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    Pharmacognosy MagazineNOW IN
    Article

    Antiobesity Effects of Lycii Fructus in High‑Fat Diet/FructoseInduced Obese Rats

    Junchao Yuan2, Runfen Du3, Zhuang Kang2, Ben Niu2, Opeyemi Joshua Olatunji4, Yan Wang2★, Heng Su2★★ Corresponding author

    1. 1Department of Endocrinology, The First People’s Hospital of Yunnan Province.
    2. 2Department of Geriatrics, The Third People’s Hospital of Yunnan Province, Kunming, China.
    3. 3Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, 90110, Thailand.

    CORRESPONDENCE

    Yan Wang

    Department of Geriatrics, The Third People’s Hospital of Yunnan Province, Kunming, China.

    kaixinxiaaa@sina.com

    Received: 26-06-2019; Revised: 30-09-2019.

    Volume 16, Issue 68S · pp. S87–S92 · PUBLISHED 31 March 2020 · DOI: 10.4103/pm.pm_276_19

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: This study was aimed at investigating the effect of the ethyl acetate extract from Lycii fructus (ETLF) against high‑fat diet (HFD)/fructose‑induced obesity in rats. Materials and Methods: Obesity was induced in rats by feeding them with HFD and 15% fructose for 8 weeks, while the animals in ETLF groups were administered with 100 and 400 mg/kg of ETLF once daily from the 5th to the 8th week. Results: ETLF displayed antiobesity by significantly reducing body weight gain, serum lipid levels as well as alleviating increased serum insulin and glucose levels. In addition, ETLF treatment when compared to the HFD/fructose fed group significantly alleviated oxidative stress and inflammation by reducing malondialdehyde, tumor necrosis factor alpha, interleukin 1 beta (IL‑1 β) and IL‑6 levels as well as enhancing the activities of superoxide dismutase, catalase, and glutathione peroxidase. Conclusion: Thus, these results portrayed that ETLF had protective effects against metabolic disorders induced by HFD/fructose through its antioxidant, anti‑inflammatory, and antihyperlipidemic activities.

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      Yuan, J., Du, R., Kang, Z., Niu, B., Olatunji, O. J., Wang, Y., & Su, H. (2020). Antiobesity Effects of Lycii Fructus in High‑Fat Diet/FructoseInduced Obese Rats. Pharmacognosy Magazine, 16(68S), S87–S92. https://doi.org/10.4103/pm.pm_276_19