Volume 16, Issue 69

15 June 2020 · pp. 207–447 · 35 articles

Volume: 16
Issue: 69
Published: 15 June 2020
Pages: 207–447
Articles: 35
Sections: 1
ISSN: ISSN: Print - 0973-1296, Online - 0976-4062
Journal: Pharmacogn. Mag.

Original Article

In this issue

Original Article

Article
Effect of Phloretin Treatment Ameliorated the Cisplatin‑Induced Nephrotoxicity and Oxidative Stress in Experimental Rats
Yan Zhao, Wei Dai
pp. 207–213 · DOI: 10.4103/pm.pm_346_19 · Published 15 June 2020
Background: The cisplatin is one of the widely employed platinum‑based drugs as the chemotherapeutic substance for the treatment of various cancers such as bladder cancer, prostate cancer, cervix cancer, and lung cancer.…
Article
Fucoxanthin Averts Isoprenaline Hydrochloride‑Induced Myocardial Infarction in Rats
Fang Wang, Hao Zhang, Guo Lv, Zhenguo Liu, Xin Zheng, Xianjun Wu
pp. 214–220 · DOI: 10.4103/pm.pm_357_19 · Published 15 June 2020
Objective: In this scientific investigation, we planned to investigate the curative effectual of fucoxanthin on isoprenaline hydrochloride provoked myocardial infarction on the experimental rats. Materials and Methods: H…
Article
Identification of Anticancer Compounds from Linum usitatissimum seed Extract and their Effect on HeLa Cells
Anitha Joseph, Sriram Sridharan, Sampathkumar Palanisamy, Sivakumar Ramalingam, Renuka Saravanan
pp. 221–226 · DOI: 10.4103/pm.pm_341_19 · Published 15 June 2020
Aim: The aim of the study is to analyze the phytoconstituents and to determine the anticancer potential of Linum usitatissimum seed against Human cervical cancer cell line is the correct expansion (HeLa). Materials and M…
Article
Extraction, Isolation and Identification of Kaempferol 3,7 – Diglucoside in the Leaf Extracts of Evolvulus alsinoides (Linn.) and its Inhibition Potency against α‑Amylase, α‑Glucosidase, Acetylcholinesterase and Amyloid Aggregation
Pavithra Mettupalayam Kaliyannan Sundaramoorthy, Kannan Kilavan Packiam
pp. 227–234 · DOI: 10.4103/pm.pm_583_19 · Published 15 June 2020
Objectives: To report the enzyme inhibitory potency of the plant extract and to isolate the compound of significant impact. Materials and Methods: The plant extracts were obtained by serial exhaustive extraction and succ…
Article
Fucoxanthin Attenuates the Lipopolysaccharide‑induced Sepsis and Acute Lung Injury through the Inactivation of Nuclear Factor‑Kappa B Signaling Pathway
Yun Xiao, Chun Yang, Minna Dong, Jinfeng Zhao, Xia Wang, Mingyao Xiao
pp. 235–241 · DOI: 10.4103/pm.pm_487_19 · Published 15 June 2020
Objectives: The acute lung injury was a very severe health consequence and it was allied with the highest morbidity as well as mortality rate among the peoples. The acute lung injury can be induced through the various di…
Article
Protective Effect of Fucoxanthin on Ovariectomy‑Induced Osteoporosis in Rats
Lichun Guo, Minyan Dang, Qichun Song, Wenzhi Zhang, Bing Li
pp. 242–249 · DOI: 10.4103/pm.pm_340_19 · Published 15 June 2020
Objective: We planned to investigate the therapeutic effect of fucoxanthin on ovariectomy‑stimulated osteoporosis in experimental rats. Hence, the study is conducted to evaluate the protective effect of fucoxanthin again…
Article
Protective Effect of Adropin against High Fat Diet‑induced Obese Diabetic Wistar Rats via Nuclear Factor Erythroid 2‑related Factor 2 Pathway
Fang Luo, Qing‑Chu Li, Feng‑Jiao Zhang, Lei Li, Li‑Ge Song, Yu Mao, Jing Li, Hong‑Mei Liu, Feng‑Li Li, Ling‑Yu Xu
pp. 250–257 · DOI: 10.4103/pm.pm_434_19 · Published 15 June 2020
