Volume 15, Issue 64s

The Antioxidant Paradox

Ashok Kumar Tiwari

pp. S173–S175 · DOI: 10.4103/0973-1296.265039 · Published 26 August 2019

Pterodon emarginatus Hydroalcoholic Extract: Antioxidant and Photoprotective Activities, Noncytotoxic Effect, and Perspective of Obtaining Formulations with Photochemoprotective Activity

Wannessa Lenyse Rocha de Carvalho, Larissa Ceres Moreira, Marize Campos Valadares, Danielle Guimaraes A. Diniz

pp. S176–S182 · DOI: 10.4103/pm.pm_580_18 · Published 26 August 2019

Objective: This study aims to investigate the antioxidant and photoprotective activities and cytotoxicity effect of hydroalcoholic extract of P. emarginatus (HEP) and obtain formulations with photochemoprotective activit…

Optimization of Ultrasound‑Assisted Extraction of L‑Ascorbic Acid from Adansonia digitata (Linn.) and Evaluation of its Antityrosinase Activity

Hussein Zeitoun, Sabine Lone, Dominique Salameh, Roger Lteif

pp. S183–S188 · DOI: 10.4103/pm.pm_615_18 · Published 26 August 2019

Objectives: The aim of this study was to optimize the extraction of AA from the fruit pulp of A. digitata by ultrasound‑assisted extraction and to evaluate the antityrosinase activity of the extract. Materials and Method…

Anti-inflammatory and Analgesic Activities of Crotalaria pallida Aiton

in CDCl3.[18]

pp. S189–S196 · DOI: 10.4103/pm.pm_643_18 · Published 26 August 2019

Background: Turbinaria conoides, a brown seaweed, is a rich source of oxygenated fucosterols which are capable of suppressing the proliferation of cancer cells. Their specific therapeutically significant biological activ…

Anti-adipogenic Effect of Terminalia chebula Fruit Aqueous Extract in 3T3-L1 Preadipocytes

Anuj Kumar Borah, Pooja Rani Kuri, Archana Singh, Sougata Saha

pp. S197–S204 · DOI: 10.4103/pm.pm_108_19 · Published 26 August 2019

Background: Phytoextracts, due to its complex nature of formulations yet little or no side effects, have been pursued as alternative medicine for the treatment of complex metabolic disorders such as obesity. One of the a…

Liquid Chromatography–Mass Spectrometry/Mass Spectrometry Method Development for the Determination of Carbaryl Residue in Honey

S. Venu, K. Santhi, Ashish Rawson, R. Paranthaman, K. Sureshkumar

pp. S205–S211 · DOI: 10.4103/pm.pm_641_18 · Published 26 August 2019

Objective: Liquid chromatography– mass spectrometry/mass spectrometry (LC‑MS/MS) method development for the determination of Carbaryl insecticide in honey and Comparisons of different extraction techniques to determine t…

Anti‑diabetic Activities of Dactylorhiza hatagirea Leaf Extract in 3T3‑L1 Cell Line Model

Murad Alsawalha, Abeer Mohammed Al-Subaei, Reem Yousuf Al-Jindan, Srinivasa Rao Bolla, Dwaipayan Sen, Janardhana Papayya Balakrishna, Padma Kanchi Ravi, Shiva Shankar Reddy Gollapalli, Vishnu Priya Veeraraghavan, Aruthra Arumugam Pillai, Joel Palpath Joseph, Mohammed Salahuddin, Surapaneni Krishna Mohan

pp. S212–S217 · DOI: 10.4103/pm.pm_8_19 · Published 26 August 2019

Background: Diabetes is an endocrine disorder that results in altered carbohydrate, protein, and lipid metabolism. Several synthetic drugs used to treat diabetes have adverse effects on prolonged usage. This has given th…

Nanoencapsulation of Tinospora cordifolia (Willd.) Using Poly (D, L‑lactide) Nanoparticles: Yield Optimization by Response Surface Methodology and in silico Modeling with Insulin Receptor Tyrosine Kinase

