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    Article

    New Phytopharmaceutical Formulations: Development and Characterization of Tablets Containing the Aerial Part of the Plant Pulverized and the Soft Extract from Bidens pilosa Standardized on Rutin

    Aline Neves Pereira1★, Mariana Cristina de Morais1, Nathália Olívia de Sousa Garcia1, Nathalia Pedroso Barbosa1★ Corresponding author

    1. 1Maythsulene Inácio de Sousa Oliveira, Emannuel Ítalo Alves Campos, Edemilson Cardoso da Conceição Bioproducts Research, Development and Innovation Department, Faculty of Pharmacy, Federal University of Goiás, Goiânia, GO, Brazil.

    CORRESPONDENCE

    Aline Neves Pereira

    Maythsulene Inácio de Sousa Oliveira, Emannuel Ítalo Alves Campos, Edemilson Cardoso da Conceição Bioproducts Research, Development and Innovation Department, Faculty of Pharmacy, Federal University of Goiás, Goiânia, GO, Brazil.

    aline.nevesnp@gmail.com

    Received: 25-08-2019; Revised: 04-10-2019; Accepted: 09-01-2020.

    Volume 16, Issue 70S · pp. S246–S254 · PUBLISHED 28 August 2020 · DOI: 10.4103/pm.pm_374_19

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objective: The aim of the present study was to obtain oral solid dosage forms (tablets) containing the aerial part of the plant pulverized and soft extract of B. pilosa standardized on rutin, as well as the validation of an analytical method for determination of the rutin content of the powder, soft extract and of the tablets. Materials and Methods: The liquid extract from B. pilosa was obtained by percolation and concentrated until it became a soft extract. An analytical method, by high‑performance liquid chromatography, was validated for the quantification of rutin in the soft extract. Tablets containing the aerial part of the plant pulverized and the soft extract of B. pilosa quantified on rutin was obtained and characterized. After, the method for quantification of rutin on the tablets was covalidated. Results: The rutin content in the raw material was 0.71% (m/m), while in the soft extract was 7.29% (m/m). The dissolution efficiency of the tablets was significantly higher, for both formulations in the pH 6.8 medium compared to medium with pH 1.2. Pilot tablets PH and SE presented results above of that recommended after 120 days. Conclusion: Pilot tablets SE, with soft extract, presented higher content of rutin than pilot tablets PH, with powder of the aerial part from raw material. This new phytopharmaceuticals formulation proved to be promising to be a strategy to carry out the active principles of B. pilosa.

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      Pereira, A. N., Morais, M. C. D., Garcia, N. O. D. S., & Barbosa, N. P. (2020). New Phytopharmaceutical Formulations: Development and Characterization of Tablets Containing the Aerial Part of the Plant Pulverized and the Soft Extract from Bidens pilosa Standardized on Rutin. Pharmacognosy Magazine, 16(70S), S246–S254. https://doi.org/10.4103/pm.pm_374_19