Background: The genus Cissus (Vitaceae) is known for its medicinal properties. Cissus quadrangularis is a well-known medicinal plant, but other species are less explored. Objective: To evaluate the anti…
Article
Exploration of Aurora B and Cyclin‑Dependent Kinase 4 Inhibitors Isolated from Scorzonera tortuosissima Boiss. and their Docking Studies
Ehab M. Mostafa
pp. 258–263 · DOI: 10.4103/pm.pm_1_20 · Published 15 June 2020
Objectives: The objective was to study the cytotoxicity, kinase inhibitory activity, and docking of the isolated aglycones. Materials and Methods: Ultraviolet, high‑performance liquid chromatography (LC), nuclear magneti…
Article
Bioassay‑guided Isolation, Identification, and Evaluation of Anti‑inflammatory Activity of β‑Boswellic Alcohol and 3‑O‑Acetyl‑11‑hydroxy‑β‑Boswellic Acid from the Leaves of Boswellia serrata
Tarun Sharma, Snehasis Jana
pp. 264–273 · DOI: 10.4103/pm.pm_17_20 · Published 15 June 2020
Objectives: The goal of this research plan was the isolation and purification of most active compounds from the leaves of BS via bioassay‑guided fractionation based on anti‑inflammatory activity. Materials and Methods: T…
Article
Screening of Potential Inhibitors against Flotillin‑1 as Therapeutics for Alzheimer’s Disease
Amit Chaudhary, Ashutosh Mani
pp. 274–281 · DOI: 10.4103/pm.pm_514_19 · Published 15 June 2020
Objective: This study aims to screen the potential inhibitors against FLOT1 as therapeutics for AD. Materials and Methodology: In this work, protein–protein interactions, tertiary structure prediction, molecular docking,…
Article
Charantin Relieves Pain by Inhibiting Pro‑Inflammatory Cytokine Induction
Jaewon Shim, Jae Goo Kim, Eun Yeong Lim, Yun Tai Kim
pp. 282–287 · DOI: 10.4103/pm.pm_348_19 · Published 11 June 2020
Objectives: Because there have been little reports on charantin’s role as an analgesic, we evaluated its pain relief effect to determine if it could be a novel pain killer candidate. Materials and Methods: We established…
Article
Identification and Quantification Bioactive Compounds on Liquid Extract of Capsicum chinense Jacq. Biquinho variety: Standardization and Quality Control is Frontier to Acceptance of Herbal Products on Market
Lucélia de Sousa Brito, Aline Neves Pereira, Emannuel Ítalo Alves Campos, Andressa Tuane Santana Paz, Mariana Cristina de Morais, Leonardo Luiz Borges, Edemilson Cardoso da Conceição
pp. 288–293 · DOI: 10.4103/pm.pm_303_19 · Published 15 June 2020
Objectives: The aim of the present study was to develop and characterize the liquid extract of Capsicum chinense Jacq. Biquinho variety standardized in capsanthin. Materials and Methods: The liquid extract of the pepper …
Article
Dendrobium officinale Kimura et Migo Improved Dry Eye Symptoms via Promoting Tear Production in an Experimental Dry Eye Rat Model
Qiang Zeng, Wing‑Sum Siu, Chun‑Hay Ko, Chun‑Wai Wong, Clara Bik‑San Lau, Zheng‑Zhi Wu, Jiang‑Miao Hu, Ping‑Chung Leung
pp. 294–302 · DOI: 10.4103/pm.pm_435_19 · Published 15 June 2020
Background: The genus Cissus (Vitaceae) is known for its medicinal properties. Cissus quadrangularis is the most studied species, but other species like Cissus vitiginea L. also possess pharmac…
Article
D‑Carvone Attenuates Biochemical and Molecular Expression via Oncogenic Signaling in Aryl Hydrocarbon‑Induced Hamster Mucosal Carcinogenesis
Jingxuan Wang, Yan Hu, Yifan Wang, Yingshun Yang, Song Li, Yujiao Hou, Zhizheng Zhuang, Fan Wu
pp. 303–310 · DOI: 10.4103/pm.pm_302_19 · Published 15 June 2020
Background: Chemo prevention through nutritional constituents has appeared as an innovative methodology to control the oral cancer incidence. The main target of this research exists to explore the chemopreventive effect …
