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    Fucoxanthin Attenuates Behavior Deficits and Neuroinflammatory Response in 1‑Methyl‑4‑Phenyl‑1,2,3,6 ‑Tetrahydropyridine‑Induced Parkinson’s Disease in Mice

    Guoqing Sun1, Tao Xin2, Rui Zhang2, Chengxiao Liu1, Qi Pang2★★ Corresponding author

    1. 1Departments of Anesthesiology, Hospital Affiliated to Shandong University, Huaiyin District, Jinan, Shandong Province, PR China.
    2. 2Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Huaiyin District, Jinan, Shandong Province, PR, China.

    CORRESPONDENCE

    Qi Pang

    Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Huaiyin District, Jinan, Shandong Province, PR, China.

    drpangqi@sina.com

    Received: 19-07-2019; Revised: 14-08-2019; Accepted: 12-11-2019.

    Volume 16, Issue 67 · pp. 51–56 · PUBLISHED 11 February 2020 · DOI: 10.4103/pm.pm_318_19

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant used in traditional medicine for bone healing. Objective: The present study was aimed to evaluate the anti-inflammatory and analgesic activities of the methanolic extract of <em>Cissus quadrangularis</em> (MECQ) in experimental animal models. Materials and Methods: The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema model, and analgesic activity was assessed using acetic acid-induced writhing and tail-flick methods in mice. Results: MECQ at doses of 200 and 400 mg/kg showed significant (P < 0.01) anti-inflammatory activity in carrageenan-induced rat paw edema. In analgesic models, MECQ exhibited significant (P < 0.01) reduction in the number of writhes in acetic acid-induced writhing test and increased the reaction time in tail-flick method. Conclusion: The results suggest that MECQ possesses significant anti-inflammatory and analgesic activities, which supports its traditional use.

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      Sun, G., Xin, T., Zhang, R., Liu, C., & Pang, Q. (2020). Fucoxanthin Attenuates Behavior Deficits and Neuroinflammatory Response in 1‑Methyl‑4‑Phenyl‑1,2,3,6 ‑Tetrahydropyridine‑Induced Parkinson’s Disease in Mice. Pharmacognosy Magazine, 16(67), 51–56. https://doi.org/10.4103/pm.pm_318_19