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    Anti‑Inflammatory and Anti‑Cell Proliferative Effects of Dieckol in the Prevention and Treatment of Colon Cancer Induced by 1,2‑Dimethyl Hydrazine in Experimental Animals

    Baoxiu Yang1★, Ying Li1★, Zhengbo Yang4, Legang Xue5, Minqin Zhang2, Guoliang Chen6, Arunachalam Chinnathambi7, Tahani Awad Alahmadi8, Xu Liu9★★ Corresponding author

    1. 1Department of Chinese Medicine, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei.
    2. 2Department of Emergency, First Teaching Hospital of Tianjin University of TCM, Tianjin.
    3. 3Department of ICU, The First People’s Hospital of Huaihua City, Huaihua, Hunan.
    4. 4Department of Pharmacy, The Affiliated Huai’an Hospital of Xuzhou Medical University and The Second People’s Hospital of Huai’an, Huai’an, Jiangsu.
    5. 5Department of Chinese Medicine, People’s Hospital of Changji Hui Autonomous Prefecture Xinjiang, Changji, Xinjiang, China.
    6. 6Department of Botany and Microbiology, College of Science, King Saud University.
    7. 7Department of Pediatrics, College of Medicine, King Saud University [Medical City], King Khalid University Hospital, Riyadh, Saudi Arabia.
    8. 8Department of Infectious Diseases, Jingmen First People’s Hospital, Jingmen, Hubei, 448000, China.

    CORRESPONDENCE

    Baoxiu Yang

    Department of Chinese Medicine, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei.

    patian516@sina.com

    Received: 05-05-2020; Revised: 11-06-2020; Accepted: 06-08-2020.

    Volume 16, Issue 72 · pp. 851–858 · PUBLISHED 16 February 2021 · DOI: 10.4103/pm.pm_165_20

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: Colon carcinogenesis is a major cause of mortality and morbidity in developing and developed countries, and its etiology is familiar to be a grouping of environmental and nutritional factors, hereditary factors, and deficiency of physical activity. In the present study, we investigated the anti‑cell proliferative and anti‑inflammatory effects of dieckol (DEK) on 1,2‑dimethylhydrazine (DMH)‑treated colon carcinogenesis in investigational rats. Materials and Methods: Colon carcinogenesis was induced with DMH (20 mg/kg body weight) by subcutaneous injection once weekly. We analyzed body weight, tumor incidence, tumor volume, total number of tumors, thiobarbituric acid‑reactive substances (TBARS), antioxidants (glutathione peroxidase, glutathione, catalase, and superoxide dismutase), Phase II (glutathione reductase and glutathione S‑transferase) and Phase I (Cyt‑b5 and CYP450) biotransformation enzymes, and histopathological alterations in the control and investigational rats. Moreover, the inflammatory (interleukin [IL] IL‑1β, cyclooxygenase‑2, tumor necrosis factor‑alpha, IL‑6, and inducible nitric oxide synthase) and cell proliferative (cyclin D1 and PCNA) markers were analyzed by Western blot technique in experimental and control rats. Results: We noted decreased body weight, antioxidants and Phase I and II enzymes, augmented tumor incidence, tumor volume, total number of tumors, TBARS, and irregular histopathological changes in DMH‑induced animals. In addition, the Western blotting analysis of colon tissues showed an upregulation of inflammatory and cell proliferative markers in DMH‑treated rats. Oral supplementation of DEK inhibited the tumor formation, controlled inflammation, cell proliferation, and restoration of biochemical parameters, and it was supported by the histopathological analysis. Conclusion: Findings from the study suggest that DEK demonstrated anticancer, anti‑inflammatory, and anti‑cell proliferative effects against DMH‑treated colon carcinogenesis in rats.

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      Yang, B., Li, Y., Yang, Z., Xue, L., Zhang, M., Chen, G., Chinnathambi, A., Alahmadi, T. A., & Liu, X. (2021). Anti‑Inflammatory and Anti‑Cell Proliferative Effects of Dieckol in the Prevention and Treatment of Colon Cancer Induced by 1,2‑Dimethyl Hydrazine in Experimental Animals. Pharmacognosy Magazine, 16(72), 851–858. https://doi.org/10.4103/pm.pm_165_20