Article
Fucoxanthin Inhibits Cell Proliferation and Stimulates Apoptosis through Downregulation of PI3K/AKT/mTOR Signaling Pathway in Human Ovarian Cancer Cells
Yan Li, Leisi Tao, Lei Bao, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Jianying Cui
pp. 311–316 · DOI: 10.4103/pm.pm_330_19 · Published 15 June 2020
Background: Fucoxanthin is rich in seaweed and considered the most efficient anticancer drug because of its powerful antioxidant properties. The aim of this study was to elucidate the role of fucoxanthin on apoptosis via…
Article
Phytochemical Analysis, Antipropulsive and Antilymphoma Activities of Leaves Extract of Annona cherimola Miller
Fernando Calzada, Miguel Valdés, Verenice Itzel Merlin, Claudia Velázquez, Elizabeth Barbosa, Marco Chávez‑Soto, Emmanuel Pina‑Jiménez, Rosa Maria Ordoñez‑Razo, Normand García‑Hernández
pp. 317–320 · DOI: 10.4103/pm.pm_462_19 · Published 15 June 2020
Objectives: The present work reports the identification of flavonol glycosides present in the ethanol crude extract using high‑performance liquid chromatography with diode array detection (HPLC‑DAD). Materials and Method…
Article
Evaluation of Anti-inflammatory and Antioxidant Activities of Cissus quadrangularis Stem Extract
Ahmed Al-Ghamdi, Mohammed Al-Saeed
pp. 321–328 · DOI: 10.4103/pm.pm_222_19 · Published 15 June 2020
Background: The genus Cissus (Vitaceae) is known for its medicinal properties. Cissus quadrangularis L. is a well-known medicinal plant used in traditional medicine for bone healing. Objective: The pres…
Article
Neuroprotective Compounds from the Embryo of Nelumbo nucifera Seeds
Jin Bae Weon, Choong Je Ma
pp. 329–335 · DOI: 10.4103/pm.pm_613_18 · Published 15 June 2020
Objectives: The present study was designed for the purpose of evaluating the neuroprotective activity of compounds isolated from the embryo of N. nucifera seeds on glutamate‑induced cell death in HT‑22 cells. Materials a…
Article
Anti-inflammatory and Analgesic Activities of Cissus quadrangularis L. Methanolic Extract in Experimental Animal Models
Eunson Hwang, Sul Woong Park, Jung‑Eun Yang
pp. 336–340 · DOI: 10.4103/pm.pm_326_19 · Published 15 June 2020
Aim: In this study, the skin-protective effects of two geographical types of EBN (EBN‑A and EBN‑B) were investigated. Materials and Methods: The anti-aging effect was assessed in ultraviolet B (UVB)‑irradiated normal hum…
Article
Effects of the Japanese Kampo Medicine, Rikkunshito, on Gastrointestinal Motility Functions
Minwoo Hwang, Donghun Han, Byung Joo Kim
pp. 343–346 · DOI: 10.4103/pm.pm_370_19 · Published 15 June 2020
Objectives: The objective was to find the effect of GI motility with Rikkunshito. Materials and Methods: The prokinetic effect of Rikkunshito was investigated by studying the gastric emptying (GE) and intestinal transit …
Article
Study on the Characteristics of Pharmacokinetics of Different Doses of Gastrodin in Mice
Xinyu Wang, Xin Liu, Xing Wang, Yu Dong
pp. 347–352 · DOI: 10.4103/pm.pm_307_19 · Published 15 June 2020
Background: The genus Cissus (Vitaceae) is known for its medicinal properties. Cissus quadrangularis is a well-known medicinal plant used in traditional medicine for bone healing. Objective: The present…
Article
Comparative Analysis of the Chemical Constituents from the Tuberous Root and Stem of Pueraria candollei var. mirifica and Evaluation of their Estrogenic Activity
Witsarut Kraithong, Wipawee Juengsanguanpornsuk, Supaluk Krittanai, Gorawit Yusakul, Waraporn Putalun
pp. 353–358 · DOI: 10.4103/pm.pm_442_19 · Published 15 June 2020
