Volume 16, Issue 70S

Original Article

1. Article

   Naringenin Sensitizes Lung Cancer NCI‑H23 Cells to Radiation by Downregulation of Akt Expression and Metastasis while Promoting Apoptosis

   Taranga Jyoti Baruah, Kimrose Hauneihkim, Lakhon Kma

   pp. S229–S235 · DOI: 10.4103/pm.pm_535_19 · Published 28 August 2020

   Objectives: The objective of the study was to check for the ability of NGN to promote radiosensitization of the lung cancer cell line – NCI‑H23 (H23). Materials and Methods: 3‑(4,5-dimethylthiazol‑2‑yl)‑2,5‑diphenyltetra…

2. Article

   Polyphenol‑Enriched Fraction and the Compounds Isolated from Garcinia indica Fruits Ameliorate Obesity through Suppression of Digestive Enzymes and Oxidative Stress

   Kavita Munjal, Sheeraz Ahmad, Apeksha Gupta, Abdul Haye, Saima Amin, Showkat R. Mir

   pp. S236–S245 · DOI: 10.4103/pm.pm_587_19 · Published 28 August 2020

   Objective: To explore the anti-obesity effect of polyphenol‑enriched fraction and the compounds isolated from G. indica fruits through the inhibition of key metabolizing enzymes and oxidative stress. Materials and Method…

3. Article

   New Phytopharmaceutical Formulations: Development and Characterization of Tablets Containing the Aerial Part of the Plant Pulverized and the Soft Extract from Bidens pilosa Standardized on Rutin

   Aline Neves Pereira, Mariana Cristina de Morais, Nathália Olívia de Sousa Garcia, Nathalia Pedroso Barbosa

   pp. S246–S254 · DOI: 10.4103/pm.pm_374_19 · Published 28 August 2020

   Objective: The aim of the present study was to obtain oral solid dosage forms (tablets) containing the aerial part of the plant pulverized and soft extract of B. pilosa standardized on rutin, as well as the validation of…

4. Article

   Neurocognitive Investigation of Morinda tinctoria against Amyloid Beta‑Induced Oxidative Insult and Cognitive Impairment in Albino Mice: A Phytotherapeutic Approach

   D. Sivaraman, M. Arun, R. Kannan, P. S. Pradeep, P. Muralidharan

   pp. S255–S262 · DOI: 10.4103/pm.pm_284_19 · Published 28 August 2020

   Objectives: The objective of the present research is to investigate the neurocognitive enhancing potential of MT against amyloid beta (Aβ) (25–35)‑induced memory dysfunction in mice. Materials and Methods: Animals were p…

5. Article

   Turcuron: A Standardized Bisacurone‑Rich Turmeric Rhizome Extract for the Prevention and Treatment of Hangover and Alcohol‑Induced Liver Injury in Rats

   H. V. Sudeep, K. Venkatakrishna, K. Sundeep, H. S. Vasavi, Amritha Raj, S. Chandrappa, K. Shyamprasad

   pp. S263–S271 · DOI: 10.4103/pm.pm_32_20 · Published 28 August 2020

   Objectives: The present work investigated the hepatoprotective effects of Turcuron, a first-of-its-kind extract from Curcuma longa tubers containing 8% bisacurone, with respect to alcohol‑induced liver injury in rats. We…

6. Article

   In vitro Antioxidant and Anti-inflammatory Activities of the Methanolic Extract of the Leaves of Cissus quadrangularis L.

   Fernando Calzada, Miguel Valdés, Elizabeth Barbosa, Claudia Velázquez, Elihú Bautista

   pp. S272–S275 · DOI: 10.4103/pm.pm_540_19 · Published 28 August 2020

   Objectives: The present study was undertaken to evaluate a possible antipropulsive activity of the dichloromethane crude extract and two sesquiterpene lactones from Decachaeta incompta. Materials and Methods: Charcoal‑gu…

7. Article

   In vitro Antiplasmodium and Chloroquine Resistance Reversal Effects of Mangostin

   Zaid Osamah Ibraheem, Roslaini Abdul Majid, Ashraf Alapid, Hasidah Mohammad Sedik, M. N. Sabariah, Mohammad Faruq, Voon Kin Chin, Rusliza Basir

   pp. S276–S283 · DOI: 10.4103/pm.pm_510_19 · Published 28 August 2020

   Background: Chloroquine (CQ) resistance that appeared among different strains of Plasmodium falciparum is considered as the worst catastrophe in the realm of malaria chemotherapy. CQ is still the most favorable drug amon…