A. Ragavee, Selvaraj Asha Devi

pp. S218–S227 · DOI: 10.4103/pm.pm_678_18 · Published 26 August 2019

Background: Tinospora cordifolia (TC) is a widely used shrub in Ayurveda system of medicine. The main chemical constituent reported from this shrub is alkaloid with nitrogen heterocycles such as tropane alkaloids, thiazo…

Volatile and Phenolic Compounds in Freshwater Diatom Nitzschia palea as a Potential Oxidative Damage Protective and Anti‑Inflammatory Source

B. L. Sudarshan, P. K. Maheshwar, P. Shanmukha Priya, K. R. Sanjay

pp. S228–S236 · DOI: 10.4103/pm.pm_649_18 · Published 26 August 2019

Background: Nitzschia palea is a freshwater diatom species (Bacillariophyceae), is easy to cultivate, and is a primary producer of organic matters in aquatic environments. Materials and Methods: In this study, proximate …

Anti‑Proliferative and Apoptotic Effects of Rheum emodi on Human Breast Adenocarcinoma, MCF‑7 Cells, and Antimicrobial Effectiveness against Selected Bacterial Strains

Juhi Rais, Asif Jafri, Shabana Bano, Neelam Shivnath, Madhu Tripathi, Md. Arshad

pp. S237–S242 · DOI: 10.4103/pm.pm_674_18 · Published 26 August 2019

Objective: In this study, we have investigated the anti‑cancerous potentials of RE ethanolic extract on human breast adenocarcinoma cells MCF‑7 and its antimicrobial effect against selected pathogenic bacterial strains. …

Identification and Quantification of Fucoxanthin in Selected Carotenoid‑Producing Marine Microalgae and Evaluation for their Chemotherapeutic Potential

Muthukumaran Peraman, Saraswathy Nachimuthu

pp. S243–S249 · DOI: 10.4103/pm.pm_64_19 · Published 26 August 2019

Objective: The objective of this research is to evaluate the suitability of the selected marine microalgae for biological activities and to perform the identification and quantification of fucoxanthin in their methanol e…

Osteogenic Activity of Resveratrol in Human Fetal Osteoblast Cells

Aarti Abhishek Shah, Karthik Gourishetti, Yogendra Nayak

pp. S250–S255 · DOI: 10.4103/pm.pm_619_18 · Published 26 August 2019

Objective: The main objective of the study was to evaluate RSV on the proliferation and differentiation of immortalized human fetal osteoblastic cells 1.19 (hFOB). Materials and Methods: The osteoblastic cell proliferati…

High‑Performance Thin‑Layer Chromatography Marker‑Based Standardization of Piperine, Asiaticoside, and Withanolide‑A in the Developed Polyherbal Formulation and in vitro Evaluation of Acetylcholinesterase Inhibition

Vasudev Pai, K. S. Chandrashekar, Polu Picheshwara Rao, Manganahalli Manjunath Setty

pp. S256–S260 · DOI: 10.4103/pm.pm_5_19 · Published 26 August 2019

Objective: The present work aims to develop the high‑performance thin‑layer chromatography (HPTLC) marker‑based standardization of polyherbal formulation using Piperine, Asiaticoside, and Withanolide‑A and in vitro acety…

Anticancer Effect of Different Extracts of Cynanchum acutum L. Seeds on Cancer Cell Lines

Ahmed Mohamed Mohamed Youssef, Zeinab Ahmed Said El‑Swaify, Yousef Mohammed Al‑Saraireh, Saed Mohammed Al‑Dalain

pp. S261–S266 · DOI: 10.4103/pm.pm_676_18 · Published 26 August 2019

Objective: The anticancer effects of ether, chloroform subfraction, and aqueous extracts of C. acutum seeds were investigated. Materials and Methods: C. acutum seeds were extracted by ether, chloroform, and aqueous. Then…

Impact of Microwaves on the Extraction Yield of Phenolics, Flavonoids, and Triterpenoids from Centella Leaves: An Approach toward Digitized Robust Botanical Extraction