Background: Pueraria candollei var. mirifica (PC) is a tuberous plant enriched with bioactive phytoestrogens. PC is currently high demanded in the global markets as dietary supplement products, which resulted in a shorta…
Article
Evaluation of Wound Healing Potential of Ascorbic Acid, Castor Oil, and Gum Tragacanth Formulation in Murine Excisional Wound Model
Ajay K. Sharma, Sandeep Kumar Shukla, Aman Kalonia, Priyanka Shaw, M. H. Yashavarddhan, Kailash Manda
pp. 359–368 · DOI: 10.4103/pm.pm_440_19 · Published 15 June 2020
Objectives: The objective of this study was to evaluate the potential of ascorbic acid, castor oil, and gum tragacanth formulation, as an effective wound healing composition. Materials and Methods: A formulation containi…
Article
Tillandsia usneoides Protects RINm5F Cells from Streptozotocin-
Induced Apoptosis, Stimulates Insulin Secretion Janet Alejandra Espejel‑Nava, Francisco Alarcon‑Aguilar, María del Carmen Escobar‑Villanueva, Alejandra Contreras‑Ramos, Miguel Cruz, Elisa Vega‑Avila, Clara Ortega‑Camarillo
pp. 369–374 · DOI: 10.4103/pm.pm_277_19 · Published 15 June 2020
Objectives: The aim of this research was to determine the hypoglycemic effect of an aqueous extract from T. usneoides in normal and diabetic mice as well as to evaluate the participation of insulin in this effect using a…
Article
Comparison of the Content of Flavonoids, Total Phenols, and Carotenoids and Antioxidant Activity in Guang Citri reticulatae Pericarpium during the Aging Time
Guangning Wang, Shuwen Chen, Guangshan Gu, Jieqing Qiu, Yuanling Chen, Zhen Jia, Hongmei Tang
pp. 375–381 · DOI: 10.4103/pm.pm_295_19 · Published 15 June 2020
Objectives: The objective of this study was to compare the content of flavonoids, total phenols, and carotenoids and antioxidant activity in GCRP during the aging time and analyze the correlations of the data. Materials …
Article
Antiviral Assessments of Honeybee (Apis mellifera L.) Venom
Sang Mi Han, Se Gun Kim, Hyo Young Kim, Hong Min Choi, Hyo Jung Moon, Soon Ok Woo, Sok Cheon Pak
pp. 382–385 · DOI: 10.4103/pm.pm_337_19 · Published 15 June 2020
Background: The poultry industry has long been challenged by avian influenza which causes significant economic loss due to decreased egg production and quality. In addition, the notable ability of influenza viruses to de…
Article
Effect of Exogenous Ca2+ on Growth and Accumulation of Major Components in Tissue Culture Seedlings of Sophora tonkinensis Gagnep
Ying Liang, Lin Xuan Li, Jin Yuan Cai, Chuan Hua Deng, Shuang Shuang Qin, Ming Jie Li, Kun Hua Wei, Zhong Yi Zhang
pp. 386–392 · DOI: 10.4103/pm.pm_362_19 · Published 15 June 2020
Objectives: The effects of exogenous Ca2+ on plant height, stem diameter, enzyme activity, endogenous hormone content, and other traits of S. tonkinensis, and accumulation of matrine and oxymatrine in its active constitu…
Article
Harnessing Multiplex Polymerase Chain Reaction Assay for Convenient and Simultaneous Differentiation of Testudinis Carapax et Plastrum from Trionycis Carapax
Zhaoqun Jiao, Liqun Chen, Lijuan Xia, Yaya Yang, Yang Zheng, Hongxia Chen, Liwei Wang, Pingtian Yu, Yuping Shen
pp. 393–399 · DOI: 10.4103/pm.pm_198_19 · Published 15 June 2020
Objective: The objective of the study was to develop a multiplex polymerase chain reaction (PCR) approach to simultaneously differentiate five Chelonia species and identify adulteration of two natural products. Materials…
Article
Clinacanthus nutans Aqueous Extract Suppresses the Release of Histamine and β‑Hexosaminidase in in-vitro Model of IgE‑Mediated Mast Cell Degranulation
Audrey Siew Foong Kow, Lai Yen Fong, Leng Wei Khoo, Ji Wei Tan, Ming-Tatt Lee, Daud Ahmad Israf, Faridah Abas, Khozirah Shaari, Chau Ling Tham
