Phcog.Net logo
Submit

BROWSE ALL JOURNALS

    SEE ALL 6 JOURNALS
    Pharmacognosy MagazineNOW IN
    Article

    Effect of Aging and Geographical Variations in the Content of Guggulsterones and Metabolomic Profiling of Oleogum Resins of Commiphora wightii: The Indian Bdellium

    Rajesh Kumar Verma2,3, Mohammad Ibrahim2, Avi Fursule3, Ranjan Mitra3, Jatavallabhula Lakshmi Narayana Sastry4, Sayeed Ahmad2★★ Corresponding author

    1. 1Bioactive Natural Product Laboratory, Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.
    2. 2Dabur Research and Development Centre, Dabur India Limited, Ghaziabad, Uttar Pradesh, India.
    3. 3National Medicinal Plant Board, New Delhi, India.

    CORRESPONDENCE

    Sayeed Ahmad

    Dabur Research and Development Centre, Dabur India Limited, Ghaziabad, Uttar Pradesh, India.

    sahmad_jh@yahoo.co.in

    Received: 16-02-2021; Revised: 27-07-2021; Accepted: 09-09-2021.

    Volume 17, Issue 76 · pp. 774–779 · PUBLISHED 24 January 2022 · DOI: 10.4103/pm.pm_76_21

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: In this paper, the impact of plant aging and geographical variations of guggulsterone (GS) content in oleo‑gum resin collected from different geographical regions of India has been examined. Materials and Methods: The oleo‑gum resin samples of different age groups and geographical regions of India (Kutch, Morena, Jodhpur, Jaipur, and Pakistan border of Kutch) were collected directly from the site and examined to check the concentration of GS‑E and Z by high‑performance liquid chromatography. Comprehensive metabolomic profiling of samples was done through liquid chromatography–mass spectrometry. Results: The data showed that there is no significant variation was found in the concentration of GS‑E and Z with the change in the age of C. wightti plant. The oleo‑gum resin samples of Morena showed a high percentage range of GSs (0.88%–2.17% w/w), whereas Jaipur samples showed a lower percentage of GSs (0.56%–0.89% w/w). From metabolomics profiling, 11 high‑intensity metabolites were identified in samples of all major regions of India. Conclusion: This study indicates that there is no impact of plant aging on the GS contents. The Indian regions such as Morena, Kutch, and Pakistan border near Kutch regions can be used as a potential source for mass multiplication of guggul plants to get the good quality of the oleo‑gum resin.

    KEYWORDS

    Open in new tab

    REFERENCES

    As published

    Showing references and in-text citations exactly as published.

      Cite this article

      SELECT FORMAT

      Verma, R. K., Ibrahim, M., Fursule, A., Mitra, R., Sastry, J. L. N., & Ahmad, S. (2022). Effect of Aging and Geographical Variations in the Content of Guggulsterones and Metabolomic Profiling of Oleogum Resins of Commiphora wightii: The Indian Bdellium. Pharmacognosy Magazine, 17(76), 774–779. https://doi.org/10.4103/pm.pm_76_21