Kamal Kumar Sen, Kavi Bhushan Singh Chouhan, Roshni Tandey, Rajendra Mehta, Vivekananda Mandal

pp. S267–S273 · DOI: 10.4103/pm.pm_99_19 · Published 26 August 2019

Objective: The aim of this study is to develop a robust optimized microwave‑based extraction protocol for improved yield of phenolics, flavonoids, and triterpenoids principles. Materials and Methods: Microwave power and …

Efficacy of Trigonella foenum‑graecum Seed Extract on Ovariectomy‑Induced Hyperlipidemia, Oxidative Stress, and Histopathological Changes in Rats

Takkella Nagamma, Anjaneyulu Konuri, Rajalekshmi Maheshwari, E. G. Padmanabha Udupa, Yogendra Nayak

pp. S274–S279 · DOI: 10.4103/pm.pm_4_19 · Published 26 August 2019

Objectives: This study was to standardize Trigonella foenum‑graecum (fenugreek, TFG) seed extract by high‑performance thin‑layer chromatography (HPTLC) and to test its efficacy in ovariectomy‑induced hyperlipidemia in ra…

Potential Cyclooxygenase (COX-2) Enzyme Inhibitors from Myrica nagi-from in-silico to in-vitro Investigation

H. P. Prashanth Kumar, Prachurjya Panda, Prashantha Karunakar, Kotikalapudi Shiksha, Laxmi Singh, Nijalingappa Ramesh, Talambedu Usha, Sushil Kumar Middha

pp. S280–S287 · DOI: 10.4103/pm.pm_56_19 · Published 26 August 2019

Objectives: Our principal focus was to identify COX‑2 enzyme inhibitors, safer and natural anti‑inflammatory compounds from M. nagi. Protein–ligand interaction has a significant role in structure‑based drug design. Mater…

Caesalpinia pulcherrima Arrests Cell Cycle and Triggers Reactive Oxygen Species‑Induced Mitochondrial‑Mediated apoptosis and Necroptosis via Modulating Estrogen and Estrogen Receptors

Nikhil S. Sakle, Deepak Lokwani, Santosh Namdeo Mokale

pp. S288–S297 · DOI: 10.4103/pm.pm_100_19 · Published 26 August 2019

Objective: The present study was aimed at investigating the chemomodulatory potential of C. pulcherrima flowers in breast cancer and explaining its possible mechanism. Materials and Methods: The cytotoxic potential of et…

Pila globosa Snail Extract Inhibits Osteoclast Differentiation via Downregulation of Nuclear Factor κB and Nuclear Factor of

Activated T‑Cells c1 Signaling Pathways Shanmuganathan Pandiarajan, Shila Samuel, Tholcopiyan Loganathan, Shyam Sundar Jaganathan, Thiagarajan Krishnamurthi, Radhakrishnan Sarangapani, Vinod Kumar Anandan, Ramasubramanian Venkatachalam

pp. S298–S306 · DOI: 10.4103/pm.pm_39_19 · Published 26 August 2019

Objective: The current study describes for the first time that Pila globosa snail extract inhibits osteoclastogenesis in vitro and thus suppresses bone loss in ovariectomy‑induced rat model. Materials and Methods: Ovarie…

Tetrahydronaphthalene Lignan Glucoside from Crataeva nurvala: Apoptotic Induction, Antimigration, and in silico Analysis

Nandan Sarkar, Puneet Kacker, Hina Amin, Priyanka Narad, Anindya Goswami, Sabari Ghosal

pp. S307–S312 · DOI: 10.4103/pm.pm_624_18 · Published 26 August 2019

Objective: Isolation, characterization, and evaluation of cytotoxic activity of bioactive fraction of C. nurvala and identification of molecular target prediction by suitable method. Materials and Methods: Gravity column…

In silico Molecular Docking and Comparative in-vitro Analysis of Ethyl 3, 4, 5‑Trihydroxybenzoate and its Derivative Isolated from Hippophae rhamnoides Leaves as Free Radical Scavenger and Anti‑Inflammatory Compound

