Volume 16, Issue 67

Original Article

1. Article

   Effects of Baicalin on Pharmacokinetics of Florfenicol and mRNA Expression of CYP1A2, CYP2C11, CYP3A1, UGT1A1, MDR1, and ABCC2 in Rats

   Si‑Cong Li, Xu‑Ting Li, Bin Wang, Rui Yang, Min Zhang, Jin‑Liang Li, Wei Huang, Liang Cao, Song‑Yang Xiao

   pp. 1–6 · DOI: 10.4103/pm.pm_261_19 · Published 11 February 2020

   Background: The traditional Chinese medicine Scutellariae radix is often used in combination with antibiotics, such as florfenicol, in Chinese veterinary medicine. Baicalin (5, 6, 7‑trihydroxyflavone‑7‑β‑D‑glucu ronide) …

2. Article

   Protective Effect of Ferulic Acid on Human Umbilical Vein Endothelial Cell Model of Cold Stress

   Si Huang, Shengsuo Ma, Di Zhang, Bing Yang, Jianxin Sun, Meina Huang, Haoming Lin, Meijing Xie, Guoping Zhao

   pp. 7–12 · DOI: 10.4103/pm.pm_631_18 · Published 11 February 2020

   Aims: The aim of the present study was to investigate the potential mechanism of FA by suppressing Transient receptor potential cation channel subfamily M member 8 (TRPM8) channels and regulating endothelial nitric oxide…

3. Article

   Pharmacokinetic Comparisons of Six Major Bioactive Components in Rats after Oral Administration of Crude and Saltwater Processed Phellodendri amurensis Cortex by Ultra‑performance Liquid Chromatography–Mass Spectrometry/Mass Spectrometry

   Fan Zhang, Li Meng, Peng‑Peng Liu, Guo‑Shun Shan, Tian‑Zhu Jia

   pp. 111–118 · DOI: 10.4103/pm.pm_257_19 · Published 11 February 2020

   Background: The Phellodendri amurensis cortex is a traditional Chinese medicine with multiple pharmacodymic uses (antibacterial, anti‑inflammation, antitumor, etc). It is often processed by saltwater to strengthen its ef…

4. Article

   Astragaloside Accelerates Fracture Healing via Modulating

   miR‑122/p miR‑122/p, miR‑221/RUNX2 Signaling Pathways

   pp. 119–127 · DOI: 10.4103/pm.pm_656_18 · Published 11 February 2020

   Background: Astragaloside (AS) has been clinically used in the management of fracture, but the underlying mechanism of AS involved in fracture healing is still unknown, so the objective of our study was to explore the ab…

5. Article

   Phytochemical Profile of the Aerial Parts of Rehmannia glutinosa Liboschitz var. purpurea Makino

   Huu Tung Nguyen, Thi Ngan Dang, Takuhiro Uto, Tomoe Ohta, Hitoshi Watanabe, Yukihiro Shoyama

   pp. 128–131 · DOI: 10.4103/pm.pm_243_19 · Published 11 February 2020

   Objective: The objective was to study on chemical constituents of the aerial parts of the title plant and evaluate the aerial parts as a supplementary source for Rehmanniae radix. Materials and Methods: Solvent extractio…

6. Article

   Antioxidant Effect of Terminalia arjuna Extract Against Acetaminophen‑Induced Hepatotoxicity via the Regulation of Cytochrome P450 2E1, Phosphatidylinositol‑3‑Kinase/Protein Kinase B

   Senthilganesh P. Kannappan, Gunapriya Raghunath, Senthilkumar Sivanesan, Rajagopalan Vijayaraghavan, Madhankumar Swaminathan

   pp. 13–20 · DOI: 10.4103/pm.pm_339_19 · Published 11 February 2020

   Aim: The present study explored the therapeutic in detail antioxidants and effect of aqueous Terminalia arjuna (TA) bark extract against acetaminophen (APAP) induced hepatotoxicity through studies on serum marker enzymes…

7. Article

   Study on the Inhibition of PLD on IAV-induced Pulmonary Macrophage Based on Autophagy and Apoptosis

   Ling Li, Yi Ning, Ke Wei, Jue Hu, Tao Wu, Cheng Zhao, Fang‑Guo Lu, Qing‑Hu He

   pp. 132–139 · DOI: 10.4103/pm.pm_207_19 · Published 11 February 2020

   Background: Platycodin D (PLD) comes from the main triterpenoid saponins in the dry roots of Platycodon grandiflorum, which has been used in traditional Chinese medicine in the treatment of respiratory disease. This stud…

