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    Comparison of Esophageal Mucosa Protective Efficacy of Evodiae Fructus and Toosendan Fructus against Duodenogastroesophageal Reflux Esophagitis

    Jin A. Lee1, Mi‑Rae Shin1, Hae‑Jin Park2, Seong‑Soo Roh1★★ Corresponding author

    1. 1Department of Herbology, Korean Medicine of College, Daegu Haany University, Deagu.
    2. 2DHU Bio Convergence Testing Center, Gyeongsangbuk‑do, Republic of Korea.

    CORRESPONDENCE

    Seong‑Soo Roh

    Department of Herbology, Korean Medicine of College, Daegu Haany University, Deagu.

    ddede@dhu.ac.kr

    Received: 21-06-2021; Revised: 23-07-2021; Accepted: 03-11-2021.

    Volume 17, Issue 76 · pp. 811–818 · PUBLISHED 24 January 2022 · DOI: 10.4103/pm.pm_277_21

    View on Pharmacogn. Mag. original site ↗

    ABSTRACT

    Objectives: This work was aimed to assess the impact of Evodiae Fructus and Toosendan Fructus against esophageal mucosal injury with Duodenogastroesophageal Reflux Esophagitis (DGER). Materials and Methods: After inducing DGER through surgery, the group was separated (n = 8) and the drug was administered for 2 weeks: normal rats (Normal), Water-treated DGER (Control), Evodiae Fructus 200 mg/kg‑treated DGER (EF), and Toosendan Fructus 200 mg/kg‑treated DGER (TF). Results: The administration of EF and TF significantly protected the esophageal mucosa. Furthermore, the content of bilirubin, glutamate oxaloacetate transaminase, and glutamate pyruvate transaminase in serum decreased in EF and TF. In addition, those significantly regulated the protein expression of Janus kinase (JAK)/signal transducer and activator of transcription (STAT), AP‑1/MAPK, mtrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP), and tight junction. Conclusion: Taken together, the administration of EF and TF significantly protected the esophageal mucosa of reflux esophagitis, and in particular, the esophageal mucosa protective effect was better in EF. Furthermore, EF and TF inhibited the JAK/STAT and AP‑1/MAPK pathway, and EF significantly modulated the expression of MMP/TIMP. These results show the potential of EF as a material for DGER by alleviating inflammation and improving esophageal function.

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      Lee, J. A., Shin, M., Park, H., & Roh, S. (2022). Comparison of Esophageal Mucosa Protective Efficacy of Evodiae Fructus and Toosendan Fructus against Duodenogastroesophageal Reflux Esophagitis. Pharmacognosy Magazine, 17(76), 811–818. https://doi.org/10.4103/pm.pm_277_21