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    Two New Flavonoid Glycosides Isolated from the Fruits of Catalpa ovata

    Liu‑Qiang Zhang2, Hai‑Bing Xue2, Wei‑Liang Zhu3, Yi‑Ming Li2★, Kai‑Xian Chen2,3★★ Corresponding author

    1. 1Department of Traditional Chinese Medicine Chemistry, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, China.
    2. 2Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, China.

    CORRESPONDENCE

    Yi‑Ming Li

    Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, China.

    ymli@shutcm.edu.cn

    Received: 17-03-2020; Revised: 22-04-2020; Accepted: 11-08-2020.

    Volume 16, Issue 72 · pp. 812–816 · PUBLISHED 16 February 2021 · DOI: 10.4103/pm.pm_91_20

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: This communication report presents the results of chemical investigation and antioxidant capacity of the fruits of C. ovata. Materials and Methods: The polar fraction from the fruits of C. ovata was isolated using various chromatographic methods and their structures were identified through nuclear magnetic resonance spectrometry and high‑resolution mass spectrometry, and the data were compared with the reported literature. Total antioxidant activity was analyzed using the total antioxidant capacity assay kit with a rapid ABTS method. Results: Cavonosides A and B (1 and 2), two new flavonoid glycosides, together with 13 known phenols (3–15), were obtained from the fruits of C. ovata. The antioxidant capacity of compounds 4, 7, 10, 13, and 15 was approximately equal to that of Vitamin C at the same concentration. Conclusion: This research work resulted in two new flavonoid glycosides (1 and 2) and 13 known phenols isolated from the fruits of C. ovata; among them, compounds 4, 7–10, and 13 were newly isolated from this genus. According to our results, the antioxidant capacity of compounds 4, 7, 10, 13 and 15 was approximately same as that of Vitamin C at the same concentration. We also discuss the structure–activity relationships of the isolated compounds.

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      Zhang, L., Xue, H., Zhu, W., Li, Y., & Chen, K. (2021). Two New Flavonoid Glycosides Isolated from the Fruits of Catalpa ovata. Pharmacognosy Magazine, 16(72), 812–816. https://doi.org/10.4103/pm.pm_91_20