8. Article

   Cytotoxicity, Phagocytic Activity, and Leishmanicidal Potential of Extract Standardized in Geranylgeraniol Obtained from the Fruit of Pterodon emarginatus Vogel

   Suzana Ferreira Alves, Clayson Moura Gomes, Matheus Gabriel de Oliveira, Wanessa Machado de Andrade, Larissa Cleres Moreira, Leonardo Luiz Borges, Cláudio Carlos da Silva, Graciella Ottoni de Souza, Vinicius Barreto da Silva, Marize Campos Valadares, Maria Teresa Freitas Bara

   pp. 140–147 · DOI: 10.4103/pm.pm_231_19 · Published 11 February 2020

   Background: P. emarginatus is a Brazilian medicinal plant with several constituents shown to have anti‑inflammatory, antinociceptive, antimicrobial, and antiproliferative activities. Materials and Methods: The standardiz…

9. Article

   A Rapid and Efficient Approach Based on Ultra‑High Liquid Chromatography Coupled with Mass Spectrometry for Identification in vitro and in vivo Constituents from Shizao Decoction

   Yu-Mei Wang, Qi Liu, Wen-Hao Fu, Ai-Hua Zhang

   pp. 148–155 · DOI: 10.4103/pm.pm_329_19 · Published 11 February 2020

   Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant used in traditional medicine for bone healing. Objective: The present…

10. Article

    Influence of Spectral Light Composition on Flavones Formation in Callus Culture of Scutellaria baicalensis Georgi

    Anna Yurievna Stepanova, Alexandra Ivanovna Solov’yova, Svetlana Andreevna Salamaikina

    pp. 156–160 · DOI: 10.4103/pm.pm_280_19 · Published 11 February 2020

    Objectives: The objective of this study is to investigate the effect of blue, white, and red light for the growth and content of the four main flavones (baicalin, wogonoside, baicalein, and wogonin) in the callus tissue …

11. Article

    Ethanol Extract of Magnolia sieboldii Buds Ameliorated Esophageal Tissue Injury Induced by Gastric Acid Reflux in Rats via Regulating the Nuclear Factor‑κB Signaling Pathway

    Li Nan, Hyeon‑Hwa Nam, Jin‑Cheon Park, Byung‑Kil Choo

    pp. 161–168 · DOI: 10.4103/pm.pm_57_19 · Published 11 February 2020

    Objective: The objective is to investigate the anti‑inflammatory and protective effects of the ethanol extract of M. sieboldii buds (MsE) on RE. Materials and Methods: The different concentrations of MsE were used to det…

12. Article

    Cordyceps militaris Fraction Inhibits Angiogenesis of Hepatocellular Carcinoma in vitro and in vivo

    Zhiwei Li, Zhongyi Guo, Jianhua Zhu, Sixue Bi, Yuanyuan Luo, Rongmin Yu, Weijuan Huang, Liyan Song

    pp. 169–176 · DOI: 10.4103/pm.pm_347_19 · Published 11 February 2020

    Objectives: The objective of the study is to research the antiangiogenic activity of CMF in HCC cells and the underlying mechanism in vitro and in vivo. Materials and Methods: Transwell migration and invasion assays were…

13. Article

    Propionic Acid Abrogates the Deleterious Effects of Cerebral Ischemic Reperfusion Injury through Nuclear Factor‑κb Signaling in Mice

    Tiansong Yang, Yulin Wang, Chaoran Li, Yan Yang, Delong Wang, Jing Guo, Tianyu Shi, Yue Wang, Yuanyuan Qu, Qingshuang Wei, Chuwen Feng, Zhongren Sun

    pp. 177–182 · DOI: 10.4103/pm.pm_306_19 · Published 11 February 2020

    Background: Cerebral ischemia is caused due to insufficient blood flow to brain cells. This study evaluates the therapeutic effects of propionic acid (PA) on the abnormalities induced during the cerebral ischemic‑reperfu…

14. Article

    Skin‑Protective and Anti‑inflammatory Effects of Hibiscus syriacus L. (Mugunghwa): A Comparative Study of Five Parts of the Plant