P K Pandey, Bahar Ahmed, Haider A. Khan, M. Bala, Jagdish Prasad

pp. S313–S319 · DOI: 10.4103/pm.pm_625_18 · Published 26 August 2019

Objective: The objective of this study is to determine the antioxidant and anti‑inflammatory potential of GAE and GA derivatives isolated from H. rhamnoides leaves, in vitro and in silico approach target on COX‑2 and SOD…

Decalepis hamiltonii and its Bioactive Compounds Protects Isoproterenol‑Induced Myocardial Oxidative Stress in Rats

Anupama Sindhaghatta Kariyappa, Sowbhagya Ramachandregowda, Santosh Anand, Bhagyalakshmi Dundaiah

pp. S320–S327 · DOI: 10.4103/pm.pm_642_18 · Published 26 August 2019

Objective: The present study was designed to evaluate the cardioprotective potential of Dh extract and its bioactive compounds on region‑specific responses against isoproterenol (ISO)‑induced myocardial injury in male Wi…

Morinda Citrifolia (Noni) Fruit Protects the Exocrine Pancreatic Dysfunction Against L‑Arginine Induced Acute Pancreatitis in Rats

Veena Gadicherla, Siva Reddy Challa, Mandava V. Basaveswara Rao, Pavan Kumar Kunda, Ramakrishna Prudhvi

pp. S328–S334 · DOI: 10.4103/pm.pm_661_18 · Published 26 August 2019

Background: The genus <em>Crotalaria</em> (Fabaceae) is known for its diverse pharmacological activities. Objective: This study aimed to evaluate the antioxidant, anti-inflammatory, and cytotoxic activities of <em>Crotal…

Effect of Ethanolic Extract of Excoecaria agallocha Leaves on the Cytotoxic Activity and Cell Cycle Arrest of Human Breast Cancer Cell Lines – MCF‑7

Palagati Rohith Kumar Reddy, Priya Durairaj, Palaniyandi Thiruvanavukkarasu, Rajeswary Hari

pp. S346–S351 · DOI: 10.4103/pm.pm_237_19 · Published 26 August 2019

Objective: The aim of the present study is to analyze the cytotoxic potential of Exoecaria agallocha leaves in terms of its antiproliferative activity, apoptosis induction, and cell cycle arrest in the breast cancer MCF‑…

Primary Skin Irritation and Dermal Sensitization Assay: In vivo Evaluation of the Essential Oil from Piper sarmentosum Roxb.

Nor Zafirah Abu Bakar, Hidayatulfathi Othman, Nor Fadilah Rajab, Siti Balkis Budin, Ahmad Fuad Shamsuddin

pp. S352–S358 · DOI: 10.4103/pm.pm_635_18 · Published 26 August 2019

Background: Piper sarmentosum Roxb. is a traditional medicine which can also be consumed as a vegetable. Despite the availability of a variety of toxicological data on extracts of this plant, to our knowledge, until now,…

Catha edulis‑induced Skeletal Muscle Toxicity in Experimental Rats via Regulation of Rhabdomyolysis Biomarkers

Syam Mohan, Emad Shaheen, Yasmin O. El‑Amir, Hussein A. Khadashi, Saida S. Ncibi, Abdullah Farasani, Siddig Ibrahim Abdelwahab

pp. S359–S365 · DOI: 10.4103/pm.pm_142_19 · Published 26 August 2019

Background: The genus <em>Crotalaria</em> (Fabaceae) is known for its diverse pharmacological activities. Objective: The present study was aimed to evaluate the anti-inflammatory and analgesic activities of the methanoli…

Naphthazarins as Cytotoxic Agents isolated from Arnebia euchroma

Nidhi Sharma, Ashu Gulati, Dharmesh Kumar, Yogendra Padwad

pp. S366–S370 · DOI: 10.4103/pm.pm_115_19 · Published 26 August 2019

Background: Currently, many compounds of different medicinal plants are under investigation for curing various types of cancers. In extension with this ongoing research, Arnebia euchroma is taken for the study of cytotox…