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    Antioxidant Effect of Terminalia arjuna Extract Against Acetaminophen‑Induced Hepatotoxicity via the Regulation of Cytochrome P450 2E1, Phosphatidylinositol‑3‑Kinase/Protein Kinase B

    Senthilganesh P. Kannappan2,3★, Gunapriya Raghunath4, Senthilkumar Sivanesan2, Rajagopalan Vijayaraghavan2, Madhankumar Swaminathan2★ Corresponding author

    1. 1Department of Research and Development, Saveetha Institute of Medical and Technical Sciences, India.
    2. 2Department of Anatomy, Apollo Institute of Medical Science and Research, Chittoor, Andhra Pradesh, India.
    3. 3Department of Anatomy, Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India.

    CORRESPONDENCE

    Senthilganesh P. Kannappan

    Department of Anatomy, Apollo Institute of Medical Science and Research, Chittoor, Andhra Pradesh, India.

    senthilganesh52@gmail.com

    Received: 02-08-2019; Revised: 27-09-2019.

    Volume 16, Issue 67 · pp. 13–20 · PUBLISHED 11 February 2020 · DOI: 10.4103/pm.pm_339_19

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Aim: The present study explored the therapeutic in detail antioxidants and effect of aqueous Terminalia arjuna (TA) bark extract against acetaminophen (APAP) induced hepatotoxicity through studies on serum marker enzymes, phosphatidylinositol3kinase/protein kinase B (PI3K/AKT) pathway, CYP2E1 evaluations. Biochemical, antioxidant, cytochrome P450 2E1 (CYP2E1) enzyme, and PI3K/AKT cell signal enzymes were observed with the appropriate methods of study. Materials and Methods: The animals were divided into five groups (each having six animals): control group, Acetaminophen (APAP) toxic group, N‑acetylcysteine (NAC) group, TA 250 mg/kg group, and TA 500 mg/kg group. APAP toxic dose of 750 mg/kg body weight was administered along with 0.5% of hydroxypropyl cellulose (vehicle) 24 h before sacrificing the animal. Results: The biochemical, antioxidant, Histopathological, CYP2E1 enzyme, PI3K, AKT protein expression analysis were shown increased antioxidant level, increased PI3K/ AKT level, decreased liver function marker level and decreased CYP2E1 level in TA500 mg group compared with APAP toxic group (P < 0.01). The findings suggest that TA (500mg/kg) drug reduced Acetaminophen toxicity via antioxidant and molecular mechanisms. Conclusion: The present study concluded that TA 500 mg/kg high dose is more effective to restore the liver tissue through APAPinduced hepatotoxicity in Wistar albino rats.

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      Kannappan, S. P., Raghunath, G., Sivanesan, S., Vijayaraghavan, R., & Swaminathan, M. (2020). Antioxidant Effect of Terminalia arjuna Extract Against Acetaminophen‑Induced Hepatotoxicity via the Regulation of Cytochrome P450 2E1, Phosphatidylinositol‑3‑Kinase/Protein Kinase B. Pharmacognosy Magazine, 16(67), 13–20. https://doi.org/10.4103/pm.pm_339_19