pp. 400–408 · DOI: 10.4103/pm.pm_221_19 · Published 15 June 2020
Background: The genus Crotalaria (Fabaceae) is known for its diverse pharmacological activities. Objective: The present study was aimed to evaluate the anti-inflammatory and analgesic activities of the methanoli…
Article
A New Method for Purifying Brazilin from Lignum Sappan – Cytotoxic and Anti‑Proliferative Effects in Cell Lines and Improved Survival in Mice Bearing Urinary Bladder Carcinoma
Xihua Yang, Lili Zhao, Xuebing Han, Lixia Chen, Yongming Yang, Jing Wang, Lei Yan, Tingting Zhang, Huanhu Zhang
pp. 409–415 · DOI: 10.4103/pm.pm_308_19 · Published 15 June 2020
Objectives: The present study describes a methodology for extracting and obtaining high purity brazilin from Lignum sappan and evaluates its effects on urinary bladder carcinoma, in vitro and in vivo. Materials and Metho…
Article
Antiprotease Activity of Indigenous Medicinal Plants against Pakistani Echis carinatus Venom
Nazia Aslam, Tariq Javed, Sofia Khalid, Nusrat Shaheen, Syeda Fatima, Muhammad Latif, Khurram Afzal, Samina Afzal, Khizar Abbas, Muhammad Arfat Yameen, Yasser M. S. A. Al-Kharaman, Muhammad Imran Amirzada, Ryan J. R. McCleary, Albert A. Rizvanov, Muhammad Hassham Hassan Bin Asad
pp. 416–421 · DOI: 10.4103/pm.pm_355_19 · Published 15 June 2020
Objectives: This study was conducted to investigate the inhibitory potential of extracts from Pakistani medicinal plants against protease enzyme abundant in Echis carinatus venom. Materials and Methods: Organic extracts …
Article
Apoptosis Induction and Reactive Oxygen Species Generation by Artemisia absinthium L. Leaf Extract in MCF‑7 Breast Carcinoma Cells
Long Li, Jin Wang, Shan Miao, Shanbo Ma, Xiaopeng Shi, Aidong Wen
pp. 422–427 · DOI: 10.4103/pm.pm_14_20 · Published 15 June 2020
Background: Breast cancer is the commonly occurring cancer among women in both high‑resource and low‑resource settings, and the primary cause of death among women globally owing to suboptimal anticancer chemotherapy. Thi…
Article
Anti‑Inflammatory Effect of Bougainvillea × buttiana (Var. Orange) Extract in Experimental Bothrops jararaca Envenomation
Rodolfo Abarca‑Vargas, Lluvia Arteaga Figueroa, Ronaldo Zucatelli Mendonça, Vera L. Petricevich
pp. 428–434 · DOI: 10.4103/pm.pm_372_19 · Published 15 June 2020
Objective: In this study, the anti‑inflammatory effect of B. x buttiana orange extract (BxbO) was evaluated on edema formation, cytokine production, and lethality in mice in response to venom of Bothrops jararaca (VBj) s…
Article
Formononetin Induces Apoptosis of PC‑3 Human Prostate Cancer Cells via Regulating Long Noncoding RNA H19 and the Mitochondrial Apoptosis Pathway
Ruyue Wang, Kaiguo Li, Zhaodi Xie, Bailei Wang, Yan Dai, Jian Chen, Yu Ye
pp. 435–440 · DOI: 10.4103/pm.pm_320_19 · Published 15 June 2020
Objectives: We investigated the toxic effects and potential molecular mechanism of formononetin in PC‑3 prostate cancer cells to further understand the pharmacological effects of formononetin and provide more references …
Article
Cloning, Prokaryotic Expression, and Enzyme Activity of a UDP‑Glucose Flavonoid 3‑O‑Glycosyltransferase from Mulberry (Morus alba L.) Leaves
Xiaofeng Yu, Jia Liu, Jingqiong Wan, Li Zhao, Yaran Liu, Yuan Wei, Zhen Ouyang
pp. 441–447 · DOI: 10.4103/pm.pm_396_19 · Published 15 June 2020
Objectives: In this article, MaUFGT, a cDNA encoding the UFGT from mulberry leaves, was cloned, codon optimized, and expressed in Escherichia coli to study its effect in vitro. Materials and Methods: Mulberry UDP- Glucos…