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    Article

    Impact of Microwaves on the Extraction Yield of Phenolics, Flavonoids, and Triterpenoids from Centella Leaves: An Approach toward Digitized Robust Botanical Extraction

    Kamal Kumar Sen2, Kavi Bhushan Singh Chouhan3, Roshni Tandey3, Rajendra Mehta2, Vivekananda Mandal3★★ Corresponding author

    1. 1Department of Rural Technology, Guru Ghasidas Central University, India.
    2. 2Department of Pharmacognosy, Institute of Pharmacy, Guru Ghasidas Central University, Bilaspur Chhattisgarh, India.

    CORRESPONDENCE

    Vivekananda Mandal

    pharmafriend@rediffmail.com

    Received: 28-02-2019; Revised: 14-03-2019.

    Volume 15, Issue 64s · pp. S267–S273 · PUBLISHED 26 August 2019 · DOI: 10.4103/pm.pm_99_19

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: The aim of this study is to develop a robust optimized microwave‑based extraction protocol for improved yield of phenolics, flavonoids, and triterpenoids principles. Materials and Methods: Microwave power and extraction time were critically optimized along with the effect of moisture content through sample pretreatment. Effect of optimized operating conditions on the biological integrity of the extract and on the extraction of other nutraceutical principles was also evaluated. Results were compared to traditional extraction methods. Results: The final optimum extraction conditions were 50% microwave power, 6‑min irradiation time, and 54% moisture content for maximum yield of phenolics and triterpenoids, whereas for flavonoids, optimum microwave power was 40% with other conditions remaining same. The proposed method was found to be three‑fold better than 36 h of Soxhlet extraction and produced 200 times lesser carbon load than Soxhlet. Improved yield of other nutraceutical principles with better anti‑oxidant activity was recorded for the proposed method. Conclusion: Switching to such greener technology is now the need of the hour. This research is a sincere effort to showcase the potential of green chemistry in the herbal drug industry.

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      Sen, K. K., Chouhan, K. B. S., Tandey, R., Mehta, R., & Mandal, V. (2019). Impact of Microwaves on the Extraction Yield of Phenolics, Flavonoids, and Triterpenoids from Centella Leaves: An Approach toward Digitized Robust Botanical Extraction. Pharmacognosy Magazine, 15(64s), S267–S273. https://doi.org/10.4103/pm.pm_99_19