    Jung‑Eun Yang, Sul Woong Park, Hien T. T. Ngo, Seul A. Seo, Eun Byeol Go, Jeong‑Seung Hwang, Eunson Hwang, Tae‑Hoo Yi

    pp. 183–191 · DOI: 10.4103/pm.pm_185_19 · Published 11 February 2020

    Aim: The skin barrier is vulnerable to internal and external elements. However, certain plant extracts have promise for protecting the skin. Hibiscus syriacus L. is a Korean national plant (mugunghwa) that has been tradi…

15. Article

    Red Seaweed (Eucheuma cottonii) Extract Promotes Human Keratinocyte Migration via p38 Mitogen‑Activated Protein Kinase Phosphorylation

    In Wook Kim, So Yeon Kim, Marianti Manggau, Harfina Finanda Anwar, Nyoun Soo Kwon, Kwang Jin Baek

    pp. 192–196 · DOI: 10.4103/pm.pm_203_19 · Published 11 February 2020

    Objectives: This study was performed to investigate the effects of EC extract on human keratinocyte migration. Materials and Methods: Cell migration was assessed using the scratch wound assay. Western blot analysis was p…

16. Article

    Vanillin an Active Constituent from Vanilla Bean Induces Apoptosis and Inhibits Proliferation in Human Colorectal Adenocarcinoma Cell Line

    Yandong Xie, Jingyu Zhang, Cheng Wang, Qinglin Fan, Yiling Zhang

    pp. 197–200 · DOI: 10.4103/pm.pm_235_19 · Published 11 February 2020

    Aim: The aim of the study was to investigate the antiproliferative and proapoptotic effects of vanillin (VL) an active constituent from Vanilla bean in colon cancer (human colorectal adenocarcinoma cell line [HT-29]) cel…

17. Article

    Constituents of Flavonoids from Tridax procumbens L. and Antioxidant Activity

    Hong-Xin Cui, Ling-Shuai Zhang, Hong-Guo Yan, Ke Yuan, Song-Heng Jin

    pp. 201–205 · DOI: 10.4103/pm.pm_229_19 · Published 11 February 2020

    Background: To study the chemical constituents and antioxidant activities of flavonoids in Tridax procumbens L. Materials and Methods: Diaion HP‑20, MCI‑Gel CHP‑20, Sephadex LH‑20, and silica gel column chromatography we…

18. Article

    Dietary Supplementation of Hemidesmus indicus and Swimming Exercise Attenuates Oxidative Stress in the Rat Brain

    Bhagyalakshmi Dundaiah, Anupama Sindhaghatta Kariyappa, Sowbhagya Ramachandregowda, Santosh Anand

    pp. 21–26 · DOI: 10.4103/pm.pm_239_19 · Published 11 February 2020

    Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant, but other species are less explored. Objective: To evaluate the anti…

19. Article

    Anti‑Inflammatory and Antinociceptive Activities of Salvia keerlii

    Roberto Serrano-Vega, Cuauhtemoc Pérez-González, Ángel Josabad Alonso-Castro, Juan Ramón Zapata-Morales

    pp. 27–33 · DOI: 10.4103/pm.pm_223_19 · Published 11 February 2020

    Objective: The objective is to study the determination of the anti‑inflammatory and antinociceptive properties and chemical composition of the chloroform extract of SAKE. Materials and Methods: The plant was defatted wit…

20. Article

    Enhancing Glucose Uptake by Astraeus odoratus and Astraeus asiaticus Extracts in L6 Myotubes

    Papawinee Phadannok, Alisa Naladta, Kusumarn Noipha, Natsajee Nualkaew

    pp. 34–42 · DOI: 10.4103/pm.pm_323_19 · Published 11 February 2020

    Objectives: The aim of this study is to describe the enhancing of glucose uptake and related mechanisms in vitro of the extracts from two Astraeus spp. Materials and Methods: The extracts of A. odoratus and A. asiaticus …

21. Article

    Role of Saccharum Granorum as a “Principal Drug” in a Traditional Chinese Medicine Formula against Chronic Atrophic Gastritis Rats

    Guohong Wang, XueMei Qin, Yuetao Liu

    pp. 43–50 · DOI: 10.4103/pm.pm_238_19 · Published 11 February 2020

    Background: Saccharum Granorum (YiTang) is a nutrient-rich food that has been used as traditional Chinese medicine (TCM). However, the mechanism responsible for its beneficial efficacy is poorly understood, especially fo…

