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    Biological Evaluation and Molecular Docking Study of Metabolites from Salvadora persica L. Growing in Egypt

    Mohammed M. Ghoneim2,3, Wael M. Afifi2, Mohamed Ibrahim4, Mohamed Elagawany5, Maan T. Khayat6, Mohamed H. Aboutaleb7, Ahmed M. Metwaly2★★ Corresponding author

    1. 1Department of Pharmacognosy, Faculty of Pharmacy, Al‑Azhar University, Cairo, Egypt.
    2. 2Department of Natural Products, School of Pharmacy, Almaarefa Colleges for Science and Technology, Riyadh, Egypt.
    3. 3Department of Organic Chemistry, College of Pharmacy, Misr University for Science and Technology, Al‑Motamayez District, Egypt.
    4. 4Department of Pharmaceutical Organic Chemistry, College of Pharmacy, Damnhour University, Damnhour, Egypt.
    5. 5Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudia Arabia, Egypt.
    6. 6Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University, New Damietta 34517, Egypt.

    CORRESPONDENCE

    Ahmed M. Metwaly

    Department of Natural Products, School of Pharmacy, Almaarefa Colleges for Science and Technology, Riyadh, Egypt.

    ametwaly@azhar.edu.eg

    Received: 04-07-2018; Revised: 04-08-2018.

    Volume 15, Issue 61 · pp. 232–237 · PUBLISHED 6 March 2019 · DOI: 10.4103/pm.pm_361_18

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: Exploring the anti-MRSA activity of S. persica L. metabolites and its mechanism of action on a molecular level. Materials and Methods: Structure elucidation of the isolated metabolites was carried out by spectroscopic data (one-dimensional and two-dimensional nuclear magnetic resonance). The biological activities of the isolated metabolites against MRSA were evaluated and the molecular mode of action against the dehydrosqualene synthase enzyme have been done. Results: Four compounds have been isolated and identifies to be; apigenin (1), luteolin (2), astragalin (3), and kaempferol-3-O-rhamnoside (4). Compounds 1–4 showed good anti-MRSA activities with IC50 values of 10.3, 11.5, 3.5, and 4.5 μg/mL, respectively. In consistent, astragalin and kaempferol-3 rhamnoside showed close high docking scores. Herein, we are reporting the molecular determinates of activity of these new scaffolds as anti-MRSA, which would be of great importance to developing new anti-MRSA candidates.

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      Ghoneim, M. M., Afifi, W. M., Ibrahim, M., Elagawany, M., Khayat, M. T., Aboutaleb, M. H., & Metwaly, A. M. (2019). Biological Evaluation and Molecular Docking Study of Metabolites from Salvadora persica L. Growing in Egypt. Pharmacognosy Magazine, 15(61), 232–237. https://doi.org/10.4103/pm.pm_361_18