8. Article

   Amelioration of Doxorubicin‑Induced Cardiotoxicity by Oral Lyophilized Dunaliella salina Supplement in a Female Wistar Rat Model with Active Estrous Cycle and Surgical Menopause

   Sankaranarayanan Gomathinayagam, Kodiveri Muthukaliannan Gothandam

   pp. S284–S289 · DOI: 10.4103/pm.pm_52_20 · Published 28 August 2020

   Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> L. is a well-known medicinal plant used in traditional medicine for bone healing. Objective: The pres…

9. Article

   DNA Barcoding of Endemic and Endangered Orchids of India: A Molecular Method of Species Identification

   Deepti Srivastava, K. Manjunath

   pp. S290–S299 · DOI: 10.4103/pm.pm_574_19 · Published 28 August 2020

   Background: Orchids are economically important, particularly in horticulture, floristry, pharmaceutical, and fragrance industries. India is a paradise for 1256 orchids, of which 31% (388 species) are endemic. Although In…

10. Article

    Portulaca oleracea Exposed to Polycyclic Aromatic Hydrocarbon Pollution: Mapping Down Nutraceutical and Histochemical Changes

    Roshni Tandey, Kavi Bhushan Singh Chouhan, Vivekananda Mandal

    pp. S300–S307 · DOI: 10.4103/pm.pm_15_20 · Published 28 August 2020

    Aim: Polycyclic aromatic hydrocarbons (PAHs) are extremely carcinogenic environmental pollutants which have now become a global environmental problem. Such pollutants can accumulate in soil and can adversely affect the g…

11. Article

    Neuroprotective Effect of Compounds Isolated from Euonymus alatus on Glutamate‑Induced Oxidative Stress in HT22 Hippocampal Cells

    Youn Sik Jung, Hyeon Woo Lee, Choong Je Ma

    pp. S308–S314 · DOI: 10.4103/pm.pm_450_19 · Published 28 August 2020

    Objectives: In this study, we isolated 10 compounds from E. alatus and confirmed that compounds whether protected neuroral cell (HT22) against glutamate induced toxicity. Materials and Methods: The n‑hexane fraction of E…

12. Article

    Effect of Poly Herbal Formulation “Karisalai chooranam” against Detrimental Effects of Psychological Stress

    S. Mary Princess Sulekha, G. Dayanand Reddy, A. Muthuvel

    pp. S315–S319 · DOI: 10.4103/pm.pm_517_19 · Published 28 August 2020

    Objectives: The objective is to evaluate the efficacy of KSC against detrimental effects of psychological stress. Materials and Methods: Male Wistar albino rats were subjected to restraint stress (6 h/day, 21 days). At t…

13. Article

    Ginkgo biloba Ameliorates Fluoride Toxicity in Rats by Altering Histopathology, Serum Enzymes of Heme Metabolism and Oxidative Stress without Affecting Brain mGluR5 Gene

    Sugavasi Raju, Senthilkumar Sivanesan, Kanchanalatha Gudemalla

    pp. S320–S326 · DOI: 10.4103/pm.pm_534_19 · Published 28 August 2020

    Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant, but other species are less explored. Objective: To evaluate the anti…

14. Article

    Chemical Constituents of Litsea elliptica and their Alpha‑Glucosidase Inhibition with Molecular Docking

    Sathianpong Phoopha, Chatchai Wattanapiromsakul, Thanet Pitakbut, Sukanya Dej‑adisai

    pp. S327–S334 · DOI: 10.4103/pm.pm_18_20 · Published 28 August 2020

    Objectives: The aim was to study on chemical constituents and anti‑diabetic activity through in vitro models of LE. Materials and Methods: Chromatographic and colorimetric enzyme methods with computer molecular docking w…

15. Article

    Chrysin Ameliorates Ovalbumin‑Induced Allergic Response in Allergic Rhinitis: Potential Role of GATA‑3, T‑Box Protein Expressed in T Cells, Nuclear Factor‑Kappa B, and Nuclear Factor Erythroid 2‑Related Factor 2

    Juan Wang, Amit Kandhare, Anwesha Mukherjee‑Kandhare, Subhash L. Bodhankar

    pp. S335–S344 · DOI: 10.4103/pm.pm_461_19 · Published 28 August 2020

    Aim: This study aimed to determine the efficacy and mechanism of action of chrysin against allergic rhinitis (AR) induced by ovalbumin (OVA) in experimental mice. Materials and Methods: Induction of AR was performed in B…

