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    Article

    Hepatoprotective and Antioxidant Potential of Radish Seed Aqueous Extract on Cadmium‑induced Hepatotoxicity and Oxidative Stress in Mice

    Qingfeng He2,3, Yunjing Luo2★, Pingping Zhang3, Chengsong An3, Ailin Zhang3, Xiaodan Li3, Lingling You3, Cuicui Liu3★ Corresponding author

    1. 1College of Life Science and Bioengineering, Beijing University of Technology, Chaoyang, Beijing, China.
    2. 2Department of Food Quality and Safety, College of Food Science and Biotechnology, Tianjin Agricultural University, Xiqing, Tianjin, China.

    CORRESPONDENCE

    Yunjing Luo

    Department of Food Quality and Safety, College of Food Science and Biotechnology, Tianjin Agricultural University, Xiqing, Tianjin, China.

    luoyj@bjut.edu.cn

    Received: 08-07-2018; Revised: 04-08-2018.

    Volume 15, Issue 61 · pp. 283–289 · PUBLISHED 6 March 2019 · DOI: 10.4103/pm.pm_365_18

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: The research aimed to investigate the mitigation effect of RSE against Cd‑induced hepatotoxicity in experimental animals. Materials and Methods: The mice were administered intraperitoneally with Cd Chloride (CdCl2, 75 mg/kg b. wt) as a positive control to compare RSE. The hepatic function and antioxidant status were assessed in liver tissue of poisoned and control mice. Results: Levels of serum hepatic enzymes (aspartate transaminase: AST and alanine transaminase: ALT) as well as total bilirubin were significantly increased in Cd‑exposed mice. In addition, Cd exposure elicited enhancement of oxidative stress level. Co‑treatment with RSE (200 and 400 mg/kg b. wt) significantly decreased the serum levels of liver function biomarkers. Furthermore, RSE treatment showed a significant reduction of lipid peroxidation and increase of enzyme and glutathione concentrations. Histopathological analysis was parallel to these biochemical findings. Conclusion: The results clearly demonstrated that RSE is effective for ameliorating hepatic cytotoxicity and oxidative damage arising from Cd exposure.

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      He, Q., Luo, Y., Zhang, P., An, C., Zhang, A., Li, X., You, L., & Liu, C. (2019). Hepatoprotective and Antioxidant Potential of Radish Seed Aqueous Extract on Cadmium‑induced Hepatotoxicity and Oxidative Stress in Mice. Pharmacognosy Magazine, 15(61), 283–289. https://doi.org/10.4103/pm.pm_365_18