22. Article

    Fucoxanthin Attenuates Behavior Deficits and Neuroinflammatory Response in 1‑Methyl‑4‑Phenyl‑1,2,3,6 ‑Tetrahydropyridine‑Induced Parkinson’s Disease in Mice

    Guoqing Sun, Tao Xin, Rui Zhang, Chengxiao Liu, Qi Pang

    pp. 51–56 · DOI: 10.4103/pm.pm_318_19 · Published 11 February 2020

    Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant used in traditional medicine for bone healing. Objective: The present…

23. Article

    The Effect of Phyllanthus debilis Methanolic Extract on DNA Methylation of TAC1 Gene in Colorectal Cancer Cell Line

    Siti Nur Dalila Mohd Zain, Wan Adnan Wan Omar

    pp. 57–60 · DOI: 10.4103/pm.pm_226_19 · Published 11 February 2020

    Background: In colorectal cancer, TAC1 was shown to be highly methylated in early carcinogenesis. Using HT29 cell line as a model of colorectal cancer, we postulated that Phyllanthus debilis methanolic extract could regu…

24. Article

    Bioactivity‑Guided Fractionation of Cymbopogon caesius (Ness) Stapf. Revealed Isoorientin as an Antihypertensive Agent

    Wei Lan, Hong Ping Zhang, Xian Da Gao

    pp. 61–67 · DOI: 10.4103/pm.pm_178_19 · Published 11 February 2020

    Objective: The aim of this study was to isolate the antihypertensive activity compounds from C. caesius (Ness) Stapf. Materials and Methods: Cymbopogon caesius (Ness) Stapf. was reflux extracted by EtOH, and the obtained…

25. Article

    Extraction, Purification, Content Analysis and Hypoglycemic Effect of Mulberry marc Anthocyanin

    Ji-Li Fang, Shan-Shan Jia, Yin Lin, Ke Yuan, Song-Heng Jin

    pp. 68–75 · DOI: 10.4103/pm.pm_169_19 · Published 11 February 2020

    Background: Mulberry marc (MM) which as a wasted residue contains many available resources and one of the valuable nutrients is anthocyanin. In this study, the extraction, purification, content analysis, and hypoglycemic…

26. Article

    In vivo Antimalarial Potential of Tinospora crispa Miers in Mice and Identification of the Bioactive Compound

    Wei Cai Lee, Roziahanim Mahmud, Shanmugapriya Perumal, Sabariah Ismail, Rusliza Basir

    pp. 76–82 · DOI: 10.4103/pm.pm_10_19 · Published 11 February 2020

    Objective: The present study investigated the potential of the crude methanol extract and antiparasitic fractions of T. crispa stem to exert antimalarial activity against Plasmodium berghei. Materials and Methods: The po…

27. Article

    Physiological Mechanism and Developmental Events in Differentiating Floral Buds of Sophora tonkinensis Gagnep

    Namuhan Chen, Zhu Qiao, Jianping Xu, Kunhua Wei, Minhui Li

    pp. 83–91 · DOI: 10.4103/pm.pm_174_19 · Published 11 February 2020

    Objective: We used paraffin sections and RNA-seq and then analyzed changes in physiological, biochemical, and endogenous hormones to examine floral bud differentiation. Materials and Methods: Buds were harvested in mid-M…

28. Article

    Evaluation of Lipopolysaccharide‑Induced Acute Lung Injury Attenuation in Mice by Glycyrrhiza glabra

    Ye Shen, Nannan Han, Huan Chen, Meiqi Zhang, Wenwei Cai

    pp. 92–98 · DOI: 10.4103/pm.pm_189_19 · Published 11 February 2020

    Objective: The medicinal importance of Glycyrrhiza glabra is well reported in Asian folk core medicine. In the current study, we have investigated the treatment effects of ethanolic extract of G. glabra in acute lung inj…

29. Article

    Comparative Study of Ultra‑High‑Performance Supercritical Fluid Chromatography and Ultra‑High‑Performance Liquid Chromatography to Simultaneous Determination of Ten Components in Radix hedysari

    Bo Wang, Xiao‑Hua Liu, Zhi‑Yuan Xue, Xiu‑Yan Yang, Yao‑Yao Fang, Shi‑Lan Feng

    pp. 99–110 · DOI: 10.4103/pm.pm_241_19 · Published 11 February 2020

    Objective: This study intends to establish a high‑throughput method for simultaneous determination of ten compounds in RH by UHPSFC and to develop a standardized method to comprehensively evaluate the quality of RH sampl…