 6 March 2019

    Objective: Fexofenadine is an anti‑allergy drug frequently used to treat rhinitis, which is absorbed through organic‑anion‑transporting polypeptide (OATP) 1A2 in the intestine. Clinical studies have revealed that grapefr…

20. Article

    Neuroprotective Potential of Methanolic Extract of Saraca asoca Bark against Doxorubicin‑Induced Neurotoxicity

    Sri Pragnya Cheruku, Mallikarjuna Rao Chamallamudi, Grandhi Venkata Ramalingayya, Subhankar Biswas, Karthik Gourishetti, Krishnadas Nandakumar, Raviraj Devkar, Sanchari Basu Mallik, Madhavan Nampoothiri

    pp. 309–316 · DOI: 10.4103/pm.pm_79_18 · Published 6 March 2019

    Aim: The present study was designed to assess the neuroprotective potential of Saraca asoca bark against Dox‑induced neurotoxicity, considering its previously reported anticlastogenic effect. Materials and Methods: Metha…

21. Article

    Anti‑Inflammatory Activity of Corylopsis coreana Uyeki Extracts and Isolated Compounds by Inhibiting Nitric Oxide and Cytokine Production

    Jun Yin, HyeSoo Wang, MinWon Lee

    pp. 317–321 · DOI: 10.4103/pm.pm_144_18 · Published 6 March 2019

    Aims: To study the anti‑inflammatory effects of C. coreana Uyeki leaf and bark extracts as well as their major active compounds, we evaluated in vitro levels of tumor necrosis factor‑α (TNF‑α), interleukin‑6 (IL‑6), and …

22. Article

    Antinociceptive Activity of the Peptide Fraction from the Venom of Social Wasp Pseudopolybia vespiceps Testacea

    Lilian Carneiro Dos Anjos, Jacqueline Coimbra Gonçalves, Bruna Ramos De Araujo, Marcia Renata Mortari

    pp. 322–326 · DOI: 10.4103/pm.pm_238_18 · Published 6 March 2019

    Background: The genus <em>Crotalaria</em> (Fabaceae) is known for its diverse pharmacological activities. Objective: The present study was aimed to evaluate the anti-inflammatory and antioxidant activities of <em>Crotala…

23. Article

    Cucurbita argyrosperma Seed Extract Ameliorating Oxidative Stress in H9c2 Cardiomyocytes through Suppression of Intracellular Reactive Oxygen Species Production

    Rosa Martha Perez-Gutierrez, Maria Fernanda Estrella-Mendoza, Javier Flores Estrada, Rebeca Lopez Marure

    pp. 327–334 · DOI: 10.4103/pm.pm_432_18 · Published 6 March 2019

    Background: Oxidative stress induced by the excessive reactive oxygen species (ROS) generation is involved in the pathogenesis of various diseases. Methanol extract from Cucurbita argyrosperma (CM) was used to test for a…

24. Article

    Protective Effects of Genistein Alleviate Alcohol-Induced Liver Injury in Rats

    Wanlapa Leelananthakul, Duangporn Werawatganon, Naruemon Klaikeaw, Maneerat Chayanupatkul

    pp. 342–347 · DOI: 10.4103/pm.pm_530_18 · Published 6 March 2019

25. Article

    Determination of Three Active Components in Euphorbia humifusa Willd. Using High‑performance Liquid Chromatography with Diode‑array Detection and Autophagy and Apoptosis Analysis of Normal Rat Kidney and HeLa Cells

    Shuge Tian, E. Wen, Na Mi, Hui Li

    pp. 348–355 · DOI: 10.4103/pm.pm_348_18 · Published 6 March 2019

    Objective: To evaluate the anticervical cancer activity of EH and its main active ingredient Gallic acid (GA) by studying on autophagy and apoptosis of normal rat kidney (NRK) and HeLa cell lines, respectively. Materials…

26. Article

    Photoprotective Activity of Medicinal Plants From the Caatinga Used as Anti-inflammatories

    Bruno de Almeida Andrade, Allan Jonathan Chernichiarro Corrêa, Ana Klarissa Soares Gomes, Patrícia Maria da Silva Neri, Tadeu José da Silva Peixoto Sobrinho, Thiago Antônio de Sousa Araújo, Valerium Thijan Nobre de Almeida e Castro, Elba Lúcia Cavalcanti de Amorim

    pp. 356–361 · DOI: 10.4103/pm.pm_482_18 · Published 6 March 2019

    Objective: The present study aims to determine the in vitro sun protection factor (SPF) of 15 species from the Caatinga region used in popular medicine as anti‑inflammatories. Materials and Methods: Samples of duly ident…