16. Article

    In vitro Anti‑Inflammation, Selective Cytotoxicity, and Inhibition of Induced Nitric Oxide from Lipopolysaccharide‑Stimulated RAW 264.7 Macrophages Activities of Flavonoids from Hermannia geniculata Eckl and Zeyh Roots Extract

    Adeniran Lateef Ariyo, Ohanaka Judith Nkechinyere, Joy Lyndy McGaw, Anofi Omotayo Tom Ashafa

    pp. S345–S349 · DOI: 10.4103/pm.pm_447_19 · Published 28 August 2020

    Aim: Evaluation of in vitro anti‑inflammatory activities of flavonoids of Hermannia geniculata (FHG) roots extract, selective cytotoxicity of Vero and hepatocellular carcinoma (HepG2) cells, as well as its capabilities t…

17. Article

    Comparison of Antioxidant Levels and Anti‑Inflammatory Activities of Kelulut Honey Harvested at Different Month of Intervals and its Chemical Compositions

    Muhammad Aiman Haiqal Ismail, Nurul Sharina Rasyidah Badrulhisham, Vuanghao Lim, Armania Nurdin

    pp. S350–S359 · DOI: 10.4103/pm.pm_451_19 · Published 28 August 2020

    Objectives: This study aims to evaluate the optimum time for harvesting kelulut honey (KH) by determining its antioxidant and anti‑inflammatory activities and chemical composition at different harvesting times. Materials…

18. Article

    Althea rosea Seed Extract Ameliorates 1,2-Dimethylhydrazine Induced Preneoplastic Lesions in Mouse Model of Colon Cancer by Modulating Oxidative Stress and Inflammation

    Arun Narota, Sandeep Kumar, Rhythmjot Kaur, Sachdeep Kaur, Ritu Aggarwal, Navneet Agnihotri

    pp. S360–S370 · DOI: 10.4103/pm.pm_559_19 · Published 28 August 2020

    Background: Phytochemicals with strong antioxidant and anti‑inflammatory properties are known to modulate the process of carcinogenesis. Althea rosea (AR) is an ornamental plant and is an integral part of traditional med…

19. Article

    Potential Antileptospiral Constituents from Phyllanthus amarus

    Chandan S, Umesha S, Shiva Prasad K, Balamurugan V, Chandrashekar S, Santosh Kumar S R, Ramith Ramu, Prithvi S Shirahatti, Asad Syed, Abdallah M. Elgorban

    pp. S371–S378 · DOI: 10.4103/pm.pm_10_20 · Published 28 August 2020

    Objectives: The aim of the study is to investigate antileptospiral activity and isolate the potential antileptospiral constituents of the methanol extract of PA (MPA). Materials and Methods: The primary pharmacological t…

20. Article

    Protective Effect of Carica papaya Leaf Extract against Mercuric Chloride‑Induced Nephrotoxicity in Wistar Rats

    Yuvaraj Maria Francis, J Vijayakumar, Gunapriya Raghunath, S. Vijayalakshmi, Senthilkumar Sivanesan, R. Vijayaraghavan, Ethirajan Sukumar

    pp. S379–S384 · DOI: 10.4103/pm.pm_11_20 · Published 28 August 2020

    Objectives: The aim and objective of this study are to assess the remedial implications of ethanolic ECP leaves on mercuric chloride (HgCl2)‑induced nephrotoxicity in female Wistar rats. The objectives of this study were…

21. Article

    Anti‑inflammatory Activity of Zanthoxylum rhetsa Bark Fractions via Suppression of Nuclear Factor‑kappa B in Lipopolysaccharide‑Stimulated Macrophages

    Ramesh Kumar Santhanam, Katyakyini Muniandy, Sivapragasam Gothai, Khozirah Shaari, Palani Kandasamy Senthilkumar, Palanivel Ganesan, Palanisamy Arulselvan

    pp. S385–S390 · DOI: 10.4103/pm.pm_486_19 · Published 28 August 2020

    Objectives: The objective of this study was to explore and demonstrate the anti‑inflammatory activity of various solvent fractions of Z. rhetsa bark. Materials and Methods: The effect of crude methanolic extract and its …

22. Article

    Cytotoxic Isoprenoids from Xanthium strumarium Linn.

