Fucoxanthin Averts Isoprenaline Hydrochloride‑Induced Myocardial Infarction in Rats

ABSTRACT

Objective: In this scientific investigation, we planned to investigate the curative effectual of fucoxanthin on isoprenaline hydrochloride provoked myocardial infarction on the experimental rats. Materials and Methods: Healthy Wistar albino rats were grouped into control, fucoxanthin alone, myocardial infarction induced, and myocardial infarction induced pretreated with fucoxanthin. The control rats were treated with a standard food diet, whereas fucoxanthin alone group rats were treated with 50 mg/kg/bwt of fucoxanthin along with standard diet. Myocardial infarction‑induced groups were treated with 85 mg/kg/bwt of isoprenaline hydrochloride to induce myocardial infarction on the 29th and 30th days of the treatment period. Group IV rats were pretreated with 50 mg/kg/bwt of fucoxanthin from day 1 of experiment and on the 29th and 30th days of treatment period treated with 85 mg/ kg/bwt of isoprenaline hydrochloride to induce myocardial infarction. Results: The fucoxanthin possessed effective cardioprotective activity in mycardiac infarction‑induced rats. Fucoxanthin treatment reduced the statuses of cardiac troponin T and cardiac troponin I on myocardial infarction provoked rats; also, it exhibited the reduced Thiobarbituric acid reactive substances (TBARS) level in the rats. The antioxidant status such as superoxide dismutase, catalase, and glutathione peroxidase was extensively elevated in the myocardial infarction‑induced fucoxanthin pretreated rats. Myocardial infarction‑induced fucoxanthin pretreated rats shows decreased statuses of Na+/K+ ATPase and increase on the Na+/ K+ ATPase level. Conclusion: Our results confirmed that fucoxanthin is a potent cardioprotective drug which increases the antioxidant levels and decreases the oxidative stress and inflammation during myocardial infarction.

KEYWORDS

• Antioxidant
• fucoxanthin
• in vivo
• inflammatory proteins
• isoprenaline
• myocardial infarction

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• DOI10.4103/pm.pm_357_19Copy

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