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    A Rapid and Efficient Approach Based on Ultra‑High Liquid Chromatography Coupled with Mass Spectrometry for Identification in vitro and in vivo Constituents from Shizao Decoction

    Yu-Mei Wang1, Qi Liu1★, Wen-Hao Fu1, Ai-Hua Zhang2★★ Corresponding author

    1. 1Qiqihar Academy of Medical Sciences, The Research Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
    2. 2National Chinmedomics Research Center, Sino‑America Chinmedomics Technology Collaboration Center, National Traditional Chinese Medicine Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Heilongjiang University of Chinese Medicine, Harbin, China.

    CORRESPONDENCE

    Qi Liu

    Qiqihar Academy of Medical Sciences, The Research Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar, Heilongjiang, China.

    liuqi_hlj@163.com

    Received: 07-08-2019; Revised: 04-09-2019; Accepted: 12-09-2019.

    Volume 16, Issue 67 · pp. 148–155 · PUBLISHED 11 February 2020 · DOI: 10.4103/pm.pm_329_19

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant used in traditional medicine for bone healing. Objective: The present study was aimed to evaluate the anti-inflammatory and analgesic activities of the methanolic extract of <em>Cissus quadrangularis</em> (MECQ) in experimental animal models. Materials and Methods: The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema model, and analgesic activity was evaluated using acetic acid-induced writhing and hot plate methods in mice. Results: MECQ at doses of 200 and 400 mg/kg showed significant (P < 0.01) anti-inflammatory activity in carrageenan-induced rat paw edema. In analgesic models, MECQ exhibited significant (P < 0.01) reduction in the number of writhes in acetic acid-induced writhing test and increased the reaction time in hot plate method. Conclusion: The results suggest that MECQ possesses significant anti-inflammatory and analgesic activities, which supports its traditional use.

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      Wang, Y., Liu, Q., Fu, W., & Zhang, A. (2020). A Rapid and Efficient Approach Based on Ultra‑High Liquid Chromatography Coupled with Mass Spectrometry for Identification in vitro and in vivo Constituents from Shizao Decoction. Pharmacognosy Magazine, 16(67), 148–155. https://doi.org/10.4103/pm.pm_329_19