    Hajer S. Alorfi, Amani A. Alshehry, Mohamed A. Ghandourah, Nahed O. Bawakid, Mahmoud A. Elfaky, Aasim M. Ali, Walied M. Alarif

    pp. S391–S395 · DOI: 10.4103/pm.pm_585_19 · Published 28 August 2020

    Objective: Xanthium strumarium is a widespread medicinal plant species; particularly fruits and roots are known for improving memory, voice, and appetite as well as curing of poisonous bites of insects and epilepsy. Mate…

23. Article

    In vitro Antitumor Potential of Methanol Extract of Mimosa pudica in Human Breast Cancer Cell Lines

    Reni John, Bibu John Kariyil, P. T. A. Usha, S. Surya, G. Anu, Preethy John, S. Sujith, Aziz Zarina

    pp. S396–S403 · DOI: 10.4103/pm.pm_527_19 · Published 28 August 2020

    Objectives: The present study was conducted to assess the anticancer activity of methanol extract of whole plant of M. pudica (MMP) in MCF‑7 and MDA‑MB‑231 breast cancer cell lines. Materials and Methods: The antitumor a…

24. Article

    The Potential Aphrodisiac Effect of Ferula drudeana Korovin Extracts and Isolated Sesquiterpene Coumarins in Male Rats

    Mohammed H. Alqarni, Gamal A. Soliman, Mohammad Ayman A. Salkini, Prawez Alam, Hasan S. Yusufoglu, Sura Baykan, Bintug Oztürk, Maged S. Abdel‑Kader

    pp. S404–S409 · DOI: 10.4103/pm.pm_551_19 · Published 28 August 2020

    Objectives: The aim of this study is to confirm the aphrodisiac potential of Ferula drudeana Korovin as listed in the Turkish traditional medicine and to isolate the active metabolites using male rats. Materials and Meth…

25. Article

    Behavioral and Physiological Assessments to Evaluate the Effect of Acacia senegal and Acacia seyal in Albino Mice

    Gadah Albasher, Nahed S. Alharthi, Saad Alkahtani, Nada Aljarba, Nouf Al Sultan, Ahad A. Alsaiari, Omaima Nasir, May Bin-Jumah, Wedad S. Alqahtani

    pp. S410–S417 · DOI: 10.4103/pm.pm_20_20 · Published 28 August 2020

    Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant, but other species are less explored. Objective: To evaluate the anti…

26. Article

    Renoprotective Effects of the Hydroethanolic Extract of Senecio serratuloides against Nw‑Nitro L‑arginine Methyl Ester‑induced Oxidative Stress in Wistar Rats

    Charlotte Mungho Tata, Constance Rufaro Sewani‑Rusike, Opeoluwa Oyehan Oyedeji, Ephraim Tobela Gwebu, Benedicta Ngwenchi Nkeh‑Chungag

    pp. S418–S424 · DOI: 10.4103/pm.pm_375_19 · Published 28 August 2020

    Objectives: This study was aimed at investigating the renoprotective and antioxidant capacity of hydroethanolic extract of Senecio serratuloides (HESS). Materials and Methods: In vitro and ex vivo antioxidant capacity of…

27. Article

    Protective Mechanisms of Piperine against Renal Ischemia– Reperfusion Injury in Rats

    Mohamed Aly Morsy, Mahmoud El‑Daly, Anwaar S. M. Abu Shnaf, Sherif W. Mansour, Ahmed R. N. Ibrahim

    pp. S425–S430 · DOI: 10.4103/pm.pm_586_19 · Published 28 August 2020

    Objectives: We hypothesized that piperine would protect against renal IRI in rats via inhibition of oxidative stress and inflammation. Materials and Methods: Male Sprague Dawley rats were subdivided into four groups; sha…

28. Article

    Protein Expression Patterns in HEK‑Blue™ ‑ Cells Treated with Clinacanthus nutans Extracts

    Shun‑Kai Yang, Teik‑Kee Leo, Chun‑Wai Mai, Swee‑Yee Chin, Dhilia Udie Lamasudin, Swee‑Hua‑Erin Lim, Ngai‑Paing Tan, Kok‑Song Lai

    pp. S431–S434 · DOI: 10.4103/pm.pm_281_19 · Published 28 August 2020

    Objectives: This study aimed to investigate the effect of CN extract on human embryonic kidney cell line (HEK‑Blue™‑4) in a proteomic perspective. Materials and Methods: Comparative proteomic profiling through two‑dimens…

29. Article

    Antitumoral Effect of Lawsonia inermis Extract on Melanoma Tumor‑bearing C57BL/6 Mice

    Wasim Raja, Sonam Pandey

    pp. S435–S442 · DOI: 10.4103/pm.pm_219_19 · Published 20 May 2020

    Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant, but other species are less explored. Objective: To evaluate the anti…